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A6UW80

- A6UW80_META3

UniProt

A6UW80 - A6UW80_META3

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Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071UniRule annotation

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. isomerase activity Source: UniProtKB-KW
  3. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported, OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciMAEO419665:GHVZ-1200-MONOMER.
UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
Alternative name(s):
Acetohydroxy-acid isomeroreductaseUniRule annotation
Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
Gene namesi
Name:ilvCUniRule annotation
Ordered Locus Names:Maeo_1175Imported
OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)Imported
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001106: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_1175.

Structurei

3D structure databases

ProteinModelPortaliA6UW80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketol-acid reductoisomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0059.
HOGENOMiHOG000016230.
KOiK00053.
OMAiWIKEYER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UW80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVYYEEDAN YDAVKDKTIA VIGYGSQGMA QSCNMKDSGL NVIVGLRPNG
60 70 80 90 100
ASWEKAKADG HTVMSVEEAA EKADIIHILI PDEVQKDVYN NQIKQHLTEG
110 120 130 140 150
KTLSFSHGYN VHFKYIDPIK GVNVIMVAPK SPGAMVRRTY TEGFGVPGLV
160 170 180 190 200
CVERDETGDA LDIALGMAKA EGLTKAGVIK TTFKEETETD LFGEQAVLCG
210 220 230 240 250
GVTELIKAGF DTLVEAGYSP EMAYFETCNE LKLIVDLIYQ KGLAGMWNDV
260 270 280 290 300
SNTAEYGGFV TRERVINEES RKAMREILKE IQNGKFARDW ALENVSGIPH
310 320
LNAMRRLEDE SLLETTGKKL RKMCGLQKD
Length:329
Mass (Da):36,348
Last modified:August 21, 2007 - v1
Checksum:i8D72B89581B32026
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR56752.1.
RefSeqiYP_001325364.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR56752; ABR56752; Maeo_1175.
GeneIDi5326459.
KEGGimae:Maeo_1175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR56752.1 .
RefSeqi YP_001325364.1. NC_009635.1.

3D structure databases

ProteinModelPortali A6UW80.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419665.Maeo_1175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR56752 ; ABR56752 ; Maeo_1175 .
GeneIDi 5326459.
KEGGi mae:Maeo_1175.

Phylogenomic databases

eggNOGi COG0059.
HOGENOMi HOG000016230.
KOi K00053.
OMAi WIKEYER.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00056 .
UPA00049 ; UER00060 .
BioCyci MAEO419665:GHVZ-1200-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
HAMAPi MF_00435. IlvC.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view ]
PANTHERi PTHR21371. PTHR21371. 1 hit.
Pfami PF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00465. ilvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nankai-3 / ATCC BAA-1280Imported.

Entry informationi

Entry nameiA6UW80_META3
AccessioniPrimary (citable) accession number: A6UW80
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3