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Protein

Ribonuclease HII

Gene

rnhB

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Divalent metal cationUniRule annotation
Metal bindingi19 – 191Divalent metal cationUniRule annotation
Metal bindingi110 – 1101Divalent metal cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciPAER381754:GHMY-1497-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:PSPA7_1497
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000001582 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Ribonuclease HIIPRO_1000031179Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA6V1E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000100288.
KOiK03470.
OMAiGFASHKG.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B. 1 hit.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

A6V1E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLGLDFNLV EDLVAGVDEV GRGPLCGPVV TAAVILDPSR PILGLNDSKK
60 70 80 90 100
LSEARREALF EEIREKALAW CVARAEVEEI DRLNILHATM LAMQRAVEGL
110 120 130 140 150
SVTPRLALID GNRCPRLAVP SAPVVKGDSQ VPAIAAASIL AKVSRDREMV
160 170 180 190 200
ELDRLYPGYG MAGHKGYPTA VHLEALSRLG PTPIHRRSFA PVRELLDASV

E
Length:201
Mass (Da):21,744
Last modified:August 21, 2007 - v1
Checksum:iB22764E29DB837A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR80658.1.
RefSeqiWP_003153754.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR80658; ABR80658; PSPA7_1497.
KEGGipap:PSPA7_1497.
PATRICi19824805. VBIPseAer80442_1439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR80658.1.
RefSeqiWP_003153754.1. NC_009656.1.

3D structure databases

ProteinModelPortaliA6V1E6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR80658; ABR80658; PSPA7_1497.
KEGGipap:PSPA7_1497.
PATRICi19824805. VBIPseAer80442_1439.

Phylogenomic databases

HOGENOMiHOG000100288.
KOiK03470.
OMAiGFASHKG.

Enzyme and pathway databases

BioCyciPAER381754:GHMY-1497-MONOMER.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B. 1 hit.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNH2_PSEA7
AccessioniPrimary (citable) accession number: A6V1E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.