A6UVI3 (A6UVI3_META3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthase HAMAP MF_00180
Short name=DHBP synthase HAMAP MF_00180
EC=4.1.99.12 HAMAP MF_00180

Gene names

Name:	ribB HAMAP MF_00180
Ordered Locus Names:	Maeo_0924

Organism

Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP] EMBL ABR56505.1

Taxonomic identifier

419665 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity. HAMAP MF_00180
Catalytic activity	D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate. HAMAP MF_00180
Cofactor	Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity. HAMAP MF_00180
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1. HAMAP MF_00180
Subunit structure	Homodimer By similarity. HAMAP MF_00180
Sequence similarities	Belongs to the DHBP synthase family. HAMAP MF_00180

Ontologies

Keywords
Biological process	Riboflavin biosynthesis HAMAP MF_00180
Ligand	Magnesium HAMAP MF_00180 Manganese HAMAP MF_00180 Metal-binding HAMAP MF_00180
Molecular function	Lyase HAMAP MF_00180
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3,4-dihydroxy-2-butanone-4-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	28 – 29	2	Substrate binding By similarity HAMAP MF_00180
	Region	164 – 168	5	Substrate binding By similarity HAMAP MF_00180
Sites
	Metal binding	29	1	Magnesium or manganese 1 By similarity HAMAP MF_00180
	Metal binding	29	1	Magnesium or manganese 2 By similarity HAMAP MF_00180
	Metal binding	167	1	Magnesium or manganese 2 By similarity HAMAP MF_00180
	Binding site	33	1	Substrate By similarity HAMAP MF_00180
	Binding site	188	1	Substrate By similarity HAMAP MF_00180
	Site	150	1	Essential for catalytic activity By similarity HAMAP MF_00180
	Site	188	1	Essential for catalytic activity By similarity HAMAP MF_00180

Sequences

	Sequence		Length	Mass (Da)
	A6UVI3 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: B12EC88BCF7E0BF6	FASTA	229	25,753
	10 20 30 40 50 60 MSENAKIEKA INDLKNGKMI LIYDSDDREG EADMVVASEF ITPEHIRTMR KDGGGLICTA 70 80 90 100 110 120 IHPKYCEAVG IPFMIDVFDC ANEKFPILKE LYPNDIPYDE KSSFSITVNH RSTFTGITDN 130 140 150 160 170 180 DRALTIKKLA ELLKEKRYND FGKEFRAPGH VVLLRASEGL LKNREGHTEM TVALAELAGL 190 200 210 220 TPITTICEMM GDDGKAMSRA ETEKYAEEHG LAHLNGEELI NYYMDKINK

References

[1]

"Complete sequence of Methanococcus aeolicus Nankai-3." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000743 Genomic DNA. Translation: ABR56505.1.
RefSeq	YP_001325117.1. NC_009635.1.
3D structure databases
ProteinModelPortal	A6UVI3.
SMR	A6UVI3. Positions 7-223.
ModBase	Search...
Protein-protein interaction databases
STRING	A6UVI3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5326503.
GenomeReviews	Gene locus Maeo_0924 in contig CP000743_GR.
KEGG	mae:Maeo_0924.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05755.
HOGENOM	HBG735778.
OMA	GDMIFAA.
ProtClustDB	CLSK876051.
Family and domain databases
HAMAP	MF_00180. RibB. [Tree]
InterPro	IPR017945. DHBP_synth_RibB-like_a/b_dom. IPR000422. DHBP_synthase_RibB. [Graphical view]
Gene3D	G3DSA:3.90.870.10. DHBP_synth_RibB-like_a/b_dom. 1 hit.
KO	K02858.
Pfam	PF00926. DHBP_synthase. 1 hit. [Graphical view]
SUPFAM	SSF55821. DHBP_synth_RibB-like_a/b_dom. 1 hit.
TIGRFAMs	TIGR00506. RibB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6UVI3_META3

Accession

Primary (citable) accession number: A6UVI3

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)