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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAEO419665:G1G9A-658-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Maeo_0658
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001106 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987431 – 2242-phospho-L-lactate guanylyltransferaseAdd BLAST224

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi419665.Maeo_0658

Structurei

3D structure databases

ProteinModelPortaliA6UUS0
SMRiA6UUS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472 Archaea
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiFRVDYHG
OrthoDBiPOG093Z0CT7

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

A6UUS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSALIPVSP LNAVKTRLKD FLTPDERIEL IKNMLLDVYE GISPICDKIY
60 70 80 90 100
VVSKDKEILE FLKPYAVIPI METENIKGLN DALNYAFNYI EEDNIIITPA
110 120 130 140 150
DIPLIKKENI NNIVKECKEN SVILCPSRGG GTNLMVLNRS SIKTRYEGFS
160 170 180 190 200
FLKHIEECKE NNINPIIFPS FYISIDINTV EDLGEILIHG GGTYTYNYLK
210 220
KLNINAKPKH SSAGRFEVIR QNTE
Length:224
Mass (Da):25,475
Last modified:August 21, 2007 - v1
Checksum:iD616E30DBDEAC0F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA Translation: ABR56242.1
RefSeqiWP_011973374.1, NC_009635.1

Genome annotation databases

EnsemblBacteriaiABR56242; ABR56242; Maeo_0658
GeneIDi5326798
KEGGimae:Maeo_0658

Similar proteinsi

Entry informationi

Entry nameiCOFC_META3
AccessioniPrimary (citable) accession number: A6UUS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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