A6VC08 (RLMG_PSEA7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA large subunit methyltransferase G
EC=2.1.1.174

Alternative name(s):
23S rRNA m2G1835 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RlmG

Gene names

Name:	rlmG
Ordered Locus Names:	PSPA7_5261

Organism

Pseudomonas aeruginosa (strain PA7) [Complete proteome] [HAMAP]

Taxonomic identifier

381754 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the guanosine in position 1835 (m2G1835) of 23S rRNA By similarity. HAMAP MF_01859
Catalytic activity	S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanosine(1835) in 23S rRNA. HAMAP MF_01859
Subcellular location	Cytoplasm Potential HAMAP MF_01859.
Sequence similarities	Belongs to the methyltransferase superfamily. RlmG family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro rRNA (guanine-N2-)-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Ribosomal RNA large subunit methyltransferase G HAMAP MF_01859		PRO_0000366473

Sequences

	Sequence		Length	Mass (Da)
	A6VC08 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: A3963629422A3F0B	FASTA	374	40,466
	10 20 30 40 50 60 MPLFATPFAQ LDLIRQPEQD GEPLQAFDAA DEYLLNHLYE RGVTAQSRIL VLNDAFGALA 70 80 90 100 110 120 ASLAPHVQLT SSGDSHLGFL ALRKNLARNG LDLGSVRFVP ASETAVGPFD HVLVKVPKTL 130 140 150 160 170 180 ALLEEQLIRL HGQLAPGAQV VAAGMVKHLP RAAGDLLERY IGPMHASLAV KKARLLVAEA 190 200 210 220 230 240 AERPAPRSPY PTRYRLEQPP LTLLNHANVF CREGLDIGTR AFLPHLPRSL GALRAADLGC 250 260 270 280 290 300 GNGVLGIAYA LLNPQAELTL VDESYMAVQS ARENWRAALG ERPAAFRADD GLAGQAAGSL 310 320 330 340 350 360 DLVLCNPPFH QQQVVGDFLA WRMFLQARDA LAAGGELWIV GNRHLGYHAK LKRLFRGVEQ 370 VAANPKFVIL KAGK

References

[1]	Dodson R.J., Harkins D., Paulsen I.T. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PA7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000744 Genomic DNA. Translation: ABR81820.1.
RefSeq	YP_001350593.1. NC_009656.1.
3D structure databases
ProteinModelPortal	A6VC08.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VC08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5358549.
GenomeReviews	Gene locus PSPA7_5261 in contig CP000744_GR.
KEGG	pap:PSPA7_5261.
PATRIC	19832061. VBIPseAer80442_5018.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2813.
HOGENOM	HBG321931.
OMA	NRHLGYH.
PhylomeDB	A6VC08.
ProtClustDB	CLSK868782.
Family and domain databases
HAMAP	MF_01859. 23SrRNA_methyltr_G. [Tree]
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR017237. rRNA_m2G-MeTrfase_RsmD. IPR007848. Small_mtfrase. [Graphical view]
KO	K00564.
Pfam	PF05175. MTS. 1 hit. [Graphical view]
PIRSF	PIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RLMG_PSEA7

Accession

Primary (citable) accession number: A6VC08

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program