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Protein

Ferrochelatase

Gene

hemH

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi189IronUniRule annotation1
Metal bindingi292IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotation
Ordered Locus Names:PSPA7_5304
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000001582 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000193441 – 340FerrochelataseAdd BLAST340

Structurei

3D structure databases

ProteinModelPortaliA6VC51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000060730.
KOiK01772.
OMAiWEEGSPL.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 2 hits.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.

Sequencei

Sequence statusi: Complete.

A6VC51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENALLLLN LGSPDSTRVE DVRRYLDQFL MDPYVVDLPW PLRRLLVSLI
60 70 80 90 100
LVKRPAESAH AYSSIWWDEG SPLIVLSRRL QEAIKPHWPH GPVELAMRYG
110 120 130 140 150
QPAIEKVLLD LARRGIRRVT LAPLYPQFAD STTTTAEQEV RRVIAAHRLE
160 170 180 190 200
LEVSTLPPFY DQPVYLDALV ESVHPYLQQP HDHLLLSFHG LPERHIRKLV
210 220 230 240 250
KDPAHDLLAE SSRNVSPEAL ALCYRSQCLR TAEAFAERAG LEQGRWSVSF
260 270 280 290 300
QSRLGRAKWI EPYTDAKLDE LVQRGVKRLL VMCPAFVADC IETLEEIGMR
310 320 330 340
GREQFISAGG EDLVLIPCLN DHPAWVGALA DMSGRLARPL
Length:340
Mass (Da):38,551
Last modified:August 21, 2007 - v1
Checksum:i228E2DD1877EBA4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR85109.1.
RefSeqiWP_003149922.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR85109; ABR85109; PSPA7_5304.
KEGGipap:PSPA7_5304.
PATRICi19832145. VBIPseAer80442_5060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR85109.1.
RefSeqiWP_003149922.1. NC_009656.1.

3D structure databases

ProteinModelPortaliA6VC51.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR85109; ABR85109; PSPA7_5304.
KEGGipap:PSPA7_5304.
PATRICi19832145. VBIPseAer80442_5060.

Phylogenomic databases

HOGENOMiHOG000060730.
KOiK01772.
OMAiWEEGSPL.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 2 hits.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEMH_PSEA7
AccessioniPrimary (citable) accession number: A6VC51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.