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A6UVC9

- GUAAA_META3

UniProt

A6UVC9 - GUAAA_META3

Protein

GMP synthase [glutamine-hydrolyzing] subunit A

Gene

guaAA

Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of GMP from XMP.UniRule annotation

    Catalytic activityi

    ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761NucleophileUniRule annotation
    Active sitei163 – 1631UniRule annotation
    Active sitei165 – 1651UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-HAMAP
    2. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMAEO419665:GHVZ-880-MONOMER.
    UniPathwayiUPA00189; UER00296.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GMP synthase [glutamine-hydrolyzing] subunit AUniRule annotation (EC:6.3.5.2UniRule annotation)
    Alternative name(s):
    Glutamine amidotransferaseUniRule annotation
    Gene namesi
    Name:guaAAUniRule annotation
    Ordered Locus Names:Maeo_0869
    OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
    Taxonomic identifieri419665 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000001106: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188GMP synthase [glutamine-hydrolyzing] subunit APRO_0000316093Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).UniRule annotation

    Protein-protein interaction databases

    STRINGi419665.Maeo_0869.

    Structurei

    3D structure databases

    ProteinModelPortaliA6UVC9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 188188Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0518.
    HOGENOMiHOG000025031.
    KOiK01951.
    OMAiNNGGQYV.

    Family and domain databases

    Gene3Di3.40.50.880. 1 hit.
    HAMAPiMF_01510. GMP_synthase_A.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR004739. GMP_synth_N.
    IPR023686. GMP_synthase_A.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR00888. guaA_Nterm. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6UVC9-1 [UniParc]FASTAAdd to Basket

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    MIVILNNGGQ YVHRIHRSLR YLKIPSKIIP NSTPLAEIEE NKEIKGIILS    50
    GGPDIEKASN CLDIALNSKL PILGICLGHQ IIAKAYGGEI GRAESEEYAH 100
    SKIFVKEEND LFKNVPKEFT AWASHKDEVV GAPLNFEILA YSNICEVEAM 150
    KHKEKPIYGV QFHPEVSHTE NGAEILKNFC KVCGLLGE 188
    Length:188
    Mass (Da):20,877
    Last modified:August 21, 2007 - v1
    Checksum:i2540A7E6E98378CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000743 Genomic DNA. Translation: ABR56451.1.
    RefSeqiWP_011973583.1. NC_009635.1.
    YP_001325063.1. NC_009635.1.

    Genome annotation databases

    EnsemblBacteriaiABR56451; ABR56451; Maeo_0869.
    GeneIDi5326839.
    KEGGimae:Maeo_0869.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000743 Genomic DNA. Translation: ABR56451.1 .
    RefSeqi WP_011973583.1. NC_009635.1.
    YP_001325063.1. NC_009635.1.

    3D structure databases

    ProteinModelPortali A6UVC9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419665.Maeo_0869.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR56451 ; ABR56451 ; Maeo_0869 .
    GeneIDi 5326839.
    KEGGi mae:Maeo_0869.

    Phylogenomic databases

    eggNOGi COG0518.
    HOGENOMi HOG000025031.
    KOi K01951.
    OMAi NNGGQYV.

    Enzyme and pathway databases

    UniPathwayi UPA00189 ; UER00296 .
    BioCyci MAEO419665:GHVZ-880-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.880. 1 hit.
    HAMAPi MF_01510. GMP_synthase_A.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR004739. GMP_synth_N.
    IPR023686. GMP_synthase_A.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR00888. guaA_Nterm. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nankai-3 / ATCC BAA-1280.

    Entry informationi

    Entry nameiGUAAA_META3
    AccessioniPrimary (citable) accession number: A6UVC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3