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A6V4J2

- UVRC_PSEA7

UniProt

A6V4J2 - UVRC_PSEA7

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Protein

UvrABC system protein C

Gene

uvrC

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciPAER381754:GHMY-2614-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:PSPA7_2614
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001582: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608UvrABC system protein CPRO_1000077818Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi381754.PSPA7_2614.

Structurei

3D structure databases

ProteinModelPortaliA6V4J2.
SMRiA6V4J2. Positions 552-602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9479GIY-YIGUniRule annotationAdd
BLAST
Domaini204 – 23936UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279961.
KOiK03703.
OMAiSDVFDAK.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6V4J2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAVFDASAF LATCSNRPGV YRMFDADAKL LYVGKAKSLK KRLASYFRKS
60 70 80 90 100
GLAPKTAALV VRIAQVETTI TANETEALLL EQTLIKEWRP PYNILLRDDK
110 120 130 140 150
SYPFVFLSSE DEYPRLSLHR GAKKRKGRYF GPYPSAGAIR ESLNLLQKAF
160 170 180 190 200
LVRQCEDSYF RNRTRPCLQY QIKRCKGPCV GLVGPEEYAE DVRHSVMFLE
210 220 230 240 250
GRSNALADEL NTGMEQAAMR LDFEKAAELR DQVAILRRVQ DQQSMEGGNG
260 270 280 290 300
DVDIVAAIVT PGGACVHLIS VRGGRVLGSK NFFPQVAIEE EVGEVLLAFL
310 320 330 340 350
GQYYLSHQER DLPAELIVNV MHEDFPVLVA AIAEARGRQL EISYRVRGTR
360 370 380 390 400
ARWQQLAVTN AEQALGARLA NRQHVAARFE ALAEALDLAE PPQRLECFDI
410 420 430 440 450
SHSSGEATVA SCVVFGPEGP LKSDYRRYNI EGVTAGDDYA AMHQALTRRF
460 470 480 490 500
SRLKEGEGKM PDILLVDGGK GQLAMAQEVL QELAVAGLIL LGVAKGVTRK
510 520 530 540 550
PGLETLYLND AAHEFTLPAD SPALHLIQQI RDEAHRFAIT GHRARRGKAR
560 570 580 590 600
RTSTLEDVPG VGPKRRRDLL KHFGGLQELS RASIDELAKA PGISKKLAEQ

IYAVLHSE
Length:608
Mass (Da):67,363
Last modified:August 21, 2007 - v1
Checksum:iE1641C0266587384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR82671.1.
RefSeqiYP_001347977.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR82671; ABR82671; PSPA7_2614.
GeneIDi5359552.
KEGGipap:PSPA7_2614.
PATRICi19826975. VBIPseAer80442_2504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR82671.1 .
RefSeqi YP_001347977.1. NC_009656.1.

3D structure databases

ProteinModelPortali A6V4J2.
SMRi A6V4J2. Positions 552-602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381754.PSPA7_2614.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR82671 ; ABR82671 ; PSPA7_2614 .
GeneIDi 5359552.
KEGGi pap:PSPA7_2614.
PATRICi 19826975. VBIPseAer80442_2504.

Phylogenomic databases

eggNOGi COG0322.
HOGENOMi HOG000279961.
KOi K03703.
OMAi SDVFDAK.
OrthoDBi EOG6K13R9.

Enzyme and pathway databases

BioCyci PAER381754:GHMY-2614-MONOMER.

Family and domain databases

Gene3Di 3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPi MF_00203. UvrC.
InterProi IPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view ]
Pfami PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view ]
SMARTi SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsi TIGR00194. uvrC. 1 hit.
PROSITEi PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Dodson R.J., Harkins D., Paulsen I.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA7.

Entry informationi

Entry nameiUVRC_PSEA7
AccessioniPrimary (citable) accession number: A6V4J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3