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A6UTK3

- SYL_META3

UniProt

A6UTK3 - SYL_META3

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Protein
Leucine--tRNA ligase
Gene
leuS, Maeo_0233
Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei661 – 6611ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAEO419665:GHVZ-235-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Maeo_0233
OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001106: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 969969Leucine--tRNA ligaseUniRule annotation
PRO_0000334843Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_0233.

Structurei

3D structure databases

ProteinModelPortaliA6UTK3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionUniRule annotation
Add
BLAST
Motifi658 – 6625"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6UTK3-1 [UniParc]FASTAAdd to Basket

« Hide

MSVDFVKIAE KWQKRWEEDK IFENPSKLKY TEQEKKDKFF ITAAFPYLNG    50
VLHAGHLRTF TIPEITARYQ RMNNKTVLWT FGFHVSGTPI IGLAELLKKQ 100
APETIWAYNK LHNIPMGELQ TLTTPENIVN YFSKKATESF KKMGFALDWR 150
RNFKTDDETF KKFVEWQFLK LKEKNLIVKG SHPVRYCPSC DNPVEDHDLL 200
KGEEATLQEY ILLKFKTKLN IEIDGEDKEY ECIIPMATLR PETIYGVVNA 250
WINPNDTYHI IKVYDEVQSQ EEGSDEISLK YNGIWIVSKE ASDKLKNQDR 300
TVELIKEIKG EELVGKIVIN PVNNKEVPLY PADFVSSEMG TGCVMSVPAH 350
APKDFVALRD YYSSINKELT DDELISLIKI DGYGKYPAKE IVEKMGITNQ 400
KDEKLEDATH TIYKQEFHKG ILNENCGEYE GIAVRDIKDK LASDFINNNM 450
AETLQEFSIP EVVCRCGEKC IVKTVKGQWF ITYSDLEWKK KAHNWVDKMN 500
FVPETIRMDF HNKIDWMKDK ACARKKGLGT RFPFDKDWVI ESLSDSTLYM 550
AYYTVAKTIN TNNILPEQLI PELFDYVYYG KGDINEISNN TKIPVELINE 600
MRNEFEYYYP LDWRCSAKDL VPNHLTFMIF NHVALFDDEK YYPKGIVVNG 650
YVTIEGKKLS KSKGPVLPIE EVATNYGPDV GRFYITTCAE LPHDADVKFK 700
EMEHARDNLI RFYELATELK DTEKTITELS TIDKWLLHKV HSDLKIINES 750
YNEFQLRKIG TLFYGLTHNL KWYKRRGGNN NQLLKYVVEI WTKVLAPITP 800
HLCEEIWEMF GYNKNNNYIS NETFPQLDNS YINENCELGE EFIKNTMDDI 850
RNIINIANIA PKTIYLYTAD DWKFEVLKIM MENKGAPVNK MMPLIMKNAE 900
LRRYGKEIPK LINEIVKNGI SNPIDEENIL NDAKQFLENE FQCKIIVNGE 950
DIGNKKRFAI PNKVAIYIE 969
Length:969
Mass (Da):112,812
Last modified:August 21, 2007 - v1
Checksum:iBEF958BA8BD0A60F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR55825.1.
RefSeqiWP_011972957.1. NC_009635.1.
YP_001324437.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR55825; ABR55825; Maeo_0233.
GeneIDi5326548.
KEGGimae:Maeo_0233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR55825.1 .
RefSeqi WP_011972957.1. NC_009635.1.
YP_001324437.1. NC_009635.1.

3D structure databases

ProteinModelPortali A6UTK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419665.Maeo_0233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR55825 ; ABR55825 ; Maeo_0233 .
GeneIDi 5326548.
KEGGi mae:Maeo_0233.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci MAEO419665:GHVZ-235-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nankai-3 / ATCC BAA-1280.

Entry informationi

Entry nameiSYL_META3
AccessioniPrimary (citable) accession number: A6UTK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi