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Protein

Ribonuclease Z

Gene

rnz

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc 1; catalyticUniRule annotation1
Metal bindingi62Zinc 1; catalyticUniRule annotation1
Active sitei64Proton acceptorUniRule annotation1
Metal bindingi64Zinc 2; catalyticUniRule annotation1
Metal bindingi65Zinc 2; catalyticUniRule annotation1
Metal bindingi140Zinc 1; catalyticUniRule annotation1
Metal bindingi209Zinc 1; catalyticUniRule annotation1
Metal bindingi209Zinc 2; catalyticUniRule annotation1
Metal bindingi269Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:MmarC7_0153
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000002298 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000702991 – 310Ribonuclease ZAdd BLAST310

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi426368.MmarC7_0153.

Structurei

3D structure databases

ProteinModelPortaliA6VFJ7.
SMRiA6VFJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiGTQRQMM.
OrthoDBiPOG093Z04VY.

Family and domain databases

CDDicd07717. RNaseZ_ZiPD-like_MBL-fold. 1 hit.
Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiView protein in InterPro
IPR001279. Metallo-B-lactamas.
IPR036866. Metallo-hydrolase/OxRdtase.
IPR013471. RNase_Z/BN.
PfamiView protein in Pfam
PF12706. Lactamase_B_2. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

A6VFJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTFLGTGA AIPTKYRAHP SISLKFDGEI FLFDCGENTQ RQIIFTDVSP
60 70 80 90 100
MKINNIFISH LHGDHILGIP GLMQSIAFQG RTKPLNIYGP KETAKMIENI
110 120 130 140 150
LNVGYHSIDY PINVYEISAK SPEKIISSDN YEVFSFPVVH SVPALAYVFK
160 170 180 190 200
QVKKPRMDLE KVNKLGIEIG PDLKRLKDGF NIELNGKIIT PDDVTVPPKK
210 220 230 240 250
GICVGYSGDT IPLNEFAEFL KELKCTTLIH EATFDKSMDK NAKETLHSTV
260 270 280 290 300
SDALNIAKLS GVNTVILTHI SARYDEISAY EKDIVEFKAE HPDLHILIAE
310
DLMEYSLKGK
Length:310
Mass (Da):34,653
Last modified:August 21, 2007 - v1
Checksum:iA6EC20EC6A436A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR65223.1.
RefSeqiWP_011976560.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR65223; ABR65223; MmarC7_0153.
GeneIDi5329588.
KEGGimmz:MmarC7_0153.

Similar proteinsi

Entry informationi

Entry nameiRNZ_METM7
AccessioniPrimary (citable) accession number: A6VFJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: October 25, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families