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Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible aldol cleavage of L-fuculose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.By similarity

Catalytic activityi

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681ZincBy similarity
Metal bindingi87 – 871ZincBy similarity
Metal bindingi89 – 891ZincBy similarity
Metal bindingi147 – 1471ZincBy similarity

GO - Molecular functioni

  1. L-fuculose-phosphate aldolase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fucose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-436-MONOMER.
UniPathwayiUPA00071.
UPA00563; UER00626.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculose phosphate aldolase (EC:4.1.2.17)
Alternative name(s):
L-fuculose-1-phosphate aldolase
Gene namesi
Name:fucA
Ordered Locus Names:MmarC7_0434
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000002298: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180L-fuculose phosphate aldolasePRO_0000342596Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi426368.MmarC7_0434.

Structurei

3D structure databases

ProteinModelPortaliA6VGC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0235.
HOGENOMiHOG000218182.
KOiK01628.
OMAiPVVWESS.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR001303. Aldolase_II/adducin_N.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.

Sequencei

Sequence statusi: Complete.

A6VGC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLINFIKIC HLLYDRKYVV GSGGNVSIRD GNHIYITPTG SILGFLNEED
60 70 80 90 100
VCIVDLNGNI IKGKPTSELN MHLKIYQNKD CVNAIVHTHS MYCTAFSALD
110 120 130 140 150
KKLELFTPEA EIVVKKIAYV DYSPCGSLEL AENVSSCVED SIILKNHGIV
160 170 180
TVGKDITEAY VKTEVLEEIA QLNYIINNLK
Length:180
Mass (Da):20,039
Last modified:August 21, 2007 - v1
Checksum:iD63FD14CF12562E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR65503.1.
RefSeqiWP_011976836.1. NC_009637.1.
YP_001329654.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR65503; ABR65503; MmarC7_0434.
GeneIDi5328172.
KEGGimmz:MmarC7_0434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR65503.1.
RefSeqiWP_011976836.1. NC_009637.1.
YP_001329654.1. NC_009637.1.

3D structure databases

ProteinModelPortaliA6VGC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426368.MmarC7_0434.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR65503; ABR65503; MmarC7_0434.
GeneIDi5328172.
KEGGimmz:MmarC7_0434.

Phylogenomic databases

eggNOGiCOG0235.
HOGENOMiHOG000218182.
KOiK01628.
OMAiPVVWESS.

Enzyme and pathway databases

UniPathwayiUPA00071.
UPA00563; UER00626.
BioCyciMMAR426368:GHHL-436-MONOMER.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR001303. Aldolase_II/adducin_N.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C7 / ATCC BAA-1331.

Entry informationi

Entry nameiFUCA_METM7
AccessioniPrimary (citable) accession number: A6VGC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 21, 2007
Last modified: February 4, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.