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Protein

Dihydroxy-acid dehydratase

Gene

ilvD

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (ilvB)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-valine from pyruvate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (ilvB)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi122Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi193Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00047; UER00057
UPA00049; UER00061

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
Short name:
DADUniRule annotation
Gene namesi
Name:ilvDUniRule annotation
Ordered Locus Names:PSPA7_0446
OrganismiPseudomonas aeruginosa (strain PA7)
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000001582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000010331 – 612Dihydroxy-acid dehydrataseAdd BLAST612

Proteomic databases

PRIDEiA6UYF6

Structurei

3D structure databases

SMRiA6UYF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000173155
KOiK01687
OMAiIPGHVHL

Family and domain databases

HAMAPiMF_00012 IlvD, 1 hit
InterProiView protein in InterPro
IPR004404 DihydroxyA_deHydtase
IPR000581 DiOHA_6PGluconate_deHydtase
IPR020558 DiOHA_6PGluconate_deHydtase_CS
IPR037237 IlvD/EDD_N
PfamiView protein in Pfam
PF00920 ILVD_EDD, 1 hit
SUPFAMiSSF143975 SSF143975, 1 hit
TIGRFAMsiTIGR00110 ilvD, 1 hit
PROSITEiView protein in PROSITE
PS00886 ILVD_EDD_1, 1 hit
PS00887 ILVD_EDD_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6UYF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDYRSKTST HGRNMAGARA LWRATGMKDE DFKKPIIAIA NSFTQFVPGH
60 70 80 90 100
VHLKDLGQLV AREIEKAGGV AKEFNTIAVD DGIAMGHDGM LYSLPSREII
110 120 130 140 150
ADSVEYMVNA HCADAIVCIS NCDKITPGML MAALRLNIPV VFVSGGPMEA
160 170 180 190 200
GKTKLASHGL DLVDAMVVAA DDSCSDEKVA EYERSACPTC GSCSGMFTAN
210 220 230 240 250
SMNCLTEALG LSLPGNGSTL ATHADREQLF LRAGRLAVEL CQRYYGEGDD
260 270 280 290 300
SVLPRNIANF KAFENAMTLD IAMGGSTNTI LHLLAAAQEA EVPFDLRDID
310 320 330 340 350
RLSRKVPQLC KVAPNIQKYH MEDVHRAGGI FSILGELARG GLLHTDVATV
360 370 380 390 400
HSPSMADAIA RWDITQTRDE AVHTFFKAGP AGIPTQTAFS QNTRWPSLDD
410 420 430 440 450
DRAEGCIRSV EHAYSKEGGL AVLYGNIALD GCVVKTAGVD ESIHVFEGRA
460 470 480 490 500
KIFESQDAAV KGILGDEVKA GDIVIIRYEG PKGGPGMQEM LYPTSYLKSK
510 520 530 540 550
GLGKQCALLT DGRFSGGTSG LSIGHASPEA AAGGAIGLVQ DGDKVLIDIP
560 570 580 590 600
NRSINLLVSD EELAARRAEQ DRKGWKPAAP RARRVSTALK AYALLATSAD
610
KGAVRNKALL DG
Length:612
Mass (Da):65,259
Last modified:August 21, 2007 - v1
Checksum:iAFA6338A405F3FE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA Translation: ABR86669.1
RefSeqiWP_012073964.1, NC_009656.1

Genome annotation databases

EnsemblBacteriaiABR86669; ABR86669; PSPA7_0446
KEGGipap:PSPA7_0446

Similar proteinsi

Entry informationi

Entry nameiILVD_PSEA7
AccessioniPrimary (citable) accession number: A6UYF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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