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A6UW80

- A6UW80_META3

UniProt

A6UW80 - A6UW80_META3

Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation
    (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei107 – 1071UniRule annotation

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. isomerase activity Source: UniProtKB-KW
    3. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseImported, OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciMAEO419665:GHVZ-1200-MONOMER.
    UniPathwayiUPA00047; UER00056.
    UPA00049; UER00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
    Alternative name(s):
    Acetohydroxy-acid isomeroreductaseUniRule annotation
    Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
    Gene namesi
    Name:ilvCUniRule annotation
    Ordered Locus Names:Maeo_1175Imported
    OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)Imported
    Taxonomic identifieri419665 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000001106: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi419665.Maeo_1175.

    Structurei

    3D structure databases

    ProteinModelPortaliA6UW80.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketol-acid reductoisomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0059.
    HOGENOMiHOG000016230.
    KOiK00053.
    OMAiWIKEYER.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    HAMAPiMF_00435. IlvC.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view]
    PANTHERiPTHR21371. PTHR21371. 1 hit.
    PfamiPF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00465. ilvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6UW80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVYYEEDAN YDAVKDKTIA VIGYGSQGMA QSCNMKDSGL NVIVGLRPNG    50
    ASWEKAKADG HTVMSVEEAA EKADIIHILI PDEVQKDVYN NQIKQHLTEG 100
    KTLSFSHGYN VHFKYIDPIK GVNVIMVAPK SPGAMVRRTY TEGFGVPGLV 150
    CVERDETGDA LDIALGMAKA EGLTKAGVIK TTFKEETETD LFGEQAVLCG 200
    GVTELIKAGF DTLVEAGYSP EMAYFETCNE LKLIVDLIYQ KGLAGMWNDV 250
    SNTAEYGGFV TRERVINEES RKAMREILKE IQNGKFARDW ALENVSGIPH 300
    LNAMRRLEDE SLLETTGKKL RKMCGLQKD 329
    Length:329
    Mass (Da):36,348
    Last modified:August 21, 2007 - v1
    Checksum:i8D72B89581B32026
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000743 Genomic DNA. Translation: ABR56752.1.
    RefSeqiYP_001325364.1. NC_009635.1.

    Genome annotation databases

    EnsemblBacteriaiABR56752; ABR56752; Maeo_1175.
    GeneIDi5326459.
    KEGGimae:Maeo_1175.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000743 Genomic DNA. Translation: ABR56752.1 .
    RefSeqi YP_001325364.1. NC_009635.1.

    3D structure databases

    ProteinModelPortali A6UW80.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419665.Maeo_1175.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR56752 ; ABR56752 ; Maeo_1175 .
    GeneIDi 5326459.
    KEGGi mae:Maeo_1175.

    Phylogenomic databases

    eggNOGi COG0059.
    HOGENOMi HOG000016230.
    KOi K00053.
    OMAi WIKEYER.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00056 .
    UPA00049 ; UER00060 .
    BioCyci MAEO419665:GHVZ-1200-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    HAMAPi MF_00435. IlvC.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view ]
    PANTHERi PTHR21371. PTHR21371. 1 hit.
    Pfami PF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00465. ilvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nankai-3 / ATCC BAA-1280Imported.

    Entry informationi

    Entry nameiA6UW80_META3
    AccessioniPrimary (citable) accession number: A6UW80
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3