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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciMAEO419665:G1G9A-700-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:Maeo_0699
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001106 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191691 – 247DNA polymerase sliding clampAdd BLAST247

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi419665.Maeo_0699

Structurei

3D structure databases

ProteinModelPortaliA6UUW0
SMRiA6UUW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiKCANSDD
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

A6UUW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKAVMNAKN FKKIIDSISN LVDEICFEVD ELGIKANAMD PSHVALISVN
60 70 80 90 100
IPKESFDEYV SDTHDIGVDL EALKKIMNRA KPNEKLMLEL DMEKNKLDII
110 120 130 140 150
LKNEGTRKFS ISLYDVSSSN VKVPEIGYPN EVMIKAGTIV ESLKDAELVN
160 170 180 190 200
DHVSLKITED GKFIIYSKGD INTNETVLDR DNESIIELKI SESSKSTYNL
210 220 230 240
AYLKDITKAT SSEDILHIHL GTDMPVKIEY IIGDTKLIYL LAPRIES
Length:247
Mass (Da):27,743
Last modified:August 21, 2007 - v1
Checksum:iD4B8D05FB52F71D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA Translation: ABR56282.1
RefSeqiWP_011973414.1, NC_009635.1

Genome annotation databases

EnsemblBacteriaiABR56282; ABR56282; Maeo_0699
GeneIDi5326566
KEGGimae:Maeo_0699

Similar proteinsi

Entry informationi

Entry nameiPCNA_META3
AccessioniPrimary (citable) accession number: A6UUW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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