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A6UVC9

- GUAAA_META3

UniProt

A6UVC9 - GUAAA_META3

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Protein
GMP synthase [glutamine-hydrolyzing] subunit A
Gene
guaAA, Maeo_0869
Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP By similarity.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Nucleophile By similarity
Active sitei163 – 1631 By similarity
Active sitei165 – 1651 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAEO419665:GHVZ-880-MONOMER.
UniPathwayiUPA00189; UER00296.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] subunit A (EC:6.3.5.2)
Alternative name(s):
Glutamine amidotransferase
Gene namesi
Name:guaAA
Ordered Locus Names:Maeo_0869
OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001106: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188GMP synthase [glutamine-hydrolyzing] subunit AUniRule annotation
PRO_0000316093Add
BLAST

Interactioni

Subunit structurei

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Reviewed prediction.

Protein-protein interaction databases

STRINGi419665.Maeo_0869.

Structurei

3D structure databases

ProteinModelPortaliA6UVC9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 188188Glutamine amidotransferase type-1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0518.
HOGENOMiHOG000025031.
KOiK01951.
OMAiNNGGQYV.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_01510. GMP_synthase_A.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR004739. GMP_synth_N.
IPR023686. GMP_synthase_A.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6UVC9-1 [UniParc]FASTAAdd to Basket

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MIVILNNGGQ YVHRIHRSLR YLKIPSKIIP NSTPLAEIEE NKEIKGIILS    50
GGPDIEKASN CLDIALNSKL PILGICLGHQ IIAKAYGGEI GRAESEEYAH 100
SKIFVKEEND LFKNVPKEFT AWASHKDEVV GAPLNFEILA YSNICEVEAM 150
KHKEKPIYGV QFHPEVSHTE NGAEILKNFC KVCGLLGE 188
Length:188
Mass (Da):20,877
Last modified:August 21, 2007 - v1
Checksum:i2540A7E6E98378CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR56451.1.
RefSeqiWP_011973583.1. NC_009635.1.
YP_001325063.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR56451; ABR56451; Maeo_0869.
GeneIDi5326839.
KEGGimae:Maeo_0869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR56451.1 .
RefSeqi WP_011973583.1. NC_009635.1.
YP_001325063.1. NC_009635.1.

3D structure databases

ProteinModelPortali A6UVC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419665.Maeo_0869.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR56451 ; ABR56451 ; Maeo_0869 .
GeneIDi 5326839.
KEGGi mae:Maeo_0869.

Phylogenomic databases

eggNOGi COG0518.
HOGENOMi HOG000025031.
KOi K01951.
OMAi NNGGQYV.

Enzyme and pathway databases

UniPathwayi UPA00189 ; UER00296 .
BioCyci MAEO419665:GHVZ-880-MONOMER.

Family and domain databases

Gene3Di 3.40.50.880. 1 hit.
HAMAPi MF_01510. GMP_synthase_A.
InterProi IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR004739. GMP_synth_N.
IPR023686. GMP_synthase_A.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00888. guaA_Nterm. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nankai-3 / ATCC BAA-1280.

Entry informationi

Entry nameiGUAAA_META3
AccessioniPrimary (citable) accession number: A6UVC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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