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A6V4J2

- UVRC_PSEA7

UniProt

A6V4J2 - UVRC_PSEA7

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Protein
UvrABC system protein C
Gene
uvrC, PSPA7_2614
Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. SOS response Source: UniProtKB-HAMAP
  2. nucleotide-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciPAER381754:GHMY-2614-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein C
Short name:
Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene namesi
Name:uvrC
Ordered Locus Names:PSPA7_2614
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001582: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608UvrABC system protein CUniRule annotation
PRO_1000077818Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex By similarity.

Protein-protein interaction databases

STRINGi381754.PSPA7_2614.

Structurei

3D structure databases

ProteinModelPortaliA6V4J2.
SMRiA6V4J2. Positions 552-602.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9479GIY-YIG
Add
BLAST
Domaini204 – 23936UVR
Add
BLAST

Sequence similaritiesi

Belongs to the UvrC family.
Contains 1 GIY-YIG domain.
Contains 1 UVR domain.

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279961.
KOiK03703.
OMAiSDVFDAK.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6V4J2-1 [UniParc]FASTAAdd to Basket

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MTAVFDASAF LATCSNRPGV YRMFDADAKL LYVGKAKSLK KRLASYFRKS    50
GLAPKTAALV VRIAQVETTI TANETEALLL EQTLIKEWRP PYNILLRDDK 100
SYPFVFLSSE DEYPRLSLHR GAKKRKGRYF GPYPSAGAIR ESLNLLQKAF 150
LVRQCEDSYF RNRTRPCLQY QIKRCKGPCV GLVGPEEYAE DVRHSVMFLE 200
GRSNALADEL NTGMEQAAMR LDFEKAAELR DQVAILRRVQ DQQSMEGGNG 250
DVDIVAAIVT PGGACVHLIS VRGGRVLGSK NFFPQVAIEE EVGEVLLAFL 300
GQYYLSHQER DLPAELIVNV MHEDFPVLVA AIAEARGRQL EISYRVRGTR 350
ARWQQLAVTN AEQALGARLA NRQHVAARFE ALAEALDLAE PPQRLECFDI 400
SHSSGEATVA SCVVFGPEGP LKSDYRRYNI EGVTAGDDYA AMHQALTRRF 450
SRLKEGEGKM PDILLVDGGK GQLAMAQEVL QELAVAGLIL LGVAKGVTRK 500
PGLETLYLND AAHEFTLPAD SPALHLIQQI RDEAHRFAIT GHRARRGKAR 550
RTSTLEDVPG VGPKRRRDLL KHFGGLQELS RASIDELAKA PGISKKLAEQ 600
IYAVLHSE 608
Length:608
Mass (Da):67,363
Last modified:August 21, 2007 - v1
Checksum:iE1641C0266587384
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR82671.1.
RefSeqiWP_012075473.1. NC_009656.1.
YP_001347977.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR82671; ABR82671; PSPA7_2614.
GeneIDi5359552.
KEGGipap:PSPA7_2614.
PATRICi19826975. VBIPseAer80442_2504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR82671.1 .
RefSeqi WP_012075473.1. NC_009656.1.
YP_001347977.1. NC_009656.1.

3D structure databases

ProteinModelPortali A6V4J2.
SMRi A6V4J2. Positions 552-602.
ModBasei Search...

Protein-protein interaction databases

STRINGi 381754.PSPA7_2614.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR82671 ; ABR82671 ; PSPA7_2614 .
GeneIDi 5359552.
KEGGi pap:PSPA7_2614.
PATRICi 19826975. VBIPseAer80442_2504.

Phylogenomic databases

eggNOGi COG0322.
HOGENOMi HOG000279961.
KOi K03703.
OMAi SDVFDAK.
OrthoDBi EOG6K13R9.

Enzyme and pathway databases

BioCyci PAER381754:GHMY-2614-MONOMER.

Family and domain databases

Gene3Di 3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPi MF_00203. UvrC.
InterProi IPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view ]
Pfami PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view ]
SMARTi SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsi TIGR00194. uvrC. 1 hit.
PROSITEi PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Dodson R.J., Harkins D., Paulsen I.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA7.

Entry informationi

Entry nameiUVRC_PSEA7
AccessioniPrimary (citable) accession number: A6V4J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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