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Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei132 – 133Important for bifunctional activityUniRule annotation2
Binding sitei135dCTPUniRule annotation1
Active sitei145Proton donor/acceptorUniRule annotation1
Binding sitei163dCTPUniRule annotation1
Binding sitei177dCTPUniRule annotation1
Binding sitei188dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi117 – 122dCTP bindingUniRule annotation6
Nucleotide bindingi143 – 145dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciMAEO419665:G1G9A-1457-MONOMER
UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:Maeo_1411
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001106 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001179801 – 201dCTP deaminase, dUMP-formingAdd BLAST201

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi419665.Maeo_1411

Structurei

3D structure databases

ProteinModelPortaliA6UWW5
SMRiA6UWW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048 Archaea
COG0717 LUCA
HOGENOMiHOG000228601
KOiK09887
OMAiGWIDAGF
OrthoDBiPOG093Z0C6C

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

A6UWW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSDNDIIK EIDSGGLVIE PFNKEFVGPC SYDITLGDEF IVYTDEVYDL
60 70 80 90 100
KKELNHNKFK IENSIMVCPL CYELDDEKIE YFKNKYGVDV VVKGGLLGTT
110 120 130 140 150
TEFVELPNDI CAQYQGRSSF GRVFLQSHQT AGWIDAGFKG KITLEIVAYD
160 170 180 190 200
KPVILYKNQR IGQLIFSKTL TPANIGYCDR KGSKYGGQNS VNASLIHKDE

I
Length:201
Mass (Da):22,662
Last modified:August 21, 2007 - v1
Checksum:i9254244E1D41CC25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA Translation: ABR56987.1
RefSeqiWP_011974119.1, NC_009635.1

Genome annotation databases

EnsemblBacteriaiABR56987; ABR56987; Maeo_1411
GeneIDi5326890
KEGGimae:Maeo_1411

Similar proteinsi

Entry informationi

Entry nameiDCDB_META3
AccessioniPrimary (citable) accession number: A6UWW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 21, 2007
Last modified: April 25, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health