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A6UW60

- TF2B_META3

UniProt

A6UW60 - TF2B_META3

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Protein

Transcription initiation factor IIB

Gene
tfb, Maeo_1155
Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Zinc By similarity
Metal bindingi41 – 411Zinc By similarity
Metal bindingi57 – 571Zinc By similarity
Metal bindingi60 – 601Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 6532TFIIB-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMAEO419665:GHVZ-1178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIB
Short name:
TFIIB
Gene namesi
Name:tfb
Ordered Locus Names:Maeo_1155
OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001106: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Transcription initiation factor IIBUniRule annotationPRO_1000080106Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_1155.

Structurei

3D structure databases

ProteinModelPortaliA6UW60.
SMRiA6UW60. Positions 138-334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati151 – 234841UniRule annotationAdd
BLAST
Repeati245 – 326822UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6UW60-1 [UniParc]FASTAAdd to Basket

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MDIKLISKKK NIEERKQLLS ELHASKSVIV EKDEELVCPM CDSKNIIKDY    50
EKAEIVCEDC GCVLQDNLFD VGPEWRAFDH EQRVKRSRVG APMTYTIHDK 100
GLSTVIDWRN KDSYGKDISA DKRAQLYRLR KWQRRIRVSD ASERNLAFAL 150
SELDRIASKL GLPRNVRENA AVLYRGAVEK GLIRGRSIEG VAAAALYAAC 200
RRCKVPRTLD EIAEMSRVDR KEIGRTYRFI SRELKIRLAP TSPIDYVPRF 250
ASELKLPGEV ESKAISILQK AGDKGLTSGR GPTGVAAAAI YIASVLHGTR 300
KTQREVADVA GVTEVTIRNR YKELTEHLDI DVTL 334
Length:334
Mass (Da):37,654
Last modified:August 21, 2007 - v1
Checksum:iA1609C576A679B6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR56732.1.
RefSeqiYP_001325344.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR56732; ABR56732; Maeo_1155.
GeneIDi5327478.
KEGGimae:Maeo_1155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR56732.1 .
RefSeqi YP_001325344.1. NC_009635.1.

3D structure databases

ProteinModelPortali A6UW60.
SMRi A6UW60. Positions 138-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419665.Maeo_1155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR56732 ; ABR56732 ; Maeo_1155 .
GeneIDi 5327478.
KEGGi mae:Maeo_1155.

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108633.
KOi K03124.
OMAi WRAFDHD.

Enzyme and pathway databases

BioCyci MAEO419665:GHVZ-1178-MONOMER.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
HAMAPi MF_00383. TF2B_arch.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nankai-3 / ATCC BAA-1280.

Entry informationi

Entry nameiTF2B_META3
AccessioniPrimary (citable) accession number: A6UW60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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