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A6V6F5

- HGD_PSEA7

UniProt

A6V6F5 - HGD_PSEA7

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Protein

Homogentisate 1,2-dioxygenase

Gene
hmgA, PSPA7_3280
Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei287 – 2871Proton acceptor By similarity
Metal bindingi330 – 3301Iron By similarity
Metal bindingi336 – 3361Iron By similarity
Binding sitei345 – 3451homogentisate By similarity
Metal bindingi366 – 3661Iron By similarity
Binding sitei366 – 3661homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciPAER381754:GHMY-3280-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:PSPA7_3280
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001582: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Homogentisate 1,2-dioxygenaseUniRule annotationPRO_1000019532Add
BLAST

Proteomic databases

PRIDEiA6V6F5.

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi381754.PSPA7_3280.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiDARTTER.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

A6V6F5-1 [UniParc]FASTAAdd to Basket

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MNLDSTALAY QSGFGNEFSS EALPGALPVG QNSPQKAPYG LYAELLSGTA    50
FTMARSEARR TWLYRITPSA KHPPFRRLER QIAGAELDAP TPNRLRWDPL 100
ALPEQPTDFL DGLLRMAANA PGDKPAGVSI YQYLANRSME RCFYDADGEL 150
LLVPQLGRLR LCTELGALQV EPLEIAVIPR GMKFRVELLD GEARGYIAEN 200
HGAPLRLPDL GPIGSNGLAN PRDFLAPVAR YEDSRQPLQL VQKYLGELWA 250
CELDHSPLDV VAWHGNNVPY KYDLRRFNTI GTVSFDHPDP SIFTVLTSPT 300
SVHGLANIDF VIFPPRWMVA ENTFRPPWFH RNLMNEFMGL IQGAYDAKAG 350
GFVPGGASLH SCMSAHGPDA ESCDKAIAAD LRPHRIDQTM AFMFETSQVL 400
RPSRAALETP ALQNDYDACW ASLVSTFNPQ RR 432
Length:432
Mass (Da):47,879
Last modified:August 21, 2007 - v1
Checksum:i674D3E4762E2E49C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR82657.1.
RefSeqiWP_012076024.1. NC_009656.1.
YP_001348640.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR82657; ABR82657; PSPA7_3280.
GeneIDi5353977.
KEGGipap:PSPA7_3280.
PATRICi19828222. VBIPseAer80442_3123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR82657.1 .
RefSeqi WP_012076024.1. NC_009656.1.
YP_001348640.1. NC_009656.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381754.PSPA7_3280.

Proteomic databases

PRIDEi A6V6F5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR82657 ; ABR82657 ; PSPA7_3280 .
GeneIDi 5353977.
KEGGi pap:PSPA7_3280.
PATRICi 19828222. VBIPseAer80442_3123.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi DARTTER.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci PAER381754:GHMY-3280-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Dodson R.J., Harkins D., Paulsen I.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA7.

Entry informationi

Entry nameiHGD_PSEA7
AccessioniPrimary (citable) accession number: A6V6F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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