A6V4J2 (UVRC_PSEA7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UvrABC system protein C
Short name=Protein UvrC

Alternative name(s):
Excinuclease ABC subunit C

Gene names

Name:	uvrC
Ordered Locus Names:	PSPA7_2614

Organism

Pseudomonas aeruginosa (strain PA7) [Complete proteome] [HAMAP]

Taxonomic identifier

381754 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa group › Pseudomonas aeruginosa

Protein attributes

Sequence length	608 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203
Subunit structure	Interacts with UvrB in an incision complex By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the UvrC family. Contains 1 GIY-YIG domain. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	SOS response Inferred from electronic annotation. Source: HAMAP nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 608	608	UvrABC system protein C HAMAP-Rule MF_00203		PRO_1000077818
Regions
	Domain	16 – 94	79	GIY-YIG
	Domain	204 – 239	36	UVR

Sequences

	Sequence		Length	Mass (Da)
	A6V4J2 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: E1641C0266587384	FASTA	608	67,363
	10 20 30 40 50 60 MTAVFDASAF LATCSNRPGV YRMFDADAKL LYVGKAKSLK KRLASYFRKS GLAPKTAALV 70 80 90 100 110 120 VRIAQVETTI TANETEALLL EQTLIKEWRP PYNILLRDDK SYPFVFLSSE DEYPRLSLHR 130 140 150 160 170 180 GAKKRKGRYF GPYPSAGAIR ESLNLLQKAF LVRQCEDSYF RNRTRPCLQY QIKRCKGPCV 190 200 210 220 230 240 GLVGPEEYAE DVRHSVMFLE GRSNALADEL NTGMEQAAMR LDFEKAAELR DQVAILRRVQ 250 260 270 280 290 300 DQQSMEGGNG DVDIVAAIVT PGGACVHLIS VRGGRVLGSK NFFPQVAIEE EVGEVLLAFL 310 320 330 340 350 360 GQYYLSHQER DLPAELIVNV MHEDFPVLVA AIAEARGRQL EISYRVRGTR ARWQQLAVTN 370 380 390 400 410 420 AEQALGARLA NRQHVAARFE ALAEALDLAE PPQRLECFDI SHSSGEATVA SCVVFGPEGP 430 440 450 460 470 480 LKSDYRRYNI EGVTAGDDYA AMHQALTRRF SRLKEGEGKM PDILLVDGGK GQLAMAQEVL 490 500 510 520 530 540 QELAVAGLIL LGVAKGVTRK PGLETLYLND AAHEFTLPAD SPALHLIQQI RDEAHRFAIT 550 560 570 580 590 600 GHRARRGKAR RTSTLEDVPG VGPKRRRDLL KHFGGLQELS RASIDELAKA PGISKKLAEQ IYAVLHSE

References

[1]	Dodson R.J., Harkins D., Paulsen I.T. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PA7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000744 Genomic DNA. Translation: ABR82671.1.
RefSeq	YP_001347977.1. NC_009656.1.
3D structure databases
ProteinModelPortal	A6V4J2.
SMR	A6V4J2. Positions 552-602.
ModBase	Search...
Protein-protein interaction databases
STRING	381754.PSPA7_2614.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR82671; ABR82671; PSPA7_2614.
GeneID	5359552.
KEGG	pap:PSPA7_2614.
PATRIC	19826975. VBIPseAer80442_2504.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0322.
HOGENOM	HOG000279961.
KO	K03703.
OMA	QKLFPIR.
ProtClustDB	PRK00558.
Enzyme and pathway databases
BioCyc	PAER381754:GHMY-2659-MONOMER.
Family and domain databases
Gene3D	3.40.1440.10. 1 hit. 4.10.860.10. 1 hit.
HAMAP	MF_00203. UvrC.
InterPro	IPR027299. GIY-YIG_dom. IPR000305. GIY-YIG_SF. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR010994. RuvA_2-like. IPR001943. UVR_dom. IPR004791. UvrC. IPR001162. UvrC_homol_region. [Graphical view]
Pfam	PF01541. GIY-YIG. 1 hit. PF02151. UVR. 1 hit. PF08459. UvrC_HhH_N. 1 hit. [Graphical view]
SMART	SM00465. GIYc. 1 hit. SM00278. HhH1. 2 hits. [Graphical view]
SUPFAM	SSF47781. RuvA_2_like. 1 hit. SSF46600. UvrB_C. 1 hit. SSF82771. UvrC_N. 1 hit.
TIGRFAMs	TIGR00194. uvrC. 1 hit.
PROSITE	PS50164. GIY_YIG. 1 hit. PS50151. UVR. 1 hit. PS50165. UVRC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRC_PSEA7

Accession

Primary (citable) accession number: A6V4J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program