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A6V1N9

- ARND_PSEA7

UniProt

A6V1N9 - ARND_PSEA7

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Protein

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Gene

arnD

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP

GO - Biological processi

  1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipid A biosynthetic process Source: UniProtKB-HAMAP
  3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
  4. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciPAER381754:GHMY-1590-MONOMER.
UniPathwayiUPA00030.
UPA00036; UER00496.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
Gene namesi
Name:arnDUniRule annotation
Ordered Locus Names:PSPA7_1590
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001582: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDPRO_0000383521Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381754.PSPA7_1590.

Structurei

3D structure databases

ProteinModelPortaliA6V1N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 260259NodB homologyUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation
Contains 1 NodB homology domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0726.
HOGENOMiHOG000261199.
KOiK13014.
OMAiLHAWDHF.
OrthoDBiEOG6423D0.

Family and domain databases

Gene3Di3.20.20.370. 2 hits.
HAMAPiMF_01870. ArnD.
InterProiIPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 2 hits.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6V1N9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQAGLRIDV DTFRGTRDGV PRLLDLLDEA GLKATFFFSV GPDNMGRHLW
60 70 80 90 100
RLARPAFLWK MLRSRAASLY GWDILLAGTA WPGKPIGREL GPLMRRTQAA
110 120 130 140 150
GHEVGLHAWD HHAWQTHAGV WSAQQLGEQI RRGSDCLADI LGQPVRCSAA
160 170 180 190 200
AGWRADGRVV EAKQPFGFRY NSDCRGRGAF RPRLADGSPG IPQVPVNLPT
210 220 230 240 250
FDEVVGPGLP REAYNDFILE RFAAGRDNVY TIHAEVEGLL LAPAFRELLR
260 270 280 290
RAERRGIRFR PLGELLPDDP RSLPLAELVR GRLAGREGWL GVRQP
Length:295
Mass (Da):32,844
Last modified:August 21, 2007 - v1
Checksum:iB55605CA65C45A37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR81600.1.
RefSeqiYP_001346974.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR81600; ABR81600; PSPA7_1590.
GeneIDi5354219.
KEGGipap:PSPA7_1590.
PATRICi19824989. VBIPseAer80442_1531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR81600.1 .
RefSeqi YP_001346974.1. NC_009656.1.

3D structure databases

ProteinModelPortali A6V1N9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381754.PSPA7_1590.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR81600 ; ABR81600 ; PSPA7_1590 .
GeneIDi 5354219.
KEGGi pap:PSPA7_1590.
PATRICi 19824989. VBIPseAer80442_1531.

Phylogenomic databases

eggNOGi COG0726.
HOGENOMi HOG000261199.
KOi K13014.
OMAi LHAWDHF.
OrthoDBi EOG6423D0.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00036 ; UER00496 .
BioCyci PAER381754:GHMY-1590-MONOMER.

Family and domain databases

Gene3Di 3.20.20.370. 2 hits.
HAMAPi MF_01870. ArnD.
InterProi IPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view ]
Pfami PF01522. Polysacc_deac_1. 1 hit.
[Graphical view ]
SUPFAMi SSF88713. SSF88713. 2 hits.
PROSITEi PS51677. NODB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Dodson R.J., Harkins D., Paulsen I.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA7.

Entry informationi

Entry nameiARND_PSEA7
AccessioniPrimary (citable) accession number: A6V1N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: August 21, 2007
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3