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Protein

AMP phosphorylase

Gene

Maeo_0618

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169AMP; via amide nitrogenUniRule annotation1
Binding sitei204AMP; via amide nitrogenUniRule annotation1
Active sitei257Proton donorUniRule annotation1
Binding sitei265AMPUniRule annotation1
Binding sitei289AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 200AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMAEO419665:G1G9A-618-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Maeo_0618
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001106 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147211 – 504AMP phosphorylaseAdd BLAST504

Proteomic databases

PRIDEiA6UUN0

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_0618

Structurei

3D structure databases

ProteinModelPortaliA6UUN0
SMRiA6UUN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A6UUN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLEVKFLD LDLEANAVII NEEDIKGTAY YSQDRVLIES KTCSFIGTLQ
60 70 80 90 100
STKTMIKPGE VGVSKYIKDV KLNEGEEVRV RHAQKPQSVS YIRKKMNGQT
110 120 130 140 150
LTADEIHTII DEIVSKKLTN VELSAFLVST YIRGMNTEEI VAMTKRMAET
160 170 180 190 200
GDTIQWEKRP VVDVHSIGGV PGNKYALLTI PIVAAAGMTI PKTSSRAITS
210 220 230 240 250
AAGTADVLEV ITNVNLSCEE IQRVAKTTGG CLAWGGAVNL APADDIIINV
260 270 280 290 300
ERPLSIDPQP QLLASVMAKK IATGIDYTVI DIPVGYGVKI KNEKEGNQLA
310 320 330 340 350
RKFIELGELL GIRVECVLTY GGQPIGRAIG PALEIKEALM ALHDPKSAPN
360 370 380 390 400
SLIEKSVSLA GVLLELGGRA QIGQGQKVAW EILESGKALE KFNEIVVEQG
410 420 430 440 450
GTITKPEEIE LGEYTMDIRS PKDGYVTGIS NKLITKLAKE AGCPKDKKAG
460 470 480 490 500
IFLGVKTGNK VNKEDILYTI YSSSEERLDA AVNFARRTYP IKVEGMMLKR

LSKF
Length:504
Mass (Da):54,896
Last modified:August 21, 2007 - v1
Checksum:i4677025D2B62C11B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA Translation: ABR56202.1
RefSeqiWP_011973334.1, NC_009635.1

Genome annotation databases

EnsemblBacteriaiABR56202; ABR56202; Maeo_0618
GeneIDi5326374
KEGGimae:Maeo_0618

Similar proteinsi

Entry informationi

Entry nameiAMPPA_META3
AccessioniPrimary (citable) accession number: A6UUN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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