A6UV71 (A6UV71_META3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741
EC=6.3.3.1 HAMAP MF_00741

Alternative name(s):
AIR synthase HAMAP MF_00741
AIRS HAMAP MF_00741
Phosphoribosyl-aminoimidazole synthetase HAMAP MF_00741

Gene names

Name:	purM HAMAP MF_00741
Ordered Locus Names:	Maeo_0810

Organism

Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP] EMBL ABR56393.1

Taxonomic identifier

419665 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity HAMAP MF_00741.
Sequence similarities	Belongs to the AIR synthase family. HAMAP MF_00741

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00741
Cellular component	Cytoplasm HAMAP MF_00741
Ligand	ATP-binding HAMAP MF_00741 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00741 EMBL ABR56393.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6UV71 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 1E6E7648DDF4E2A2	FASTA	351	38,229
	10 20 30 40 50 60 MITYKDAGVD IYKEDKIIKA LVSQIKFKRT DDIKPAEELA GHYAGAIEFG NYYLVLCTDG 70 80 90 100 110 120 VGSKMIVAEM ADKFDTVPID MIAMNVNDAI CIGAEPVALV DYMAVEDITE DMAKQIGKGL 130 140 150 160 170 180 NEGLKESNIN IIGGETASLP DMVKGVDIAG TVLAIAEKGK LILGKDIKKG DVIVGLSSAG 190 200 210 220 230 240 IHSNGLSLAR KVLFDIAGLG INDKLSYGKT VAEELLTPTR IYVKPVMEMI NSEVFVKGLA 250 260 270 280 290 300 HITGGGFRKI IRLNKNIVYL IDNLPEPLPI FKEIQNIGNV KDEEMFKTFN MGIGFCVVVD 310 320 330 340 350 EKDAEEIIKI SEKYNISASI IGKIEDEVEV NGKVVKNTVV VDYNGKKMIM E

References

[1]

"Complete sequence of Methanococcus aeolicus Nankai-3." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000743 Genomic DNA. Translation: ABR56393.1.
RefSeq	YP_001325005.1. NC_009635.1.
3D structure databases
ProteinModelPortal	A6UV71.
ModBase	Search...
Protein-protein interaction databases
STRING	A6UV71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5326735.
GenomeReviews	Gene locus Maeo_0810 in contig CP000743_GR.
KEGG	mae:Maeo_0810.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04189.
HOGENOM	HBG531222.
OMA	GIDMIAM.
ProtClustDB	PRK05385.
Family and domain databases
HAMAP	MF_00741_A. AIRS_A. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6UV71_META3

Accession

Primary (citable) accession number: A6UV71

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)