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A6UVA8 (ASPD_META3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase

EC=1.4.1.21
Gene names
Name:nadX
Ordered Locus Names:Maeo_0848
OrganismMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP]
Taxonomic identifier419665 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP-Rule MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP-Rule MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP-Rule MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Probable L-aspartate dehydrogenase HAMAP-Rule MF_01265
PRO_1000067302

Sites

Active site2171 By similarity
Binding site1231NAD; via amide nitrogen By similarity
Binding site1891NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A6UVA8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 27EA3020815A7AAA

FASTA26628,532
        10         20         30         40         50         60 
MLKIGIIGCG TIATMIAKAI NYKKINGTIV ALYDKHNDKS QDLNKLTNAK ICDSIDKLVK 

        70         80         90        100        110        120 
EELDIVIECA SIKSVEEVAT KSLNHKKNVV IMSVGALADK NLFSKLYKIA NDNEKKIFVP 

       130        140        150        160        170        180 
SGAIAGVDAI KTASIGRIDE VSLITTKPVY GLEDALKNKG IDTTNISEPT VVFEGTVFDA 

       190        200        210        220        230        240 
IKEFPQNINV SVVLSIASKI PAKVKIVADP SATSNKHEII VKGSIGTIKT VVENNPCKDN 

       250        260 
PKTSALAAYS VIRLLKDLSE PIIVGT 

« Hide

References

[1]"Complete sequence of Methanococcus aeolicus Nankai-3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000743 Genomic DNA. Translation: ABR56430.1.
RefSeqYP_001325042.1. NC_009635.1.

3D structure databases

ProteinModelPortalA6UVA8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING419665.Maeo_0848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR56430; ABR56430; Maeo_0848.
GeneID5326330.
KEGGmae:Maeo_0848.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1712.
HOGENOMHOG000206326.
KOK06989.
OMAPKTSYLA.
ProtClustDBPRK13304.

Enzyme and pathway databases

BioCycMAEO419665:GHVZ-859-MONOMER.
UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01265. NadX.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR022487. Asp_DH_NAD_synth_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
TIGRFAMsTIGR03855. NAD_NadX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD_META3
AccessionPrimary (citable) accession number: A6UVA8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways