Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A6VFK8

- DAPF_METM7

UniProt

A6VFK8 - DAPF_METM7

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Binding sitei44 – 441SubstrateUniRule annotation
Binding sitei62 – 621SubstrateUniRule annotation
Active sitei71 – 711Proton donor/acceptorUniRule annotation
Binding sitei160 – 1601SubstrateUniRule annotation
Sitei162 – 1621Important for catalytic activityUniRule annotation
Binding sitei193 – 1931SubstrateUniRule annotation
Sitei211 – 2111Important for catalytic activityUniRule annotation
Active sitei220 – 2201Proton donor/acceptorUniRule annotation

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-165-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
Short name:
DAP epimeraseUniRule annotation
Gene namesi
Name:dapFUniRule annotation
Ordered Locus Names:MmarC7_0164
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000002298: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Diaminopimelate epimerasePRO_1000124423Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 220

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_0164.

Structurei

3D structure databases

ProteinModelPortaliA6VFK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 92Substrate bindingUniRule annotation
Regioni71 – 733Substrate bindingUniRule annotation
Regioni211 – 2122Substrate bindingUniRule annotation
Regioni221 – 2222Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the diaminopimelate epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiLIVEPPY.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VFK8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFTKMHGLG NDYIYVDATS QKIENPNEIS RFVSDRHFGI GSDGLVLILP
60 70 80 90 100
SEIADFKMRM FNSDGSEAEM CGNAIRCVGK FVYDKKMTDK STITIETLAG
110 120 130 140 150
IKVLEMTVEN DKVVLVKVDM GEPILKAETI PVLSEKHPVI DEEITAKDYC
160 170 180 190 200
YNFTCVSMGN PHAITYIENV SEFPLEKIGP LFEFHEKFPR KTNVEFVELI
210 220 230 240 250
DDSTIKMRVW ERGAGETLAC GTGACAVLVA SVLKGYVGRK ATVKLLGGDL
260 270
TIEWNESDNH IYMTGPATTV FEGEIDI
Length:277
Mass (Da):30,798
Last modified:August 21, 2007 - v1
Checksum:i5398BFB706F37D10
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000745 Genomic DNA. Translation: ABR65234.1.
RefSeqiWP_011976571.1. NC_009637.1.
YP_001329385.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR65234; ABR65234; MmarC7_0164.
GeneIDi5328025.
KEGGimmz:MmarC7_0164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000745 Genomic DNA. Translation: ABR65234.1 .
RefSeqi WP_011976571.1. NC_009637.1.
YP_001329385.1. NC_009637.1.

3D structure databases

ProteinModelPortali A6VFK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426368.MmarC7_0164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR65234 ; ABR65234 ; MmarC7_0164 .
GeneIDi 5328025.
KEGGi mmz:MmarC7_0164.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi LIVEPPY.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci MMAR426368:GHHL-165-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C7 / ATCC BAA-1331.

Entry informationi

Entry nameiDAPF_METM7
AccessioniPrimary (citable) accession number: A6VFK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3