A6V1P7 (ALGL_PSEA7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alginate lyase
EC=4.2.2.3

Alternative name(s):
Poly(beta-D-mannuronate) lyase
Poly(mana) alginate lyase

Gene names

Name:	algL
Ordered Locus Names:	PSPA7_1598

Organism

Pseudomonas aeruginosa (strain PA7) [Complete proteome] [HAMAP]

Taxonomic identifier

381754 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa group › Pseudomonas aeruginosa

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Depolymerizes alginate by cleaving the beta-1,4 glycosidic bond By similarity. HAMAP-Rule MF_00557
Catalytic activity	Eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their non-reducing ends. HAMAP-Rule MF_00557
Subcellular location	Periplasm Potential HAMAP-Rule MF_00557.
Sequence similarities	Belongs to the polysaccharide lyase 5 family.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	alginic acid catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	poly(beta-D-mannuronate) lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 367	340	Alginate lyase HAMAP-Rule MF_00557		PRO_1000061109

Sequences

	Sequence		Length	Mass (Da)
	A6V1P7 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 35ADE8EA39809C48	FASTA	367	40,774
	10 20 30 40 50 60 MKTSHLIRIT LPGALAAALL ASQVSQAADL VPPPGYYAAV GERKGSAGSC PSVPPPYTGS 70 80 90 100 110 120 LVFTSKYEGS DSARATLNAK AEKAFRSQIK DITDMERGAT KLVTQYMRSG RDGDLVCALN 130 140 150 160 170 180 WMSAWARAGA LQSDDFNHTG KSMRKWALGS LSGAYMRLKF SSSRPLSAHA GQSREIEDWF 190 200 210 220 230 240 ARLGTQVVRD WSNLPLKKIN NHSYWAAWSV MSTAVVTNRR DLFDWAVSEF KVAANQVDEQ 250 260 270 280 290 300 GFLPNELKRR QRALAYHNYA LPPLAMIAAF AQVNGVDLRQ ENHGALQRLA ERVMNGVDDE 310 320 330 340 350 360 ETFEEKTGED QDMTDLKVDN KYAWLEPYCA LYRCAPKMLE AKKDREPFNS FRLGGEVTRV FSREGGS

References

[1]	Dodson R.J., Harkins D., Paulsen I.T. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PA7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000744 Genomic DNA. Translation: ABR80788.1.
RefSeq	YP_001346982.1. NC_009656.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	381754.PSPA7_1598.
Protein family/group databases
CAZy	PL5. Polysaccharide Lyase Family 5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR80788; ABR80788; PSPA7_1598.
GeneID	5359375.
KEGG	pap:PSPA7_1598.
PATRIC	19825005. VBIPseAer80442_1539.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG42597.
HOGENOM	HOG000247392.
KO	K01729.
OMA	AAWSVMA.
ProtClustDB	PRK00325.
Enzyme and pathway databases
BioCyc	PAER381754:GHMY-1598-MONOMER.
Family and domain databases
Gene3D	1.50.10.110. 1 hit.
HAMAP	MF_00557. Alginate_lyase.
InterPro	IPR022859. Alginate_lyase. IPR008397. Alginate_lyase_dom. IPR008929. Chondroitin_lyas. [Graphical view]
Pfam	PF05426. Alginate_lyase. 1 hit. [Graphical view]
SUPFAM	SSF48230. Chondroitin_lyas. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALGL_PSEA7

Accession

Primary (citable) accession number: A6V1P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	May 29, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program