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A6V1K5

- METE_PSEA7

UniProt

A6V1K5 - METE_PSEA7

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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene
metE, PSPA7_1556
Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity.UniRule annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi648 – 6481Zinc By similarity
Metal bindingi650 – 6501Zinc By similarity
Metal bindingi733 – 7331Zinc By similarity

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciPAER381754:GHMY-1556-MONOMER.
UniPathwayiUPA00051; UER00082.

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC:2.1.1.14)
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene namesi
Name:metE
Ordered Locus Names:PSPA7_1556
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001582: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7637635-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotationPRO_1000017261Add
BLAST

Proteomic databases

PRIDEiA6V1K5.

Interactioni

Protein-protein interaction databases

STRINGi381754.PSPA7_1556.

Structurei

3D structure databases

ProteinModelPortaliA6V1K5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0620.
HOGENOMiHOG000246221.
KOiK00549.
OMAiFKANPAH.
OrthoDBiEOG6FFS3G.

Family and domain databases

HAMAPiMF_00172. Meth_synth.
InterProiIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view]
PfamiPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

Sequencei

Sequence statusi: Complete.

A6V1K5-1 [UniParc]FASTAAdd to Basket

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MALAHTLGFP RIGRDRELKK ALEAYWKGEL DQPGLLQVGR ELRRQHWQLQ    50
KDAGIELLPV GDFAWYDQVL AHSLAFGVIP ERFRPADGQP TLDTLFAMAR 100
GVAQGCCGGA HAQEMTKWFD TNYHYLVPEF TVDQAFSLSW TQLFEEVDEA 150
LALGHAVKPV LIGPLSYLWL GKAKGGEFDR LELLERLLPV YGEIFQGLAA 200
RGVEWVQIDE PILVLDLPQA WKNAFERAYN LIQREPLKKL VATYFGGLED 250
NLGLAAGLPV DGLHIDLVRA PGQYPTILDR LPAYKVLSLG LVNGRNVWRC 300
DLEKALEVLA HAHERLGERL WVAPSCSLLH SPVDLCREDQ LDEELQSWLA 350
FAVQKCEEVA ILARALVEPE APEVRQAFEV SRRVEASRRR STRIHKREVQ 400
ARLAAVRPQD SRRASAFAER AVQQRARLEL PAFPTTTIGS FPQTSAIRLA 450
RQSWKQGRLS QAEYTEAMHS EIRHAVQVQE RLGLDVLVHG EAERNDMVEY 500
FAEQLDGYAF TRFGWVQSYG SRCVKPAVIY GDLSRPRPMT VEWIRYAQSL 550
TGKVMKGMLT GPVTMLMWSF PREDVSREVQ ARQLALALRD EVSDLEQAGI 600
RIVQIDEAAF REGLPLRRAD WPHYLEWATE AFRLCASGVR DETQIHTHMC 650
YSEFNDVIES IAAMDADVIT IETSRSDMEL LEAFEAFAYP NEIGPGVYDI 700
HSPRVPAVED MVKLLSKAAE RIPAARLWVN PDCGLKTRAW AETEAALANM 750
VAAARQLRQA NLA 763
Length:763
Mass (Da):86,085
Last modified:August 21, 2007 - v1
Checksum:i7F5BA32D334ED4FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR84681.1.
RefSeqiWP_012074732.1. NC_009656.1.
YP_001346940.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR84681; ABR84681; PSPA7_1556.
GeneIDi5355798.
KEGGipap:PSPA7_1556.
PATRICi19824923. VBIPseAer80442_1498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000744 Genomic DNA. Translation: ABR84681.1 .
RefSeqi WP_012074732.1. NC_009656.1.
YP_001346940.1. NC_009656.1.

3D structure databases

ProteinModelPortali A6V1K5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381754.PSPA7_1556.

Proteomic databases

PRIDEi A6V1K5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR84681 ; ABR84681 ; PSPA7_1556 .
GeneIDi 5355798.
KEGGi pap:PSPA7_1556.
PATRICi 19824923. VBIPseAer80442_1498.

Phylogenomic databases

eggNOGi COG0620.
HOGENOMi HOG000246221.
KOi K00549.
OMAi FKANPAH.
OrthoDBi EOG6FFS3G.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00082 .
BioCyci PAER381754:GHMY-1556-MONOMER.

Family and domain databases

HAMAPi MF_00172. Meth_synth.
InterProi IPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view ]
Pfami PF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Dodson R.J., Harkins D., Paulsen I.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA7.

Entry informationi

Entry nameiMETE_PSEA7
AccessioniPrimary (citable) accession number: A6V1K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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