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A6UWL8 (ARGC_META3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase
Gene names
Name:argC
Ordered Locus Names:Maeo_1314
OrganismMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP]
Taxonomic identifier419665 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus ›

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP-Rule MF_00150

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP-Rule MF_00150

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionN-acetyl-gamma-glutamyl-phosphate reductase activity

Inferred from electronic annotation. Source: HAMAP

NAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344N-acetyl-gamma-glutamyl-phosphate reductase HAMAP-Rule MF_00150
PRO_1000011008

Sites

Active site1481 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6UWL8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: A53A5321C8CA1A73

FASTA34438,063
        10         20         30         40         50         60 
MVTISIIGGT GYTGSELLRI LLNHPQVEIK HITSRKMDGV NITKVHPNLK NIKNIDNLVF 

        70         80         90        100        110        120 
ENISPSNLDS DFVFCATPHG ASMKIVPELY ETGSKIIDLS GDYRFEDLSL YEKWYNLTHT 

       130        140        150        160        170        180 
GELPAVYGLP ELHRNEIKKA QLVANPGCFP TGSILALAPL VKEGIIENRI IVDSKTGVSG 

       190        200        210        220        230        240 
AGVNPSETTH YPSVNENILP YKMTTHRHSP EIEKELEKLN ISNNIKLSFT PHLAPLTRGI 

       250        260        270        280        290        300 
LSTTHSYLKN TDIDRDIIID IYNEFYKNEP FVRIFEEGAP TLTGVRGSNF CDIGGFEIDR 

       310        320        330        340 
HGRIVVVSAI DNLVKGASGQ AIHNLNLMAG FNETESLLYG GLKP

« Hide

References

[1]"Complete sequence of Methanococcus aeolicus Nankai-3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000743 Genomic DNA. Translation: ABR56890.1.
RefSeqYP_001325502.1. NC_009635.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING419665.Maeo_1314.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR56890; ABR56890; Maeo_1314.
GeneID5326715.
KEGGmae:Maeo_1314.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0002.
HOGENOMHOG000254902.
KOK00145.
OMAVCRIAVH.
ProtClustDBPRK00436.

Enzyme and pathway databases

BioCycMAEO419665:GHVZ-1359-MONOMER.
UniPathwayUPA00068; UER00108.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00150. ArgC_type1.
InterProIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. argC. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC_META3
AccessionPrimary (citable) accession number: A6UWL8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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