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A6V1K5 (METE_PSEA7) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:PSPA7_1556
OrganismPseudomonas aeruginosa (strain PA7) [Complete proteome] [HAMAP]
Taxonomic identifier381754 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP-Rule MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP-Rule MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP-Rule MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7637635-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP-Rule MF_00172
PRO_1000017261

Sites

Metal binding6481Zinc By similarity
Metal binding6501Zinc By similarity
Metal binding7331Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A6V1K5 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 7F5BA32D334ED4FB

FASTA76386,085
        10         20         30         40         50         60 
MALAHTLGFP RIGRDRELKK ALEAYWKGEL DQPGLLQVGR ELRRQHWQLQ KDAGIELLPV 

        70         80         90        100        110        120 
GDFAWYDQVL AHSLAFGVIP ERFRPADGQP TLDTLFAMAR GVAQGCCGGA HAQEMTKWFD 

       130        140        150        160        170        180 
TNYHYLVPEF TVDQAFSLSW TQLFEEVDEA LALGHAVKPV LIGPLSYLWL GKAKGGEFDR 

       190        200        210        220        230        240 
LELLERLLPV YGEIFQGLAA RGVEWVQIDE PILVLDLPQA WKNAFERAYN LIQREPLKKL 

       250        260        270        280        290        300 
VATYFGGLED NLGLAAGLPV DGLHIDLVRA PGQYPTILDR LPAYKVLSLG LVNGRNVWRC 

       310        320        330        340        350        360 
DLEKALEVLA HAHERLGERL WVAPSCSLLH SPVDLCREDQ LDEELQSWLA FAVQKCEEVA 

       370        380        390        400        410        420 
ILARALVEPE APEVRQAFEV SRRVEASRRR STRIHKREVQ ARLAAVRPQD SRRASAFAER 

       430        440        450        460        470        480 
AVQQRARLEL PAFPTTTIGS FPQTSAIRLA RQSWKQGRLS QAEYTEAMHS EIRHAVQVQE 

       490        500        510        520        530        540 
RLGLDVLVHG EAERNDMVEY FAEQLDGYAF TRFGWVQSYG SRCVKPAVIY GDLSRPRPMT 

       550        560        570        580        590        600 
VEWIRYAQSL TGKVMKGMLT GPVTMLMWSF PREDVSREVQ ARQLALALRD EVSDLEQAGI 

       610        620        630        640        650        660 
RIVQIDEAAF REGLPLRRAD WPHYLEWATE AFRLCASGVR DETQIHTHMC YSEFNDVIES 

       670        680        690        700        710        720 
IAAMDADVIT IETSRSDMEL LEAFEAFAYP NEIGPGVYDI HSPRVPAVED MVKLLSKAAE 

       730        740        750        760 
RIPAARLWVN PDCGLKTRAW AETEAALANM VAAARQLRQA NLA 

« Hide

References

[1]Dodson R.J., Harkins D., Paulsen I.T.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PA7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000744 Genomic DNA. Translation: ABR84681.1.
RefSeqYP_001346940.1. NC_009656.1.

3D structure databases

ProteinModelPortalA6V1K5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING381754.PSPA7_1556.

Proteomic databases

PRIDEA6V1K5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR84681; ABR84681; PSPA7_1556.
GeneID5355798.
KEGGpap:PSPA7_1556.
PATRIC19824923. VBIPseAer80442_1498.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0620.
HOGENOMHOG000246221.
KOK00549.
OMAFKANPAH.
OrthoDBEOG6FFS3G.

Enzyme and pathway databases

BioCycPAER381754:GHMY-1556-MONOMER.
UniPathwayUPA00051; UER00082.

Family and domain databases

HAMAPMF_00172. Meth_synth.
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view]
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_PSEA7
AccessionPrimary (citable) accession number: A6V1K5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways