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A6UW60 (TF2B_META3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription initiation factor IIB

Short name=TFIIB
Gene names
Name:tfb
Ordered Locus Names:Maeo_1155
OrganismMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP]
Taxonomic identifier419665 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity. HAMAP-Rule MF_00383

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00383

Sequence similarities

Belongs to the TFIIB family.

Contains 1 TFIIB-type zinc finger.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Transcription initiation factor IIB HAMAP-Rule MF_00383
PRO_1000080106

Regions

Repeat151 – 234841 HAMAP-Rule MF_00383
Repeat245 – 326822 HAMAP-Rule MF_00383
Zinc finger34 – 6532TFIIB-type HAMAP-Rule MF_00383

Sites

Metal binding381Zinc By similarity
Metal binding411Zinc By similarity
Metal binding571Zinc By similarity
Metal binding601Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A6UW60 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: A1609C576A679B6E

FASTA33437,654
        10         20         30         40         50         60 
MDIKLISKKK NIEERKQLLS ELHASKSVIV EKDEELVCPM CDSKNIIKDY EKAEIVCEDC 

        70         80         90        100        110        120 
GCVLQDNLFD VGPEWRAFDH EQRVKRSRVG APMTYTIHDK GLSTVIDWRN KDSYGKDISA 

       130        140        150        160        170        180 
DKRAQLYRLR KWQRRIRVSD ASERNLAFAL SELDRIASKL GLPRNVRENA AVLYRGAVEK 

       190        200        210        220        230        240 
GLIRGRSIEG VAAAALYAAC RRCKVPRTLD EIAEMSRVDR KEIGRTYRFI SRELKIRLAP 

       250        260        270        280        290        300 
TSPIDYVPRF ASELKLPGEV ESKAISILQK AGDKGLTSGR GPTGVAAAAI YIASVLHGTR 

       310        320        330 
KTQREVADVA GVTEVTIRNR YKELTEHLDI DVTL 

« Hide

References

[1]"Complete sequence of Methanococcus aeolicus Nankai-3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000743 Genomic DNA. Translation: ABR56732.1.
RefSeqYP_001325344.1. NC_009635.1.

3D structure databases

ProteinModelPortalA6UW60.
SMRA6UW60. Positions 138-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING419665.Maeo_1155.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR56732; ABR56732; Maeo_1155.
GeneID5327478.
KEGGmae:Maeo_1155.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1405.
HOGENOMHOG000108633.
KOK03124.
OMAWRAFDHD.

Enzyme and pathway databases

BioCycMAEO419665:GHVZ-1178-MONOMER.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
HAMAPMF_00383. TF2B_arch.
InterProIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERPTHR11618. PTHR11618. 1 hit.
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSPR00685. TIFACTORIIB.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTF2B_META3
AccessionPrimary (citable) accession number: A6UW60
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families