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Protein

GMP synthase [glutamine-hydrolyzing] subunit A

Gene

guaAA

Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761NucleophileUniRule annotation
Active sitei163 – 1631UniRule annotation
Active sitei165 – 1651UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-HAMAP
  2. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAEO419665:GHVZ-880-MONOMER.
UniPathwayiUPA00189; UER00296.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] subunit AUniRule annotation (EC:6.3.5.2UniRule annotation)
Alternative name(s):
Glutamine amidotransferaseUniRule annotation
Gene namesi
Name:guaAAUniRule annotation
Ordered Locus Names:Maeo_0869
OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001106: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188GMP synthase [glutamine-hydrolyzing] subunit APRO_0000316093Add
BLAST

Interactioni

Subunit structurei

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).UniRule annotation

Protein-protein interaction databases

STRINGi419665.Maeo_0869.

Structurei

3D structure databases

ProteinModelPortaliA6UVC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 188188Glutamine amidotransferase type-1UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0518.
HOGENOMiHOG000025031.
KOiK01951.
OMAiNNGGQYV.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_01510. GMP_synthase_A.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR004739. GMP_synth_N.
IPR023686. GMP_synthase_A.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6UVC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVILNNGGQ YVHRIHRSLR YLKIPSKIIP NSTPLAEIEE NKEIKGIILS
60 70 80 90 100
GGPDIEKASN CLDIALNSKL PILGICLGHQ IIAKAYGGEI GRAESEEYAH
110 120 130 140 150
SKIFVKEEND LFKNVPKEFT AWASHKDEVV GAPLNFEILA YSNICEVEAM
160 170 180
KHKEKPIYGV QFHPEVSHTE NGAEILKNFC KVCGLLGE
Length:188
Mass (Da):20,877
Last modified:August 21, 2007 - v1
Checksum:i2540A7E6E98378CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR56451.1.
RefSeqiYP_001325063.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR56451; ABR56451; Maeo_0869.
GeneIDi5326839.
KEGGimae:Maeo_0869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR56451.1.
RefSeqiYP_001325063.1. NC_009635.1.

3D structure databases

ProteinModelPortaliA6UVC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419665.Maeo_0869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR56451; ABR56451; Maeo_0869.
GeneIDi5326839.
KEGGimae:Maeo_0869.

Phylogenomic databases

eggNOGiCOG0518.
HOGENOMiHOG000025031.
KOiK01951.
OMAiNNGGQYV.

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.
BioCyciMAEO419665:GHVZ-880-MONOMER.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_01510. GMP_synthase_A.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR004739. GMP_synth_N.
IPR023686. GMP_synthase_A.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nankai-3 / ATCC BAA-1280.

Entry informationi

Entry nameiGUAAA_META3
AccessioniPrimary (citable) accession number: A6UVC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: March 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.