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A6V4J2

- UVRC_PSEA7

UniProt

A6V4J2 - UVRC_PSEA7

Protein

UvrABC system protein C

Gene

uvrC

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. excinuclease ABC activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Enzyme and pathway databases

    BioCyciPAER381754:GHMY-2614-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein CUniRule annotation
    Short name:
    Protein UvrCUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit CUniRule annotation
    Gene namesi
    Name:uvrCUniRule annotation
    Ordered Locus Names:PSPA7_2614
    OrganismiPseudomonas aeruginosa (strain PA7)
    Taxonomic identifieri381754 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000001582: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. excinuclease repair complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 608608UvrABC system protein CPRO_1000077818Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with UvrB in an incision complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi381754.PSPA7_2614.

    Structurei

    3D structure databases

    ProteinModelPortaliA6V4J2.
    SMRiA6V4J2. Positions 552-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 9479GIY-YIGUniRule annotationAdd
    BLAST
    Domaini204 – 23936UVRUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UvrC family.UniRule annotation
    Contains 1 GIY-YIG domain.UniRule annotation
    Contains 1 UVR domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0322.
    HOGENOMiHOG000279961.
    KOiK03703.
    OMAiSDVFDAK.
    OrthoDBiEOG6K13R9.

    Family and domain databases

    Gene3Di3.40.1440.10. 1 hit.
    4.10.860.10. 1 hit.
    HAMAPiMF_00203. UvrC.
    InterProiIPR027299. GIY-YIG_dom.
    IPR000305. GIY-YIG_SF.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR010994. RuvA_2-like.
    IPR001943. UVR_dom.
    IPR004791. UvrC.
    IPR001162. UvrC_homol_region.
    [Graphical view]
    PfamiPF01541. GIY-YIG. 1 hit.
    PF02151. UVR. 1 hit.
    PF08459. UvrC_HhH_N. 1 hit.
    [Graphical view]
    SMARTiSM00465. GIYc. 1 hit.
    SM00278. HhH1. 2 hits.
    [Graphical view]
    SUPFAMiSSF46600. SSF46600. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF82771. SSF82771. 1 hit.
    TIGRFAMsiTIGR00194. uvrC. 1 hit.
    PROSITEiPS50164. GIY_YIG. 1 hit.
    PS50151. UVR. 1 hit.
    PS50165. UVRC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6V4J2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAVFDASAF LATCSNRPGV YRMFDADAKL LYVGKAKSLK KRLASYFRKS    50
    GLAPKTAALV VRIAQVETTI TANETEALLL EQTLIKEWRP PYNILLRDDK 100
    SYPFVFLSSE DEYPRLSLHR GAKKRKGRYF GPYPSAGAIR ESLNLLQKAF 150
    LVRQCEDSYF RNRTRPCLQY QIKRCKGPCV GLVGPEEYAE DVRHSVMFLE 200
    GRSNALADEL NTGMEQAAMR LDFEKAAELR DQVAILRRVQ DQQSMEGGNG 250
    DVDIVAAIVT PGGACVHLIS VRGGRVLGSK NFFPQVAIEE EVGEVLLAFL 300
    GQYYLSHQER DLPAELIVNV MHEDFPVLVA AIAEARGRQL EISYRVRGTR 350
    ARWQQLAVTN AEQALGARLA NRQHVAARFE ALAEALDLAE PPQRLECFDI 400
    SHSSGEATVA SCVVFGPEGP LKSDYRRYNI EGVTAGDDYA AMHQALTRRF 450
    SRLKEGEGKM PDILLVDGGK GQLAMAQEVL QELAVAGLIL LGVAKGVTRK 500
    PGLETLYLND AAHEFTLPAD SPALHLIQQI RDEAHRFAIT GHRARRGKAR 550
    RTSTLEDVPG VGPKRRRDLL KHFGGLQELS RASIDELAKA PGISKKLAEQ 600
    IYAVLHSE 608
    Length:608
    Mass (Da):67,363
    Last modified:August 21, 2007 - v1
    Checksum:iE1641C0266587384
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000744 Genomic DNA. Translation: ABR82671.1.
    RefSeqiWP_012075473.1. NC_009656.1.
    YP_001347977.1. NC_009656.1.

    Genome annotation databases

    EnsemblBacteriaiABR82671; ABR82671; PSPA7_2614.
    GeneIDi5359552.
    KEGGipap:PSPA7_2614.
    PATRICi19826975. VBIPseAer80442_2504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000744 Genomic DNA. Translation: ABR82671.1 .
    RefSeqi WP_012075473.1. NC_009656.1.
    YP_001347977.1. NC_009656.1.

    3D structure databases

    ProteinModelPortali A6V4J2.
    SMRi A6V4J2. Positions 552-602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381754.PSPA7_2614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR82671 ; ABR82671 ; PSPA7_2614 .
    GeneIDi 5359552.
    KEGGi pap:PSPA7_2614.
    PATRICi 19826975. VBIPseAer80442_2504.

    Phylogenomic databases

    eggNOGi COG0322.
    HOGENOMi HOG000279961.
    KOi K03703.
    OMAi SDVFDAK.
    OrthoDBi EOG6K13R9.

    Enzyme and pathway databases

    BioCyci PAER381754:GHMY-2614-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1440.10. 1 hit.
    4.10.860.10. 1 hit.
    HAMAPi MF_00203. UvrC.
    InterProi IPR027299. GIY-YIG_dom.
    IPR000305. GIY-YIG_SF.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR010994. RuvA_2-like.
    IPR001943. UVR_dom.
    IPR004791. UvrC.
    IPR001162. UvrC_homol_region.
    [Graphical view ]
    Pfami PF01541. GIY-YIG. 1 hit.
    PF02151. UVR. 1 hit.
    PF08459. UvrC_HhH_N. 1 hit.
    [Graphical view ]
    SMARTi SM00465. GIYc. 1 hit.
    SM00278. HhH1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46600. SSF46600. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF82771. SSF82771. 1 hit.
    TIGRFAMsi TIGR00194. uvrC. 1 hit.
    PROSITEi PS50164. GIY_YIG. 1 hit.
    PS50151. UVR. 1 hit.
    PS50165. UVRC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Dodson R.J., Harkins D., Paulsen I.T.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PA7.

    Entry informationi

    Entry nameiUVRC_PSEA7
    AccessioniPrimary (citable) accession number: A6V4J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3