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A6V4G3

- A6V4G3_PSEA7

UniProt

A6V4G3 - A6V4G3_PSEA7

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, PSPA7_2584
Organism
Pseudomonas aeruginosa (strain PA7)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPAER381754:GHMY-2584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:PSPA7_2584Imported
OrganismiPseudomonas aeruginosa (strain PA7)Imported
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001582: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi381754.PSPA7_2584.

Structurei

3D structure databases

ProteinModelPortaliA6V4G3.
SMRiA6V4G3. Positions 5-418.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6V4G3-1 [UniParc]FASTAAdd to Basket

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MGYQKIQVPA TGDKITVNAD MSLSVPKNPI IPFIEGDGIG VDISPVMIKV    50
VDAAVEKAYK GERKIAWMEV YAGEKATQVY DQDTWLPQET LDAVRDYVVS 100
IKGPLTTPVG GGIRSLNVAL RQQLDLYVCQ RPVRWFEGVP SPVKKPGDVD 150
MVIFRENSED IYAGVEWKAG SPEAEKVIKF LTEEMGVKKI RFTENCGIGI 200
KPVSQEGTKR LVRKALQYAV DNDRSSVTLV HKGNIMKFTE GAFKDWGYEV 250
ARDEFGAELL DGGPWMQFKN PKTGRNVVVK DVIADAMLQQ ILLRPAEYDV 300
IATLNLNGDY LSDALAAEVG GIGIAPGANL SDSVAMFEAT HGTAPKYAGQ 350
DKVNPGSLIL SAEMMLRHMG WTEAADLIIK GTNGAIAAKT VTYDFERLMD 400
GATLLSCSEF GDAMIAKM 418
Length:418
Mass (Da):45,605
Last modified:August 21, 2007 - v1
Checksum:iC314448CF03C75F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR82501.1.
RefSeqiWP_012075454.1. NC_009656.1.
YP_001347948.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR82501; ABR82501; PSPA7_2584.
GeneIDi5356208.
KEGGipap:PSPA7_2584.
PATRICi19826915. VBIPseAer80442_2475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR82501.1 .
RefSeqi WP_012075454.1. NC_009656.1.
YP_001347948.1. NC_009656.1.

3D structure databases

ProteinModelPortali A6V4G3.
SMRi A6V4G3. Positions 5-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381754.PSPA7_2584.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR82501 ; ABR82501 ; PSPA7_2584 .
GeneIDi 5356208.
KEGGi pap:PSPA7_2584.
PATRICi 19826915. VBIPseAer80442_2475.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci PAER381754:GHMY-2584-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Dodson R.J., Harkins D., Paulsen I.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA7Imported.

Entry informationi

Entry nameiA6V4G3_PSEA7
AccessioniPrimary (citable) accession number: A6V4G3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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