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A6VFU7

- SYE_METM7

UniProt

A6VFU7 - SYE_METM7

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Protein
Glutamate--tRNA ligase
Gene
gltX, MmarC7_0253
Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:MmarC7_0253
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000002298: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Glutamate--tRNA ligaseUniRule annotation
PRO_0000331006Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_0253.

Structurei

3D structure databases

ProteinModelPortaliA6VFU7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi100 – 11011"HIGH" regionUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiYLGWDDP.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VFU7-1 [UniParc]FASTAAdd to Basket

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MKDTVMAYLL ENSIKFKGKP NPKAAMGKIL GENPDLRSNV KELNEVISEV    50
VKEIESMSLE EQQAKLDELA PEGLGQKTER KRKEIELKNV KGNVVMRFAP 100
NPSGPLHIGH ARASVLNDFF TKKYNGKLVL RLEDTDAKRV LPEAYEMIQE 150
DLKWLGVKVD EVIVQSERLE IYYEYGRKLI EMGHAYVCDC DAEEFRNLRE 200
QGIPCKCRDT TPEENIALWE KMLAGELENV AVRLKTDIVH KNPSIRDFPI 250
FRIERTPHPK NGTKYHVYPL MNLSVTVDDH LLGMTHVLRG KDHIVNTEKQ 300
EYIYNYFGWE IPEYVHYGIL KIEGPVLSTS KMHAGILSGE YSGWDDARLG 350
TLRALRKRGI RPEALYKLMV EIGIKQADVR FAWENLYAAN KDIIDKDARR 400
FFFVESPKKL VISGAESKKI DLRMHPDRNE LGNRELLFDG EIYVSDDLEV 450
GTMYRLMELF NIVIEKIEND VIYAKYDSDD LAVAKSNKAS IIHWIPVKDS 500
IPVTVIDENA EKIEGFAEKD FAVVNEDDFV QFERFGFVRV DEKEDNGYTC 550
YLTHK 555
Length:555
Mass (Da):63,931
Last modified:August 21, 2007 - v1
Checksum:iB3ADF7EE8E643159
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000745 Genomic DNA. Translation: ABR65323.1.
RefSeqiWP_011976660.1. NC_009637.1.
YP_001329474.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR65323; ABR65323; MmarC7_0253.
GeneIDi5328347.
KEGGimmz:MmarC7_0253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000745 Genomic DNA. Translation: ABR65323.1 .
RefSeqi WP_011976660.1. NC_009637.1.
YP_001329474.1. NC_009637.1.

3D structure databases

ProteinModelPortali A6VFU7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426368.MmarC7_0253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR65323 ; ABR65323 ; MmarC7_0253 .
GeneIDi 5328347.
KEGGi mmz:MmarC7_0253.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi YLGWDDP.

Enzyme and pathway databases

BioCyci MMAR426368:GHHL-254-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
2.40.240.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C7 / ATCC BAA-1331.

Entry informationi

Entry nameiSYE_METM7
AccessioniPrimary (citable) accession number: A6VFU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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