Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease Z

Gene

rnz

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Zinc 1; catalyticUniRule annotation
Metal bindingi62 – 621Zinc 1; catalyticUniRule annotation
Active sitei64 – 641Proton acceptorUniRule annotation
Metal bindingi64 – 641Zinc 2; catalyticUniRule annotation
Metal bindingi65 – 651Zinc 2; catalyticUniRule annotation
Metal bindingi140 – 1401Zinc 1; catalyticUniRule annotation
Metal bindingi209 – 2091Zinc 1; catalyticUniRule annotation
Metal bindingi209 – 2091Zinc 2; catalyticUniRule annotation
Metal bindingi269 – 2691Zinc 2; catalyticUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-154-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:MmarC7_0153
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000002298 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Ribonuclease ZPRO_1000070299Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi426368.MmarC7_0153.

Structurei

3D structure databases

ProteinModelPortaliA6VFJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

A6VFJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTFLGTGA AIPTKYRAHP SISLKFDGEI FLFDCGENTQ RQIIFTDVSP
60 70 80 90 100
MKINNIFISH LHGDHILGIP GLMQSIAFQG RTKPLNIYGP KETAKMIENI
110 120 130 140 150
LNVGYHSIDY PINVYEISAK SPEKIISSDN YEVFSFPVVH SVPALAYVFK
160 170 180 190 200
QVKKPRMDLE KVNKLGIEIG PDLKRLKDGF NIELNGKIIT PDDVTVPPKK
210 220 230 240 250
GICVGYSGDT IPLNEFAEFL KELKCTTLIH EATFDKSMDK NAKETLHSTV
260 270 280 290 300
SDALNIAKLS GVNTVILTHI SARYDEISAY EKDIVEFKAE HPDLHILIAE
310
DLMEYSLKGK
Length:310
Mass (Da):34,653
Last modified:August 21, 2007 - v1
Checksum:iA6EC20EC6A436A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR65223.1.
RefSeqiWP_011976560.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR65223; ABR65223; MmarC7_0153.
GeneIDi5329588.
KEGGimmz:MmarC7_0153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR65223.1.
RefSeqiWP_011976560.1. NC_009637.1.

3D structure databases

ProteinModelPortaliA6VFJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426368.MmarC7_0153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR65223; ABR65223; MmarC7_0153.
GeneIDi5329588.
KEGGimmz:MmarC7_0153.

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-154-MONOMER.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNZ_METM7
AccessioniPrimary (citable) accession number: A6VFJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: December 9, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.