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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:PSPA7_2246
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000001582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000468741 – 366Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST366

Structurei

3D structure databases

ProteinModelPortaliA6V3I3
SMRiA6V3I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

A6V3I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREETPEQPA PLRSGYTTGS CATATSLAAA RLLLGGTTSD AVRIVLPKGQ
60 70 80 90 100
QVPMRLEFCR AWENGAEAGT LKDAGDDPDV THGALVFARV RLSAAPGVRF
110 120 130 140 150
HAGPGVGTVT RPGLTLAVGE PAINPVPRQM MERHLTQLAA EHGYTGGFEV
160 170 180 190 200
TIGIEGGEAL ALKTMNPRLG ILGGLSILGT SGIVRPFSCS AYIASIHQGI
210 220 230 240 250
DVARANGVRH IAACTGNASE DAMRRRYALP EIALIEMGDF AGAVLKHLRK
260 270 280 290 300
APVEKLSLCG GFGKISKLAG GHLDLHSRHS SIDLPQLAGW AAALGASAAL
310 320 330 340 350
QQSMRAANTS QQALAQAHAE GVALGDAVCA HALRFARSIV PAEVRLEVFA
360
IDRQGNLVGQ AGEERS
Length:366
Mass (Da):38,116
Last modified:August 21, 2007 - v1
Checksum:i66172DDE082E7617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA Translation: ABR83002.1
RefSeqiWP_012075213.1, NC_009656.1

Genome annotation databases

EnsemblBacteriaiABR83002; ABR83002; PSPA7_2246
KEGGipap:PSPA7_2246

Similar proteinsi

Entry informationi

Entry nameiCBID_PSEA7
AccessioniPrimary (citable) accession number: A6V3I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health