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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei155GTPUniRule annotation1
Binding sitei158GTPUniRule annotation1
Binding sitei201GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 41GTPUniRule annotation5
Nucleotide bindingi124 – 126GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Maeo_1288Imported
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)Imported
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001106 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi419665.Maeo_1288.

Structurei

3D structure databases

ProteinModelPortaliA6UWJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 219TubulinInterPro annotationAdd BLAST191
Domaini221 – 341Tubulin_CInterPro annotationAdd BLAST121

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiIMNQGGV.
OrthoDBiPOG093Z0942.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiView protein in InterPro
IPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
PfamiView protein in Pfam
PF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiView protein in PROSITE
PS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UWJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVNEALSS NSEEIHNKNA SRDDFGNASI IVIGCGGAGN NTIHRLTEIG
60 70 80 90 100
IEGAETMALN TDKQHLEHVN ADKKILIGST LTRGLGAGGY PEIGKKSAEL
110 120 130 140 150
AKNVLEDVLK NADLVFVTAG MGGGTGTGSA PVVAEIAKEN GAVVIGMVTY
160 170 180 190 200
PFKIERARLK KADEGLARLT EACDTVIVID NNRLVEFVPN LPLNEAFKVA
210 220 230 240 250
DEIIAQAVKG ITETISQKSL INIDYADVRS VMTDGGVAMI GVGEVDYETK
260 270 280 290 300
GDRIEKVVKD TLSCPLLDVD YAGATGAIIH ITGGTDLTIG EANAIGEGIT
310 320 330 340 350
QSMDQNANVI WGARLDPSME GCIRVMTIIT GVKSANILGK EKNNGRRIIP
360
KNTQKTKSSL NIDYIV
Length:366
Mass (Da):38,772
Last modified:August 21, 2007 - v1
Checksum:i72F16B16D9CF4407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR56864.1.
RefSeqiWP_011973996.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR56864; ABR56864; Maeo_1288.
GeneIDi5327420.
KEGGimae:Maeo_1288.

Similar proteinsi

Entry informationi

Entry nameiA6UWJ2_META3
AccessioniPrimary (citable) accession number: A6UWJ2
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 27, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported