Reviewed, UniProtKB/Swiss-Prot A6UWS1 (MTD_META3)

Names and origin

Protein names

Recommended name:
    F420-dependent methylenetetrahydromethanopterin dehydrogenase
      Short name=MTD
    EC=1.5.99.9
Alternative name(s):
    Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase

Gene names

Name:	mtd
Ordered Locus Names:	Maeo_1367

Organism

Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP]

Taxonomic identifier

419665 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible reduction of methenyl-H4MPT+ to methylene-H4MPT By similarity. HAMAP MF_00058
Catalytic activity	5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420. HAMAP MF_00058
Pathway	One-carbon metabolism; methanogenesis from CO(2); 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1. HAMAP MF_00058
Sequence similarities	Belongs to the MTD family.

Ontologies

Keywords
Biological process	Methanogenesis One-carbon metabolism
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro methylenetetrahydromethanopterin dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	F420-dependent methylenetetrahydromethanopterin dehydrogenase HAMAP MF_00058		PRO_1000007670

Sequences

	Sequence		Length	Mass (Da)
	A6UWS1-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 85C779579521D808	FASTA	277	29,631
	10 20 30 40 50 60 MVVKIGIIKC GNIGMSPLID LALDERADRT NIDVISIGSG AKMGPNQVVE VTTKMVEDIK 70 80 90 100 110 120 PDFIIYVGPN PAAPGPAKAR EILSASDIPS VIIGDAPGIK AKDKMAEEGL GYILIKCDPM 130 140 150 160 170 180 IGARRQFLDP VEMAMFNADV IRVLAGTGAA RVVQNAIDDI VEAIEAGNEI ELPKIVVTDA 190 200 210 220 230 240 KSVAAAEFSN PYAKAKAMAA FAMAEQVANI DVKGCFMTKE MEKYIPIVAS AHEMIRTAAK 250 260 270 LVDEARELEK ATDSVSRKPH GADGKRLNKT KLMEKPE

References

[1]

"Complete sequence of Methanococcus aeolicus Nankai-3." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000743 Genomic DNA. Translation: ABR56943.1.
RefSeq	YP_001325555.1.
3D structure databases
SMR	A6UWS1. Positions 1-277.
ModBase	Search...
Protein-protein interaction databases
STRING	A6UWS1.
Genome annotation databases
GeneID	5327444.
GenomeReviews	Gene locus Maeo_1367 in contig CP000743_GR.
KEGG	mae:Maeo_1367.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04866.
HOGENOM	HBG538567.
OMA	IVASAHE.
Family and domain databases
HAMAP	MF_00058. MTD. [Tree]
InterPro	IPR002844. Methylene_DH. [Graphical view]
Pfam	PF01993. MTD. 1 hit. [Graphical view]
PIRSF	PIRSF005627. MTD. 1 hit.
ProDom	PD017604. Methylene_DH. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

MTD_META3

Accession

Primary (citable) accession number: A6UWS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	January 19, 2010
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)