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A6V4G3

- A6V4G3_PSEA7

UniProt

A6V4G3 - A6V4G3_PSEA7

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciPAER381754:GHMY-2584-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:PSPA7_2584Imported
    OrganismiPseudomonas aeruginosa (strain PA7)Imported
    Taxonomic identifieri381754 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000001582: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi381754.PSPA7_2584.

    Structurei

    3D structure databases

    ProteinModelPortaliA6V4G3.
    SMRiA6V4G3. Positions 5-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6V4G3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYQKIQVPA TGDKITVNAD MSLSVPKNPI IPFIEGDGIG VDISPVMIKV    50
    VDAAVEKAYK GERKIAWMEV YAGEKATQVY DQDTWLPQET LDAVRDYVVS 100
    IKGPLTTPVG GGIRSLNVAL RQQLDLYVCQ RPVRWFEGVP SPVKKPGDVD 150
    MVIFRENSED IYAGVEWKAG SPEAEKVIKF LTEEMGVKKI RFTENCGIGI 200
    KPVSQEGTKR LVRKALQYAV DNDRSSVTLV HKGNIMKFTE GAFKDWGYEV 250
    ARDEFGAELL DGGPWMQFKN PKTGRNVVVK DVIADAMLQQ ILLRPAEYDV 300
    IATLNLNGDY LSDALAAEVG GIGIAPGANL SDSVAMFEAT HGTAPKYAGQ 350
    DKVNPGSLIL SAEMMLRHMG WTEAADLIIK GTNGAIAAKT VTYDFERLMD 400
    GATLLSCSEF GDAMIAKM 418
    Length:418
    Mass (Da):45,605
    Last modified:August 21, 2007 - v1
    Checksum:iC314448CF03C75F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000744 Genomic DNA. Translation: ABR82501.1.
    RefSeqiWP_012075454.1. NC_009656.1.
    YP_001347948.1. NC_009656.1.

    Genome annotation databases

    EnsemblBacteriaiABR82501; ABR82501; PSPA7_2584.
    GeneIDi5356208.
    KEGGipap:PSPA7_2584.
    PATRICi19826915. VBIPseAer80442_2475.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000744 Genomic DNA. Translation: ABR82501.1 .
    RefSeqi WP_012075454.1. NC_009656.1.
    YP_001347948.1. NC_009656.1.

    3D structure databases

    ProteinModelPortali A6V4G3.
    SMRi A6V4G3. Positions 5-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381754.PSPA7_2584.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR82501 ; ABR82501 ; PSPA7_2584 .
    GeneIDi 5356208.
    KEGGi pap:PSPA7_2584.
    PATRICi 19826915. VBIPseAer80442_2475.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci PAER381754:GHMY-2584-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Dodson R.J., Harkins D., Paulsen I.T.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PA7Imported.

    Entry informationi

    Entry nameiA6V4G3_PSEA7
    AccessioniPrimary (citable) accession number: A6V4G3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3