Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6VFW2 (SYR_METM7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:MmarC7_0268
OrganismMethanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]
Taxonomic identifier426368 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018063

Regions

Motif121 – 13111"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A6VFW2 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: AB25D6AC52DDB644

FASTA56664,348
        10         20         30         40         50         60 
MDVENLIITT LKDKVEELTG NEMDIRLDEP PAINMGDYST NISFRLAKDL KKAPKVIAED 

        70         80         90        100        110        120 
IANSLNISGI EKIEAVNGYI NFFMNYSDFS KETVSKIIDE KENFGKLEKR HEKVILEHTS 

       130        140        150        160        170        180 
ANPNGPFHIG HGRNMVIGDS LKRILVASGY DVETQYYVND MGRQEAIVVF GNEKFELDKS 

       190        200        210        220        230        240 
KKADHAIGEV YVETNKLLAE NEELEQEILN LMKNYEEACE AGIENELTEK FKNAVDYSLG 

       250        260        270        280        290        300 
GFKETLSTLN IYHDKFVWES EFVKSGMVRE VIKRLMDTGK VVEDEVFRLD LSDYGLEKKL 

       310        320        330        340        350        360 
VLARLNGTSL YSTRDIAYHI NKMENCDFAV NLLGADHKLT AVMVNKTLAL LGYNEAEVVF 

       370        380        390        400        410        420 
YEFISLPEGS MSTRRGRFIS MDELFEEAKS RAAEEVRKRG VAESEEEIEE IAKKIAVGAV 

       430        440        450        460        470        480 
RYNIVRIAPE KPMVFRWDEA LDFEKVGCPV IQYAHARCSR ILENVEIISN DNLFAYEMNE 

       490        500        510        520        530        540 
NEKTIVKLLS KLPKIVEKAA EVRKPQIVAN YVLDVAQGFN KFYANCPVLK EENQIIKNSR 

       550        560 
IAIVNNTKMV LENTLDLLGI EMPGKM 

« Hide

References

[1]"Complete sequence of Methanococcus maripaludis C7."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C7 / ATCC BAA-1331.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000745 Genomic DNA. Translation: ABR65338.1.
RefSeqYP_001329489.1. NC_009637.1.

3D structure databases

ProteinModelPortalA6VFW2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING426368.MmarC7_0268.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR65338; ABR65338; MmarC7_0268.
GeneID5329407.
KEGGmmz:MmarC7_0268.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMANPNGPLH.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycMMAR426368:GHHL-269-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_METM7
AccessionPrimary (citable) accession number: A6VFW2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries