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A6V4J2 (UVRC_PSEA7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:PSPA7_2614
OrganismPseudomonas aeruginosa (strain PA7) [Complete proteome] [HAMAP]
Taxonomic identifier381754 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 608608UvrABC system protein C HAMAP-Rule MF_00203
PRO_1000077818

Regions

Domain16 – 9479GIY-YIG
Domain204 – 23936UVR

Sequences

Sequence LengthMass (Da)Tools
A6V4J2 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: E1641C0266587384

FASTA60867,363
        10         20         30         40         50         60 
MTAVFDASAF LATCSNRPGV YRMFDADAKL LYVGKAKSLK KRLASYFRKS GLAPKTAALV 

        70         80         90        100        110        120 
VRIAQVETTI TANETEALLL EQTLIKEWRP PYNILLRDDK SYPFVFLSSE DEYPRLSLHR 

       130        140        150        160        170        180 
GAKKRKGRYF GPYPSAGAIR ESLNLLQKAF LVRQCEDSYF RNRTRPCLQY QIKRCKGPCV 

       190        200        210        220        230        240 
GLVGPEEYAE DVRHSVMFLE GRSNALADEL NTGMEQAAMR LDFEKAAELR DQVAILRRVQ 

       250        260        270        280        290        300 
DQQSMEGGNG DVDIVAAIVT PGGACVHLIS VRGGRVLGSK NFFPQVAIEE EVGEVLLAFL 

       310        320        330        340        350        360 
GQYYLSHQER DLPAELIVNV MHEDFPVLVA AIAEARGRQL EISYRVRGTR ARWQQLAVTN 

       370        380        390        400        410        420 
AEQALGARLA NRQHVAARFE ALAEALDLAE PPQRLECFDI SHSSGEATVA SCVVFGPEGP 

       430        440        450        460        470        480 
LKSDYRRYNI EGVTAGDDYA AMHQALTRRF SRLKEGEGKM PDILLVDGGK GQLAMAQEVL 

       490        500        510        520        530        540 
QELAVAGLIL LGVAKGVTRK PGLETLYLND AAHEFTLPAD SPALHLIQQI RDEAHRFAIT 

       550        560        570        580        590        600 
GHRARRGKAR RTSTLEDVPG VGPKRRRDLL KHFGGLQELS RASIDELAKA PGISKKLAEQ 


IYAVLHSE 

« Hide

References

[1]Dodson R.J., Harkins D., Paulsen I.T.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PA7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000744 Genomic DNA. Translation: ABR82671.1.
RefSeqYP_001347977.1. NC_009656.1.

3D structure databases

ProteinModelPortalA6V4J2.
SMRA6V4J2. Positions 552-602.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING381754.PSPA7_2614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR82671; ABR82671; PSPA7_2614.
GeneID5359552.
KEGGpap:PSPA7_2614.
PATRIC19826975. VBIPseAer80442_2504.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279961.
KOK03703.
OMASDVFDAK.
OrthoDBEOG6K13R9.

Enzyme and pathway databases

BioCycPAER381754:GHMY-2614-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_PSEA7
AccessionPrimary (citable) accession number: A6V4J2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families