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A6UW80 (A6UW80_META3) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase HAMAP-Rule MF_00435

EC=1.1.1.86 HAMAP-Rule MF_00435
Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP-Rule MF_00435
Alpha-keto-beta-hydroxylacyl reductoisomerase HAMAP-Rule MF_00435
Gene names
Name:ilvC HAMAP-Rule MF_00435
Ordered Locus Names:Maeo_1175 EMBL ABR56752.1
OrganismMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP] EMBL ABR56752.1
Taxonomic identifier419665 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family. HAMAP-Rule MF_00435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1071 By similarity HAMAP-Rule MF_00435

Sequences

Sequence LengthMass (Da)Tools
A6UW80 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 8D72B89581B32026

FASTA32936,348
        10         20         30         40         50         60 
MKVYYEEDAN YDAVKDKTIA VIGYGSQGMA QSCNMKDSGL NVIVGLRPNG ASWEKAKADG 

        70         80         90        100        110        120 
HTVMSVEEAA EKADIIHILI PDEVQKDVYN NQIKQHLTEG KTLSFSHGYN VHFKYIDPIK 

       130        140        150        160        170        180 
GVNVIMVAPK SPGAMVRRTY TEGFGVPGLV CVERDETGDA LDIALGMAKA EGLTKAGVIK 

       190        200        210        220        230        240 
TTFKEETETD LFGEQAVLCG GVTELIKAGF DTLVEAGYSP EMAYFETCNE LKLIVDLIYQ 

       250        260        270        280        290        300 
KGLAGMWNDV SNTAEYGGFV TRERVINEES RKAMREILKE IQNGKFARDW ALENVSGIPH 

       310        320 
LNAMRRLEDE SLLETTGKKL RKMCGLQKD 

« Hide

References

[1]"Complete sequence of Methanococcus aeolicus Nankai-3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000743 Genomic DNA. Translation: ABR56752.1.
RefSeqYP_001325364.1. NC_009635.1.

3D structure databases

ProteinModelPortalA6UW80.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING419665.Maeo_1175.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR56752; ABR56752; Maeo_1175.
GeneID5326459.
KEGGmae:Maeo_1175.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHOG000016230.
KOK00053.
OMAWIKEYER.

Enzyme and pathway databases

BioCycMAEO419665:GHVZ-1200-MONOMER.
UniPathwayUPA00047; UER00056.
UPA00049; UER00060.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
HAMAPMF_00435. IlvC.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERPTHR21371. PTHR21371. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6UW80_META3
AccessionPrimary (citable) accession number: A6UW80
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)