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A6UVA8

- ASPD_META3

UniProt

A6UVA8 - ASPD_META3

Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

    Catalytic activityi

    L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei123 – 1231NAD; via amide nitrogenUniRule annotation
    Binding sitei189 – 1891NADUniRule annotation
    Active sitei217 – 2171UniRule annotation

    GO - Molecular functioni

    1. aspartate dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADP binding Source: UniProtKB-HAMAP
    4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP
    2. NADP catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciMAEO419665:GHVZ-859-MONOMER.
    UniPathwayiUPA00253; UER00456.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
    Gene namesi
    Name:nadXUniRule annotation
    Ordered Locus Names:Maeo_0848
    OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
    Taxonomic identifieri419665 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000001106: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Probable L-aspartate dehydrogenasePRO_1000067302Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi419665.Maeo_0848.

    Structurei

    3D structure databases

    ProteinModelPortaliA6UVA8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-aspartate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1712.
    HOGENOMiHOG000206326.
    KOiK06989.
    OMAiFHAKIEN.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01265. NadX.
    InterProiIPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR022487. Asp_DH_arc.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.
    TIGRFAMsiTIGR03855. NAD_NadX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6UVA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKIGIIGCG TIATMIAKAI NYKKINGTIV ALYDKHNDKS QDLNKLTNAK    50
    ICDSIDKLVK EELDIVIECA SIKSVEEVAT KSLNHKKNVV IMSVGALADK 100
    NLFSKLYKIA NDNEKKIFVP SGAIAGVDAI KTASIGRIDE VSLITTKPVY 150
    GLEDALKNKG IDTTNISEPT VVFEGTVFDA IKEFPQNINV SVVLSIASKI 200
    PAKVKIVADP SATSNKHEII VKGSIGTIKT VVENNPCKDN PKTSALAAYS 250
    VIRLLKDLSE PIIVGT 266
    Length:266
    Mass (Da):28,532
    Last modified:August 21, 2007 - v1
    Checksum:i27EA3020815A7AAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000743 Genomic DNA. Translation: ABR56430.1.
    RefSeqiWP_011973562.1. NC_009635.1.
    YP_001325042.1. NC_009635.1.

    Genome annotation databases

    EnsemblBacteriaiABR56430; ABR56430; Maeo_0848.
    GeneIDi5326330.
    KEGGimae:Maeo_0848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000743 Genomic DNA. Translation: ABR56430.1 .
    RefSeqi WP_011973562.1. NC_009635.1.
    YP_001325042.1. NC_009635.1.

    3D structure databases

    ProteinModelPortali A6UVA8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419665.Maeo_0848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR56430 ; ABR56430 ; Maeo_0848 .
    GeneIDi 5326330.
    KEGGi mae:Maeo_0848.

    Phylogenomic databases

    eggNOGi COG1712.
    HOGENOMi HOG000206326.
    KOi K06989.
    OMAi FHAKIEN.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00456 .
    BioCyci MAEO419665:GHVZ-859-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01265. NadX.
    InterProi IPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR022487. Asp_DH_arc.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
    TIGRFAMsi TIGR03855. NAD_NadX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nankai-3 / ATCC BAA-1280.

    Entry informationi

    Entry nameiASPD_META3
    AccessioniPrimary (citable) accession number: A6UVA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3