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Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable L-aspartate dehydrogenase (nadX)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123NAD; via amide nitrogenUniRule annotation1
Binding sitei189NADUniRule annotation1
Active sitei217UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

BioCyciMAEO419665:G1G9A-858-MONOMER
UniPathwayiUPA00253; UER00456

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:Maeo_0848
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000673021 – 266Probable L-aspartate dehydrogenaseAdd BLAST266

Proteomic databases

PRIDEiA6UVA8

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_0848

Structurei

3D structure databases

ProteinModelPortaliA6UVA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00254 Archaea
COG1712 LUCA
HOGENOMiHOG000206326
KOiK06989
OMAiMIMSVGA
OrthoDBiPOG093Z0FE7

Family and domain databases

HAMAPiMF_01265 NadX, 1 hit
InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR002811 Asp_DH
IPR022487 Asp_DH_arc
IPR020626 Asp_DH_prok
IPR011182 L-Asp_DH
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01958 DUF108, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF005227 Asp_dh_NAD_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03855 NAD_NadX, 1 hit

Sequencei

Sequence statusi: Complete.

A6UVA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIGIIGCG TIATMIAKAI NYKKINGTIV ALYDKHNDKS QDLNKLTNAK
60 70 80 90 100
ICDSIDKLVK EELDIVIECA SIKSVEEVAT KSLNHKKNVV IMSVGALADK
110 120 130 140 150
NLFSKLYKIA NDNEKKIFVP SGAIAGVDAI KTASIGRIDE VSLITTKPVY
160 170 180 190 200
GLEDALKNKG IDTTNISEPT VVFEGTVFDA IKEFPQNINV SVVLSIASKI
210 220 230 240 250
PAKVKIVADP SATSNKHEII VKGSIGTIKT VVENNPCKDN PKTSALAAYS
260
VIRLLKDLSE PIIVGT
Length:266
Mass (Da):28,532
Last modified:August 21, 2007 - v1
Checksum:i27EA3020815A7AAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA Translation: ABR56430.1
RefSeqiWP_011973562.1, NC_009635.1

Genome annotation databases

EnsemblBacteriaiABR56430; ABR56430; Maeo_0848
GeneIDi5326330
KEGGimae:Maeo_0848

Similar proteinsi

Entry informationi

Entry nameiASPD_META3
AccessioniPrimary (citable) accession number: A6UVA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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