A6UUN0 (TYPH_META3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Maeo_0618

Organism

Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP]

Taxonomic identifier

419665 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus aeolicus

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314721

Sequences

	Sequence		Length	Mass (Da)
	A6UUN0 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 4677025D2B62C11B	FASTA	504	54,896
	10 20 30 40 50 60 MLFLEVKFLD LDLEANAVII NEEDIKGTAY YSQDRVLIES KTCSFIGTLQ STKTMIKPGE 70 80 90 100 110 120 VGVSKYIKDV KLNEGEEVRV RHAQKPQSVS YIRKKMNGQT LTADEIHTII DEIVSKKLTN 130 140 150 160 170 180 VELSAFLVST YIRGMNTEEI VAMTKRMAET GDTIQWEKRP VVDVHSIGGV PGNKYALLTI 190 200 210 220 230 240 PIVAAAGMTI PKTSSRAITS AAGTADVLEV ITNVNLSCEE IQRVAKTTGG CLAWGGAVNL 250 260 270 280 290 300 APADDIIINV ERPLSIDPQP QLLASVMAKK IATGIDYTVI DIPVGYGVKI KNEKEGNQLA 310 320 330 340 350 360 RKFIELGELL GIRVECVLTY GGQPIGRAIG PALEIKEALM ALHDPKSAPN SLIEKSVSLA 370 380 390 400 410 420 GVLLELGGRA QIGQGQKVAW EILESGKALE KFNEIVVEQG GTITKPEEIE LGEYTMDIRS 430 440 450 460 470 480 PKDGYVTGIS NKLITKLAKE AGCPKDKKAG IFLGVKTGNK VNKEDILYTI YSSSEERLDA 490 500 AVNFARRTYP IKVEGMMLKR LSKF

References

[1]

"Complete sequence of Methanococcus aeolicus Nankai-3." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000743 Genomic DNA. Translation: ABR56202.1.
RefSeq	YP_001324814.1. NC_009635.1.
3D structure databases
ProteinModelPortal	A6UUN0.
ModBase	Search...
Protein-protein interaction databases
STRING	419665.Maeo_0618.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR56202; ABR56202; Maeo_0618.
GeneID	5326374.
KEGG	mae:Maeo_0618.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	MAEO419665:GHVZ-621-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_META3

Accession

Primary (citable) accession number: A6UUN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	May 29, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program