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Protein

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase

Gene

aroA'

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.UniRule annotation

Catalytic activityi

L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + 2,3-dioxopropylaldehyde phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33Proton acceptorUniRule annotation1
Active sitei153Proton donorUniRule annotation1
Active sitei184Schiff-base intermediate with substrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

Schiff base

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthaseUniRule annotation (EC:2.2.1.10UniRule annotation)
Short name:
ADH synthaseUniRule annotation
Short name:
ADHSUniRule annotation
Short name:
ADTH synthaseUniRule annotation
Gene namesi
Name:aroA'UniRule annotation
Ordered Locus Names:Maeo_0316
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001106 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003636671 – 2712-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthaseAdd BLAST271

Interactioni

Subunit structurei

Homodecamer.UniRule annotation

Protein-protein interaction databases

STRINGi419665.Maeo_0316.

Structurei

3D structure databases

ProteinModelPortaliA6UTT2.
SMRiA6UTT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 37DKFP bindingUniRule annotation5
Regioni153 – 155DKFP bindingUniRule annotation3
Regioni209 – 210DKFP bindingUniRule annotation2
Regioni236 – 237DKFP bindingUniRule annotation2

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04044. Archaea.
COG1830. LUCA.
HOGENOMiHOG000224790.
KOiK16306.
OMAiIVRHGHR.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00960. ADH_synthase. 1 hit.
InterProiIPR010210. ADH_synthase.
IPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01949. AroFGH_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UTT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMFNNIKNT GKLIRLERIF DKKSEKTVII PMDHGVSSGP VAGLKDMRTA
60 70 80 90 100
INSVAEGGAN SVLVHKGIVR HGHRGYGKDI GLIIHLSAGT GVSPDPNEKV
110 120 130 140 150
IVTSVEEAIR MGADAVSVHV NMGAPTDCQM YQDLGKIAET CEYWGMPLIA
160 170 180 190 200
MMYPRGEKIT DEKDPEFVAH AARLGAELGA DIIKTNYTGD IDSFKDVVKG
210 220 230 240 250
CPAPIIIAGG AKSTDAEYLQ MVKDSIEAGG AGVASGRNVF QHKDVIGITK
260 270
ATAMVVHENA DVEEALKVIK K
Length:271
Mass (Da):28,967
Last modified:August 21, 2007 - v1
Checksum:i718C3BF08E6AEB3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR55904.1.
RefSeqiWP_011973036.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR55904; ABR55904; Maeo_0316.
GeneIDi5327000.
KEGGimae:Maeo_0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR55904.1.
RefSeqiWP_011973036.1. NC_009635.1.

3D structure databases

ProteinModelPortaliA6UTT2.
SMRiA6UTT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419665.Maeo_0316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR55904; ABR55904; Maeo_0316.
GeneIDi5327000.
KEGGimae:Maeo_0316.

Phylogenomic databases

eggNOGiarCOG04044. Archaea.
COG1830. LUCA.
HOGENOMiHOG000224790.
KOiK16306.
OMAiIVRHGHR.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00960. ADH_synthase. 1 hit.
InterProiIPR010210. ADH_synthase.
IPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01949. AroFGH_arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADHS_META3
AccessioniPrimary (citable) accession number: A6UTT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.