A6VCI9 (A6VCI9_PSEA7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 2 HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase 2 HAMAP MF_01123
Acyl-activating enzyme 2 HAMAP MF_01123

Gene names

Name:	acsA1 EMBL ABR81161.1
Synonyms:	acsA2 HAMAP MF_01123
Ordered Locus Names:	PSPA7_5450

Organism

Pseudomonas aeruginosa (strain PA7) [Complete proteome] [HAMAP]

Taxonomic identifier

381754 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	645 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL ABR81161.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	514	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	606	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	A6VCI9 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: A79859750A162AB0	FASTA	645	71,695
	10 20 30 40 50 60 MFEISVHPVP EAVRQRAYLN DDDYRRLYRQ SVENPEEFWG EQAKAFLDWF KPWHSVHHGD 70 80 90 100 110 120 LRKGQASWFK GGQLNVAYNC IDRHLERRGE QIAIVWEGDN PSESAHITYR KLHHNVCRLA 130 140 150 160 170 180 NVLKSRGVEK GDRVCIYMPM IPEAAYAMLA CARIGAVHSV VFGGFSPDSL RDRILDADCR 190 200 210 220 230 240 TVITADEGVR GGKYIPLKQN VEKALEDCPE VSTVVVVERT QGDIPWVEGR DLWYHEALHA 250 260 270 280 290 300 ASADCPAEAM DAEDPLFILY TSGSTGKPKG VLHTTGGYLL GAAMTHKYVF DYHDGDVYWC 310 320 330 340 350 360 TADVGWVTGH SYIVYGPLAN GATTLMFEGV PNYPDASRFW QVIDKHQVNI FYTAPTAIRA 370 380 390 400 410 420 LMREGDGPVR QTSRSSLRLL GSVGEPINPE AWEWYYQVVG EKRCPIVDTW WQTETGSILI 430 440 450 460 470 480 TPLPGATALK PGSATRPFFG VQPVLLDEKG KEIDGAGSGV LAIKASWPSQ IRSVYGDHQR 490 500 510 520 530 540 MIDTYFKPYP GYYFSGDGAR RDEDGYYWIT GRVDDVINVS GHRIGTAEVE SALVLHDAVA 550 560 570 580 590 600 EAAVVGCPHE VKGQAIYAFV TLMAGSQPDE ALQQELLALV GKEIGSFAKP DHLQWAPSLP 610 620 630 640 KTRSGKIMRR ILRKIACNEL DSLGDTSTLA DPGVVQGLID NRLNR

References

[1]	Dodson R.J., Harkins D., Paulsen I.T. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000744 Genomic DNA. Translation: ABR81161.1.
RefSeq	YP_001350774.1. NC_009656.1.
3D structure databases
ProteinModelPortal	A6VCI9.
SMR	A6VCI9. Positions 7-642.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VCI9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5357784.
GenomeReviews	Gene locus PSPA7_5450 in contig CP000744_GR.
KEGG	pap:PSPA7_5450.
PATRIC	19832395. VBIPseAer80442_5178.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	IARTIWG.
PhylomeDB	A6VCI9.
ProtClustDB	PRK00174.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A6VCI9_PSEA7

Accession

Primary (citable) accession number: A6VCI9

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)