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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401UniRule annotation
Active sitei545 – 5451UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciPAER381754:GHMY-1451-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:PSPA7_1451
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001582: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Phosphoenolpyruvate carboxylasePRO_1000025575Add
BLAST

Proteomic databases

PRIDEiA6V1A0.

Interactioni

Protein-protein interaction databases

STRINGi381754.PSPA7_1451.

Structurei

3D structure databases

ProteinModelPortaliA6V1A0.
SMRiA6V1A0. Positions 6-878.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6V1A0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPEIDARLRE DVHQLGELLG DTIREQYGPA FLDKIERIRK GAKAARRGSA
60 70 80 90 100
EGAQQLTATL DGLEESELLP VARAFNQFLN LANIAEQYHR IRRRRPNEPE
110 120 130 140 150
PFENLALEEL LGRLKDAGHA PGQLARQLAG LEIELVLTAH PTEVARRTLI
160 170 180 190 200
QKYDAITAQL ATKDHADLLP EERSRIQRRL QRLVAEVWHT DEIRKVRPTP
210 220 230 240 250
VDEAKWGFAV IEHSLWEALP NVLRHVDEVL LRSTGERLPL SAAPLRFASW
260 270 280 290 300
MGGDRDGNPN VTAGVTREVL LLARWMAADL YLRDIDRLAA ELSMQEASPA
310 320 330 340 350
LLARVGDSAE PYRALLKQLR ERLRLTRSWT HQALAGEVPA AEGVLEHNRD
360 370 380 390 400
LVEPLQLCHE SLHACGMGVI ADGALLDCLR RAATFGLFLV RLDVRQDAGR
410 420 430 440 450
HAAALSEITE YLELGSYAEW DEKTRLEFLL EELNSRRPLL PAHYQPSAET
460 470 480 490 500
AEVLATCRAI AAAPPASLGS YVISMAGQPS DVLAVQLLLK ESGVDWPMRV
510 520 530 540 550
VPLFETLDDL DNAGPCMERL LTLPGYRSRL SGVQEVMIGY SDSAKDAGTL
560 570 580 590 600
TAAWAQYRAQ EKLVEICRHH EVELLLFHGR GGTVGRGGGP AHAAILSQPP
610 620 630 640 650
GSVAGRFRVT EQGEMIRFKF GLPDIAEQNL NLYLAAVLEA TLMPPPAPEP
660 670 680 690 700
AWRAQMDRLA KDALHAYRRV VRDDPQFVEY FRLATPEQEL GRLPLGSRPA
710 720 730 740 750
KRREGGVESL RAIPWIFAWT QTRLMLPAWL GWETALLNAI ERGEGALLGQ
760 770 780 790 800
MRERWPFFTT RIDMLEMVLA KADADIARLY DERLVPLELR PLGRRLRDLL
810 820 830 840 850
SQAVRVVLGL TGQSLLLAHA SETRESISVR NSYLDPLHLL QAELLARSRR
860 870
CRGDACGGLE QALLVTVAGI AAGLRNTG
Length:878
Mass (Da):97,731
Last modified:August 21, 2007 - v1
Checksum:iC41DD18AC146E0F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR84834.1.
RefSeqiWP_012074668.1. NC_009656.1.
YP_001346835.1. NC_009656.1.

Genome annotation databases

EnsemblBacteriaiABR84834; ABR84834; PSPA7_1451.
GeneIDi5359202.
KEGGipap:PSPA7_1451.
PATRICi19824715. VBIPseAer80442_1394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA. Translation: ABR84834.1.
RefSeqiWP_012074668.1. NC_009656.1.
YP_001346835.1. NC_009656.1.

3D structure databases

ProteinModelPortaliA6V1A0.
SMRiA6V1A0. Positions 6-878.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381754.PSPA7_1451.

Proteomic databases

PRIDEiA6V1A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR84834; ABR84834; PSPA7_1451.
GeneIDi5359202.
KEGGipap:PSPA7_1451.
PATRICi19824715. VBIPseAer80442_1394.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciPAER381754:GHMY-1451-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Dodson R.J., Harkins D., Paulsen I.T.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA7.

Entry informationi

Entry nameiCAPP_PSEA7
AccessioniPrimary (citable) accession number: A6V1A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: January 7, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.