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Protein

ADP-specific phosphofructokinase

Gene

pfkC

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.UniRule annotation

Catalytic activityi

ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in the pathway glycolysis, which is part of Carbohydrate degradation.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi270MagnesiumUniRule annotation1
Metal bindingi300MagnesiumUniRule annotation1
Active sitei443Proton acceptorUniRule annotation1
Metal bindingi443MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-specific phosphofructokinaseUniRule annotation (EC:2.7.1.146UniRule annotation)
Alternative name(s):
ADP-dependent phosphofructokinaseUniRule annotation
Gene namesi
Name:pfkCUniRule annotation
Ordered Locus Names:MmarC7_0541Imported
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)Imported
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000002298 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_0541.

Structurei

3D structure databases

ProteinModelPortaliA6VGN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkC family.UniRule annotation
Contains 1 ADPK (ADP-dependent kinase) domain.UniRule annotation

Phylogenomic databases

eggNOGiarCOG03370. Archaea.
COG4809. LUCA.
HOGENOMiHOG000254055.
KOiK00918.
OMAiHLEFASI.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR007666. ADP_PFK/GK.
IPR015990. ADP_PFK/GK_arc.
IPR011790. ADP_PFK_arc.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR21208. PTHR21208. 2 hits.
PfamiPF04587. ADP_PFK_GK. 1 hit.
[Graphical view]
PIRSFiPIRSF015883. ADP-Pfk_glckin. 1 hit.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR02045. P_fruct_ADP. 1 hit.
PROSITEiPS51255. ADPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VGN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLNQFKNF SNVSIFLAYN VNVDALKYLA DSSDIEKLKE NFSDSDIGLK
60 70 80 90 100
IEEYPRTIEK PIDFVARLIH AMKSGKPAEV PLKNNLEIEP FFNGLNYNEE
110 120 130 140 150
RIGGQVGIIS NLLSILNLKR IIFYSPILAK KQAEMFENNE NLVFPNLIDG
160 170 180 190 200
KLVLKKPIES FKNDELKINR IFEYKEDIEF HLQNEKIITP RSNRFIVASR
210 220 230 240 250
PENLRIEIEK GLKNHLPDIG RLVDCAIISG VQAIKEEYSD GKTAEYYLNR
260 270 280 290 300
VKEDIKLLKK ENKDLKVHFE FASIQNTEMR KKIAESILPE VDCVGMDETE
310 320 330 340 350
IANIIHVLGY EELSEGILKY SRIEDVLKAS KILLERYNLE GMQVHTLYYI
360 370 380 390 400
MYLCKKGGIL SDKSLEKTLE FATILASTKA ALGQISNVGD LKIGLEIPHN
410 420 430 440 450
KHGQLLKELV EKISKEKELE DYRIILVPSR IVENPKSTVG LGDTISAGAF
460
VGYVSELKKL KNK
Length:463
Mass (Da):52,795
Last modified:August 21, 2007 - v1
Checksum:i93D70076E27F12C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR65609.1.
RefSeqiWP_011976940.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR65609; ABR65609; MmarC7_0541.
GeneIDi5328645.
KEGGimmz:MmarC7_0541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR65609.1.
RefSeqiWP_011976940.1. NC_009637.1.

3D structure databases

ProteinModelPortaliA6VGN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426368.MmarC7_0541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR65609; ABR65609; MmarC7_0541.
GeneIDi5328645.
KEGGimmz:MmarC7_0541.

Phylogenomic databases

eggNOGiarCOG03370. Archaea.
COG4809. LUCA.
HOGENOMiHOG000254055.
KOiK00918.
OMAiHLEFASI.

Enzyme and pathway databases

UniPathwayiUPA00109.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR007666. ADP_PFK/GK.
IPR015990. ADP_PFK/GK_arc.
IPR011790. ADP_PFK_arc.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR21208. PTHR21208. 2 hits.
PfamiPF04587. ADP_PFK_GK. 1 hit.
[Graphical view]
PIRSFiPIRSF015883. ADP-Pfk_glckin. 1 hit.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR02045. P_fruct_ADP. 1 hit.
PROSITEiPS51255. ADPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6VGN3_METM7
AccessioniPrimary (citable) accession number: A6VGN3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.