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Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable L-aspartate dehydrogenase (nadX)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123NAD; via amide nitrogenUniRule annotation1
Binding sitei189NADUniRule annotation1
Active sitei217UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:Maeo_0848
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001106 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000673021 – 266Probable L-aspartate dehydrogenaseAdd BLAST266

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_0848.

Structurei

3D structure databases

ProteinModelPortaliA6UVA8.
SMRiA6UVA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00254. Archaea.
COG1712. LUCA.
HOGENOMiHOG000206326.
KOiK06989.
OMAiMIMSVGA.
OrthoDBiPOG093Z0FE7.

Family and domain databases

HAMAPiMF_01265. NadX. 1 hit.
InterProiView protein in InterPro
IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR022487. Asp_DH_arc.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03855. NAD_NadX. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UVA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIGIIGCG TIATMIAKAI NYKKINGTIV ALYDKHNDKS QDLNKLTNAK
60 70 80 90 100
ICDSIDKLVK EELDIVIECA SIKSVEEVAT KSLNHKKNVV IMSVGALADK
110 120 130 140 150
NLFSKLYKIA NDNEKKIFVP SGAIAGVDAI KTASIGRIDE VSLITTKPVY
160 170 180 190 200
GLEDALKNKG IDTTNISEPT VVFEGTVFDA IKEFPQNINV SVVLSIASKI
210 220 230 240 250
PAKVKIVADP SATSNKHEII VKGSIGTIKT VVENNPCKDN PKTSALAAYS
260
VIRLLKDLSE PIIVGT
Length:266
Mass (Da):28,532
Last modified:August 21, 2007 - v1
Checksum:i27EA3020815A7AAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR56430.1.
RefSeqiWP_011973562.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR56430; ABR56430; Maeo_0848.
GeneIDi5326330.
KEGGimae:Maeo_0848.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiASPD_META3
AccessioniPrimary (citable) accession number: A6UVA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 10, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families