Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciPAER381754:GHMY-6155-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:PSPA7_6157
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001582: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Oxygen-dependent choline dehydrogenasePRO_1000046566Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381754.PSPA7_6157.

Structurei

3D structure databases

ProteinModelPortaliA6VEI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiNQFEACA.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VEI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQEFDYIII GAGSAGNVLA TRLTEDADVS VLLLEAGGPD YRFDFRTQMP
60 70 80 90 100
AALAFPLQGR RYNWAYETDP EPYMNNRRME CGRGKGLGGS SLINGMCYIR
110 120 130 140 150
GNALDFDGWA KEPGLEDWSY LDCLPYFRKA ETRDIGPNDY HGGDGPVSVT
160 170 180 190 200
TPKAGNNPLF HAMVEAGVQA GYPRTEDLNG YQQEGFGPMD RTVTPEGRRA
210 220 230 240 250
ATGRGYLDQA RGRPNLTIVT HALSDRILFS GKRAIGVSYL VGNGDNPVTA
260 270 280 290 300
HARREVLVCS GAIASPQLLQ RSGVGPAALL RDLDIPVVHD LPGVGANLQD
310 320 330 340 350
HLELYLQYAC KQPVSIYPAT KWWNQPAIGA QWLFLGKGLG ASNQFEAGGF
360 370 380 390 400
IRTREAFEWP NIQFHFLPVA INYNGSKGVQ EHGFQAHMGS MRSPSRGRIH
410 420 430 440 450
LKSRDPRQHP SILFNYMSHE QDWQEFRDGI RLTREIMNQP ALDPYRGREL
460 470 480 490 500
SPGVNVQSDA ELDEFIRNHA ETAFHPSCSC KMGSDDMAVV DGQGRVHGME
510 520 530 540 550
GLRVVDASIM PLIITGNLNA TTIMMAEKIA DRIRGRQPLP RSTAKYYVAG
560
DAPVRGKPVR A
Length:561
Mass (Da):61,892
Last modified:August 21, 2007 - v1
Checksum:i5E9E63FD6F955C5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR85536.1.
RefSeqiWP_012077968.1. NC_009656.1.
YP_001351468.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR85536; ABR85536; PSPA7_6157.
GeneIDi5357019.
KEGGipap:PSPA7_6157.
PATRICi19833779. VBIPseAer80442_5857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR85536.1.
RefSeqiWP_012077968.1. NC_009656.1.
YP_001351468.1. NC_009656.1.

3D structure databases

ProteinModelPortaliA6VEI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381754.PSPA7_6157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR85536; ABR85536; PSPA7_6157.
GeneIDi5357019.
KEGGipap:PSPA7_6157.
PATRICi19833779. VBIPseAer80442_5857.

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiNQFEACA.
OrthoDBiEOG67HJQP.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.
BioCyciPAER381754:GHMY-6155-MONOMER.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Dodson R.J., Harkins D., Paulsen I.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA7.

Entry informationi

Entry nameiBETA_PSEA7
AccessioniPrimary (citable) accession number: A6VEI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: February 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.