A6UV93 (KHSE_META3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Maeo_0833

Organism

Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP]

Taxonomic identifier

419665 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Homoserine kinase HAMAP MF_00384		PRO_1000049142
Regions
	Nucleotide binding	99 – 109	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A6UV93 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 2C451651E96732C2	FASTA	312	33,661
	10 20 30 40 50 60 MKMVKICSPA TSANLGPGYD VFGLALNNPY DTITVSIVEE KGGNETLSNE KITISMEGEK 70 80 90 100 110 120 CEEIPTAVDE NTAGVVAKKM MEDFNIDKNI QIHIEKGIKP GSGLGSSSAS CAGVAVAINE 130 140 150 160 170 180 LFGLELPKLE LVKYASLGEA VAAGAPHADN VAPAIYGGFT MVVNQDPLEI IHIPVEFEVL 190 200 210 220 230 240 VALPNIQIST KEARELVPKE IPIKDMVNNV GKACGMIYSL HDNNVELFGK YMMQDAVVEP 250 260 270 280 290 300 CRATLIDNYS EVKEKVKDLV YGITISGSGP AIISLPKKEC VLEVKKIFKE TWDCPIYYTT 310 LGAGAYVVKE EE

References

[1]

"Complete sequence of Methanococcus aeolicus Nankai-3." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000743 Genomic DNA. Translation: ABR56415.1.
RefSeq	YP_001325027.1. NC_009635.1.
3D structure databases
ProteinModelPortal	A6UV93.
SMR	A6UV93. Positions 1-308.
ModBase	Search...
Protein-protein interaction databases
STRING	A6UV93.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5327004.
GenomeReviews	Gene locus Maeo_0833 in contig CP000743_GR.
KEGG	mae:Maeo_0833.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05905.
HOGENOM	HBG646290.
OMA	GSAHADN.
ProtClustDB	PRK01212.
Enzyme and pathway databases
BioCyc	MAEO419665:MAEO_0833-MONOMER.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_META3

Accession

Primary (citable) accession number: A6UV93

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program