A6VFW2 (SYR_METM7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	MmarC7_0268

Organism

Methanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]

Taxonomic identifier

426368 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 566	566	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000018063
Regions
	Motif	121 – 131	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	A6VFW2 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: AB25D6AC52DDB644	FASTA	566	64,348
	10 20 30 40 50 60 MDVENLIITT LKDKVEELTG NEMDIRLDEP PAINMGDYST NISFRLAKDL KKAPKVIAED 70 80 90 100 110 120 IANSLNISGI EKIEAVNGYI NFFMNYSDFS KETVSKIIDE KENFGKLEKR HEKVILEHTS 130 140 150 160 170 180 ANPNGPFHIG HGRNMVIGDS LKRILVASGY DVETQYYVND MGRQEAIVVF GNEKFELDKS 190 200 210 220 230 240 KKADHAIGEV YVETNKLLAE NEELEQEILN LMKNYEEACE AGIENELTEK FKNAVDYSLG 250 260 270 280 290 300 GFKETLSTLN IYHDKFVWES EFVKSGMVRE VIKRLMDTGK VVEDEVFRLD LSDYGLEKKL 310 320 330 340 350 360 VLARLNGTSL YSTRDIAYHI NKMENCDFAV NLLGADHKLT AVMVNKTLAL LGYNEAEVVF 370 380 390 400 410 420 YEFISLPEGS MSTRRGRFIS MDELFEEAKS RAAEEVRKRG VAESEEEIEE IAKKIAVGAV 430 440 450 460 470 480 RYNIVRIAPE KPMVFRWDEA LDFEKVGCPV IQYAHARCSR ILENVEIISN DNLFAYEMNE 490 500 510 520 530 540 NEKTIVKLLS KLPKIVEKAA EVRKPQIVAN YVLDVAQGFN KFYANCPVLK EENQIIKNSR 550 560 IAIVNNTKMV LENTLDLLGI EMPGKM

References

[1]

"Complete sequence of Methanococcus maripaludis C7." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C7 / ATCC BAA-1331.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000745 Genomic DNA. Translation: ABR65338.1.
RefSeq	YP_001329489.1. NC_009637.1.
3D structure databases
ProteinModelPortal	A6VFW2.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VFW2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5329407.
GenomeReviews	Gene locus MmarC7_0268 in contig CP000745_GR.
KEGG	mmz:MmarC7_0268.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04487.
HOGENOM	HBG695395.
OMA	NPNGPLH.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	MMAR426368:MMARC7_0268-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_METM7

Accession

Primary (citable) accession number: A6VFW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program