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Protein

Lactaldehyde dehydrogenase

Gene

Maeo_1030

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.By similarity

Catalytic activityi

(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH.

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei240PROSITE-ProRule annotation1
Active sitei274PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 225NADBy similarity6

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactaldehyde dehydrogenase (EC:1.2.1.22)
Gene namesi
Ordered Locus Names:Maeo_1030
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001106 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425891 – 465Lactaldehyde dehydrogenaseAdd BLAST465

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi419665.Maeo_1030.

Structurei

3D structure databases

ProteinModelPortaliA6UVT6.
SMRiA6UVT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiarCOG01252. Archaea.
COG1012. LUCA.
HOGENOMiHOG000271509.
KOiK19266.
OMAiYEFFTEV.
OrthoDBiPOG093Z01H3.

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiView protein in PROSITE
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UVT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFINGEWINR KDIEVKNPYN NEIIGYIPSL SRNETKEAIK IAEEHKSTMK
60 70 80 90 100
NLSPTIRYNI LMKIASELSK NKRELAKLIT IDVGKPIKQS IIEVDRTITT
110 120 130 140 150
FKFSAFYSRE LRGETIPFDD GMVITKREPV GLVGAITPFN FPLNLFAHKI
160 170 180 190 200
APAIAMGNSI VAHPSSKAPM ITIELTKIIE KVLKSKKIPL GVFNLLTGEG
210 220 230 240 250
HIVGDEIVKN NKINKLSFTG SVEVGESITK KAGFKKITLE LGGNNPMIIL
260 270 280 290 300
KDANINKAVE SCMSGKFLNS GQVCISVGRV LIEQEVADEF INKIVEKVKK
310 320 330 340 350
LKIGNPLDED TNISSLISLD SAERVEKLIN KSIGQGGKLI CGGKRENSII
360 370 380 390 400
YPTILEITAD NILANIEIFA PVLPIIRVND MNEALNQANN SNYGLHSGVF
410 420 430 440 450
TQDINKALYF ADNLEYGGVL INNSPTFRID NMPFGGIKHS GLGREGIKYA
460
IDEMSEIKTI IVNTK
Length:465
Mass (Da):51,327
Last modified:August 21, 2007 - v1
Checksum:i921D851D658893FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR56608.1.
RefSeqiWP_011973740.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR56608; ABR56608; Maeo_1030.
GeneIDi5327289.
KEGGimae:Maeo_1030.

Similar proteinsi

Entry informationi

Entry nameiLADH_META3
AccessioniPrimary (citable) accession number: A6UVT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 21, 2007
Last modified: June 7, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families