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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. Sirohydrochlorin cobaltochelatase (cbiX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) (cbiT)
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR426368:G1G9C-455-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:MmarC7_0450
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000002298 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000468651 – 366Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST366

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_0450

Structurei

3D structure databases

ProteinModelPortaliA6VGE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04383 Archaea
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG093Z05FA

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

A6VGE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIDFRLEK TFGYTTGACA AAGAYSALYF LKNNERLNFV EIVNLKEDSL
60 70 80 90 100
IIPIKNIEKQ GDTAISTVEK FSGEDIDITN GMDIEIEVTL NLDNNSSESS
110 120 130 140 150
NVDIIGGIGV GIITKSGLQV TLGKPAINPK PREMIETNLK SLLTDNECVT
160 170 180 190 200
VKISVPNGDE IAKKTLNPKL GIIGGISILG TTGIVRPMSN DAYKESLAPQ
210 220 230 240 250
IDVALANNFE NLIFVPGNIG TKHAKILLHA EEDQIIEVSN FWDYMLNKAK
260 270 280 290 300
EKGVKDITVF GHAGKIVKLA GGIFDTHSKV ADARNEILCA YTSLVTQDVE
310 320 330 340 350
ILQKILQSNT TEDIVEILTE KGILKEVFDN VSKRVVERLS SRWDGINFSC
360
IIINMKGNML GKYDQG
Length:366
Mass (Da):39,981
Last modified:August 21, 2007 - v1
Checksum:i17C28B5653A29475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA Translation: ABR65519.1
RefSeqiWP_011976851.1, NC_009637.1

Genome annotation databases

EnsemblBacteriaiABR65519; ABR65519; MmarC7_0450
GeneIDi5328998
KEGGimmz:MmarC7_0450

Similar proteinsi

Entry informationi

Entry nameiCBID_METM7
AccessioniPrimary (citable) accession number: A6VGE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health