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Protein

ADP-specific phosphofructokinase

Gene

pfkC

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.UniRule annotation

Catalytic activityi

ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in the pathway glycolysis, which is part of Carbohydrate degradation.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi270MagnesiumUniRule annotation1
Metal bindingi300MagnesiumUniRule annotation1
Active sitei443Proton acceptorUniRule annotation1
Metal bindingi443MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMMAR426368:G1G9C-549-MONOMER
UniPathwayiUPA00109

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-specific phosphofructokinaseUniRule annotation (EC:2.7.1.146UniRule annotation)
Alternative name(s):
ADP-dependent phosphofructokinaseUniRule annotation
Short name:
ADP-PfkUniRule annotation
Gene namesi
Name:pfkCUniRule annotation
Ordered Locus Names:MmarC7_0541Imported
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)Imported
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000002298 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_0541

Structurei

3D structure databases

ProteinModelPortaliA6VGN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili248 – 268Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkC family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG03370 Archaea
COG4809 LUCA
HOGENOMiHOG000254055
KOiK00918
OMAiHLEFASI
OrthoDBiPOG093Z02KX

Family and domain databases

Gene3Di3.40.1190.203 hits
HAMAPiMF_00561 ADP_PFKinase, 1 hit
InterProiView protein in InterPro
IPR007666 ADP_PFK/GK
IPR015990 ADP_PFK/GK_arc
IPR011790 ADP_PFK_arc
IPR029056 Ribokinase-like
PANTHERiPTHR21208 PTHR21208, 1 hit
PfamiView protein in Pfam
PF04587 ADP_PFK_GK, 1 hit
PIRSFiPIRSF015883 ADP-Pfk_glckin, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR02045 P_fruct_ADP, 1 hit
PROSITEiView protein in PROSITE
PS51255 ADPK, 1 hit

Sequencei

Sequence statusi: Complete.

A6VGN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLNQFKNF SNVSIFLAYN VNVDALKYLA DSSDIEKLKE NFSDSDIGLK
60 70 80 90 100
IEEYPRTIEK PIDFVARLIH AMKSGKPAEV PLKNNLEIEP FFNGLNYNEE
110 120 130 140 150
RIGGQVGIIS NLLSILNLKR IIFYSPILAK KQAEMFENNE NLVFPNLIDG
160 170 180 190 200
KLVLKKPIES FKNDELKINR IFEYKEDIEF HLQNEKIITP RSNRFIVASR
210 220 230 240 250
PENLRIEIEK GLKNHLPDIG RLVDCAIISG VQAIKEEYSD GKTAEYYLNR
260 270 280 290 300
VKEDIKLLKK ENKDLKVHFE FASIQNTEMR KKIAESILPE VDCVGMDETE
310 320 330 340 350
IANIIHVLGY EELSEGILKY SRIEDVLKAS KILLERYNLE GMQVHTLYYI
360 370 380 390 400
MYLCKKGGIL SDKSLEKTLE FATILASTKA ALGQISNVGD LKIGLEIPHN
410 420 430 440 450
KHGQLLKELV EKISKEKELE DYRIILVPSR IVENPKSTVG LGDTISAGAF
460
VGYVSELKKL KNK
Length:463
Mass (Da):52,795
Last modified:August 21, 2007 - v1
Checksum:i93D70076E27F12C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA Translation: ABR65609.1
RefSeqiWP_011976940.1, NC_009637.1

Genome annotation databases

EnsemblBacteriaiABR65609; ABR65609; MmarC7_0541
GeneIDi5328645
KEGGimmz:MmarC7_0541

Similar proteinsi

Entry informationi

Entry nameiA6VGN3_METM7
AccessioniPrimary (citable) accession number: A6VGN3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported