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A6VF17

- GCH4_PSEA7

UniProt

A6VF17 - GCH4_PSEA7

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPAER381754:GHMY-6339-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PSPA7_6341
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001582: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP cyclohydrolase FolE2PRO_0000316531Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381754.PSPA7_6341.

Structurei

3D structure databases

ProteinModelPortaliA6VF17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VF17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNALTLPDIA RQTTLSTLPL DWVGMQGIAL PVQVAGQTVA AEADAGVSLD
60 70 80 90 100
DPQARGIHMS RLYLALAGLE DGELDLPRLR GVLQRFLDSH ADLSRRAYLR
110 120 130 140 150
LRLAPLLRRP ALVSPLSGWK RYPLVLDTRL ENGTFQADLH LELTYSSTCP
160 170 180 190 200
CSAALARQLI QERFAQDFAG QQPDHATILA WLGSSDGIVA TPHSQRSSAQ
210 220 230 240 250
LRIGLAEDCA GLPLEELADL GECALGTAVQ TAVKRADEQA FALANGQNLM
260 270 280 290
FCEDAVRRLH RALRGYPQAR EFSVRVVHAE SLHAHDAVAE SHWQRGAA
Length:298
Mass (Da):32,446
Last modified:August 21, 2007 - v1
Checksum:i8E06CD6D3A8FC9DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR81478.1.
RefSeqiYP_001351652.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR81478; ABR81478; PSPA7_6341.
GeneIDi5357077.
KEGGipap:PSPA7_6341.
PATRICi19834137. VBIPseAer80442_6036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR81478.1 .
RefSeqi YP_001351652.1. NC_009656.1.

3D structure databases

ProteinModelPortali A6VF17.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381754.PSPA7_6341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR81478 ; ABR81478 ; PSPA7_6341 .
GeneIDi 5357077.
KEGGi pap:PSPA7_6341.
PATRICi 19834137. VBIPseAer80442_6036.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PAER381754:GHMY-6339-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Dodson R.J., Harkins D., Paulsen I.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA7.

Entry informationi

Entry nameiGCH4_PSEA7
AccessioniPrimary (citable) accession number: A6VF17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3