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A6V1K5

- METE_PSEA7

UniProt

A6V1K5 - METE_PSEA7

Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotation

    Catalytic activityi

    5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi648 – 6481ZincUniRule annotation
    Metal bindingi650 – 6501ZincUniRule annotation
    Metal bindingi733 – 7331ZincUniRule annotation

    GO - Molecular functioni

    1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. methionine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciPAER381754:GHMY-1556-MONOMER.
    UniPathwayiUPA00051; UER00082.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
    Alternative name(s):
    Cobalamin-independent methionine synthaseUniRule annotation
    Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
    Gene namesi
    Name:metEUniRule annotation
    Ordered Locus Names:PSPA7_1556
    OrganismiPseudomonas aeruginosa (strain PA7)
    Taxonomic identifieri381754 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000001582: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7637635-methyltetrahydropteroyltriglutamate--homocysteine methyltransferasePRO_1000017261Add
    BLAST

    Proteomic databases

    PRIDEiA6V1K5.

    Interactioni

    Protein-protein interaction databases

    STRINGi381754.PSPA7_1556.

    Structurei

    3D structure databases

    ProteinModelPortaliA6V1K5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0620.
    HOGENOMiHOG000246221.
    KOiK00549.
    OMAiFKANPAH.
    OrthoDBiEOG6FFS3G.

    Family and domain databases

    HAMAPiMF_00172. Meth_synth.
    InterProiIPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view]
    PfamiPF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6V1K5-1 [UniParc]FASTAAdd to Basket

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    MALAHTLGFP RIGRDRELKK ALEAYWKGEL DQPGLLQVGR ELRRQHWQLQ    50
    KDAGIELLPV GDFAWYDQVL AHSLAFGVIP ERFRPADGQP TLDTLFAMAR 100
    GVAQGCCGGA HAQEMTKWFD TNYHYLVPEF TVDQAFSLSW TQLFEEVDEA 150
    LALGHAVKPV LIGPLSYLWL GKAKGGEFDR LELLERLLPV YGEIFQGLAA 200
    RGVEWVQIDE PILVLDLPQA WKNAFERAYN LIQREPLKKL VATYFGGLED 250
    NLGLAAGLPV DGLHIDLVRA PGQYPTILDR LPAYKVLSLG LVNGRNVWRC 300
    DLEKALEVLA HAHERLGERL WVAPSCSLLH SPVDLCREDQ LDEELQSWLA 350
    FAVQKCEEVA ILARALVEPE APEVRQAFEV SRRVEASRRR STRIHKREVQ 400
    ARLAAVRPQD SRRASAFAER AVQQRARLEL PAFPTTTIGS FPQTSAIRLA 450
    RQSWKQGRLS QAEYTEAMHS EIRHAVQVQE RLGLDVLVHG EAERNDMVEY 500
    FAEQLDGYAF TRFGWVQSYG SRCVKPAVIY GDLSRPRPMT VEWIRYAQSL 550
    TGKVMKGMLT GPVTMLMWSF PREDVSREVQ ARQLALALRD EVSDLEQAGI 600
    RIVQIDEAAF REGLPLRRAD WPHYLEWATE AFRLCASGVR DETQIHTHMC 650
    YSEFNDVIES IAAMDADVIT IETSRSDMEL LEAFEAFAYP NEIGPGVYDI 700
    HSPRVPAVED MVKLLSKAAE RIPAARLWVN PDCGLKTRAW AETEAALANM 750
    VAAARQLRQA NLA 763
    Length:763
    Mass (Da):86,085
    Last modified:August 21, 2007 - v1
    Checksum:i7F5BA32D334ED4FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000744 Genomic DNA. Translation: ABR84681.1.
    RefSeqiWP_012074732.1. NC_009656.1.
    YP_001346940.1. NC_009656.1.

    Genome annotation databases

    EnsemblBacteriaiABR84681; ABR84681; PSPA7_1556.
    GeneIDi5355798.
    KEGGipap:PSPA7_1556.
    PATRICi19824923. VBIPseAer80442_1498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000744 Genomic DNA. Translation: ABR84681.1 .
    RefSeqi WP_012074732.1. NC_009656.1.
    YP_001346940.1. NC_009656.1.

    3D structure databases

    ProteinModelPortali A6V1K5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381754.PSPA7_1556.

    Proteomic databases

    PRIDEi A6V1K5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR84681 ; ABR84681 ; PSPA7_1556 .
    GeneIDi 5355798.
    KEGGi pap:PSPA7_1556.
    PATRICi 19824923. VBIPseAer80442_1498.

    Phylogenomic databases

    eggNOGi COG0620.
    HOGENOMi HOG000246221.
    KOi K00549.
    OMAi FKANPAH.
    OrthoDBi EOG6FFS3G.

    Enzyme and pathway databases

    UniPathwayi UPA00051 ; UER00082 .
    BioCyci PAER381754:GHMY-1556-MONOMER.

    Family and domain databases

    HAMAPi MF_00172. Meth_synth.
    InterProi IPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view ]
    Pfami PF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Dodson R.J., Harkins D., Paulsen I.T.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PA7.

    Entry informationi

    Entry nameiMETE_PSEA7
    AccessioniPrimary (citable) accession number: A6V1K5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3