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A6VGE5 (AROA_METM7) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:MmarC7_0452
OrganismMethanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]
Taxonomic identifier426368 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_0000325405

Sequences

Sequence LengthMass (Da)Tools
A6VGE5 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 231F60A41171BA9D

FASTA42946,761
        10         20         30         40         50         60 
MLVVKKTPKI KGILSAPPSK SYTHRAVICA SLANGVSNLK NPLNGADCLS SAHACEMFGA 

        70         80         90        100        110        120 
EIDLNDEKWV VRGSEFKTPD NIVDIGNSGT TLRILTGISS QISDGYTVLT GDDSIRKRPM 

       130        140        150        160        170        180 
QPLLDALKQL GLNCFSTKNN GTAPIVVKSG KISNNVVEIR GDMSSQFITS LMMTLPFSEN 

       190        200        210        220        230        240 
DSEIILTTPI KSEPYLNITI DVLDKFGVKI DKIEEKNKVG YKIKGNQKYL PCDYTIEGDY 

       250        260        270        280        290        300 
SSASYLVAAG VLLNSDIVIK NVFKDSKQGD REIIEIVKKM GANVEINEDN VQIMGPYKLK 

       310        320        330        340        350        360 
GIEIDVTDIP DLVPTIAVLG CFAEGKTVVY NGEHVRLKEC DRLAACTTEL SKMGAEIEEK 

       370        380        390        400        410        420 
KDGLIITGVH KLNGAKLKTY HDHRLVMAFT IAGMMADGET VIEGEDSVKI SFPDFVDKMK 


SIGSNIEVI

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References

[1]"Complete sequence of Methanococcus maripaludis C7."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C7 / ATCC BAA-1331.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000745 Genomic DNA. Translation: ABR65521.1.
RefSeqYP_001329672.1. NC_009637.1.

3D structure databases

ProteinModelPortalA6VGE5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6VGE5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5329275.
GenomeReviewsGene locus MmarC7_0452 in contig CP000745_GR.
KEGGmmz:MmarC7_0452.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG05032.
HOGENOMHBG646626.
OMARLRIKEC.
ProtClustDBPRK02427.

Enzyme and pathway databases

BioCycMMAR426368:MMARC7_0452-MONOMER.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_METM7
AccessionPrimary (citable) accession number: A6VGE5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 21, 2007
Last modified: November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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