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A6UWB3

- GSA_META3

UniProt

A6UWB3 - GSA_META3

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, Maeo_1208
Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMAEO419665:GHVZ-1233-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Maeo_1208
OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001106: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000382399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei271 – 2711N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_1208.

Structurei

3D structure databases

ProteinModelPortaliA6UWB3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiHYPSIDM.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6UWB3-1 [UniParc]FASTAAdd to Basket

« Hide

MDNTIINLNL EKSKKLFEES QKYLVKGVNS PVRYFKPFPF FVNNAKDYYL    50
VDVDGNKYID YCLAYGPAVL GHANENIANA VIEQLKHGTA YGCPTEKEIT 100
LAKEIIKRMP CAEMVRFVNS GTEATMSAIR LARGITKRNK IIKFDGAYHG 150
AHDYVLVKSG SGALTHGAPN SPGIPEDTTK HTILAPFNDK DAIVEIIKNN 200
KDEIACIIVE PVMGNVGCIP PREDYLKFLR EITEENNIIL IFDEVITGFR 250
IAKGGAQEYY GVVPDLATVG KIMGGGFPIG AIVGKKELME NFSPNGTIYQ 300
AGTFNGNPIS MTAGIETLKN LDDNFYSTTS KSAKKLSDFI GETAEKHNIP 350
HKVYTVASMF QIYFNEEEVV NYDIAKNSNT DLFMKYFYGL MENGVFIAPS 400
QFECCFTSIK HTDDVINTTM DAIEEVFKKI TR 432
Length:432
Mass (Da):48,065
Last modified:August 21, 2007 - v1
Checksum:i744966D84D1EB75D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR56785.1.
RefSeqiWP_011973917.1. NC_009635.1.
YP_001325397.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR56785; ABR56785; Maeo_1208.
GeneIDi5326788.
KEGGimae:Maeo_1208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR56785.1 .
RefSeqi WP_011973917.1. NC_009635.1.
YP_001325397.1. NC_009635.1.

3D structure databases

ProteinModelPortali A6UWB3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 419665.Maeo_1208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR56785 ; ABR56785 ; Maeo_1208 .
GeneIDi 5326788.
KEGGi mae:Maeo_1208.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi HYPSIDM.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci MAEO419665:GHVZ-1233-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nankai-3 / ATCC BAA-1280.

Entry informationi

Entry nameiGSA_META3
AccessioniPrimary (citable) accession number: A6UWB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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