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A6VAK6 (RNC_PSEA7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribonuclease 3
EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:PSPA7_4749
OrganismPseudomonas aeruginosa (strain PA7) [Complete proteome] [HAMAP]
Taxonomic identifier381754 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Ribonuclease 3 HAMAP-Rule MF_00104
PRO_1000075786

Regions

Domain5 – 127123RNase III
Domain154 – 22471DRBM

Sites

Active site441 Potential
Active site1161 By similarity
Metal binding401Magnesium By similarity
Metal binding1131Magnesium By similarity
Metal binding1161Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
A6VAK6 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 9635BD6EA2043520

FASTA22925,488
        10         20         30         40         50         60 
MSNPLDRLER KLGYTFKDQD LMVLALTHRS YAGRNNERLE FLGDAILNFV IGEALFHHFP 

        70         80         90        100        110        120 
QAREGQLSRL RARLVKGETL ALLARGFEVG DYLRLGSGEL KSGGFRRESI LADAMEALIG 

       130        140        150        160        170        180 
AIYLDTGMDS ARERIIAWLG PQLRELTPVD TNKDPKTRLQ EFLQSRGCDL PRYEVVDIQG 

       190        200        210        220 
EPHCRTFFVD CEVALLSDKT HGHGGSRRIA EQVAAAAALV ALGVENGHD

« Hide

References

[1]Dodson R.J., Harkins D., Paulsen I.T.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PA7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000744 Genomic DNA. Translation: ABR83659.1.
RefSeqYP_001350091.1. NC_009656.1.

3D structure databases

ProteinModelPortalA6VAK6.
ModBaseSearch...

Protein-protein interaction databases

STRING381754.PSPA7_4749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR83659; ABR83659; PSPA7_4749.
GeneID5359849.
KEGGpap:PSPA7_4749.
PATRIC19831060. VBIPseAer80442_4529.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246809.
KOK03685.
OMARACELPR.
ProtClustDBPRK00102.

Enzyme and pathway databases

BioCycPAER381754:GHMY-4777-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR001159. Ds-RNA-bd.
IPR014720. dsRNA-bd-like_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. RNase_III. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_PSEA7
AccessionPrimary (citable) accession number: A6VAK6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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