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A6VCM8 (LLDD_PSEA7) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase [cytochrome]
EC=1.1.2.3
Gene names
Name:lldD
Ordered Locus Names:PSPA7_5491
OrganismPseudomonas aeruginosa (strain PA7) [Complete proteome] [HAMAP]
Taxonomic identifier381754 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559

Cofactor

FMN By similarity. HAMAP MF_01559

Subunit structure

Homotetramer By similarity. HAMAP MF_01559

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Ontologies

Keywords
   LigandFMN
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlactate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381L-lactate dehydrogenase [cytochrome] HAMAP MF_01559
PRO_1000068988

Regions

Domain1 – 380380FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
A6VCM8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: AB7EB6CC1AA39CE9

FASTA38141,123
        10         20         30         40         50         60 
MIISASTDYR AAAQRKLPPF LFHYIDGGAY AEYTLRRNVE DLSAIALRQR VLKNMSELSL 

        70         80         90        100        110        120 
ETRLFDETLA MPVALAPVGL TGMYARRGEV QAARAAAAKG VPFTLSTVSV CPIEEVAPAI 

       130        140        150        160        170        180 
DRPMWFQLYV LKDRGFMRNA LERAKAAGVT TLVFTVDMPV PGARYRDAHS GMSGPYAAPR 

       190        200        210        220        230        240 
RILQAMTHPA WAWDVGLLGK PHDLGNISTY RGNPTGLEDY IGWLGANFDP SISWKDLEWI 

       250        260        270        280        290        300 
REFWNGPMVI KGILDPEDAK DAVKFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGE 

       310        320        330        340        350        360 
LAILADSGIR TGLDVVRMIA LGADSVLLGR AFVYALAAAG EAGVRNLLEL IEKEMRVAMV 

       370        380 
LTGAKSIGEI SADSLVRELG A

« Hide

References

[1]Dodson R.J., Harkins D., Paulsen I.T.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PA7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000744 Genomic DNA. Translation: ABR83637.1.
RefSeqYP_001350813.1. NC_009656.1.

3D structure databases

ProteinModelPortalA6VCM8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6VCM8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5354272.
GenomeReviewsGene locus PSPA7_5491 in contig CP000744_GR.
KEGGpap:PSPA7_5491.
PATRIC19832477. VBIPseAer80442_5217.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1304.
HOGENOMHBG517781.
OMAIGWLTEN.
PhylomeDBA6VCM8.
ProtClustDBPRK11197.

Family and domain databases

HAMAPMF_01559. L-lact_dehydr.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_cyt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00101.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLLDD_PSEA7
AccessionPrimary (citable) accession number: A6VCM8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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