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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei661ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAEO419665:G1G9A-235-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Maeo_0233
OrganismiMethanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001106 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003348431 – 969Leucine--tRNA ligaseAdd BLAST969

Proteomic databases

PRIDEiA6UTK3

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_0233

Structurei

3D structure databases

ProteinModelPortaliA6UTK3
SMRiA6UTK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 56"HIGH" regionAdd BLAST11
Motifi658 – 662"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A6UTK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDFVKIAE KWQKRWEEDK IFENPSKLKY TEQEKKDKFF ITAAFPYLNG
60 70 80 90 100
VLHAGHLRTF TIPEITARYQ RMNNKTVLWT FGFHVSGTPI IGLAELLKKQ
110 120 130 140 150
APETIWAYNK LHNIPMGELQ TLTTPENIVN YFSKKATESF KKMGFALDWR
160 170 180 190 200
RNFKTDDETF KKFVEWQFLK LKEKNLIVKG SHPVRYCPSC DNPVEDHDLL
210 220 230 240 250
KGEEATLQEY ILLKFKTKLN IEIDGEDKEY ECIIPMATLR PETIYGVVNA
260 270 280 290 300
WINPNDTYHI IKVYDEVQSQ EEGSDEISLK YNGIWIVSKE ASDKLKNQDR
310 320 330 340 350
TVELIKEIKG EELVGKIVIN PVNNKEVPLY PADFVSSEMG TGCVMSVPAH
360 370 380 390 400
APKDFVALRD YYSSINKELT DDELISLIKI DGYGKYPAKE IVEKMGITNQ
410 420 430 440 450
KDEKLEDATH TIYKQEFHKG ILNENCGEYE GIAVRDIKDK LASDFINNNM
460 470 480 490 500
AETLQEFSIP EVVCRCGEKC IVKTVKGQWF ITYSDLEWKK KAHNWVDKMN
510 520 530 540 550
FVPETIRMDF HNKIDWMKDK ACARKKGLGT RFPFDKDWVI ESLSDSTLYM
560 570 580 590 600
AYYTVAKTIN TNNILPEQLI PELFDYVYYG KGDINEISNN TKIPVELINE
610 620 630 640 650
MRNEFEYYYP LDWRCSAKDL VPNHLTFMIF NHVALFDDEK YYPKGIVVNG
660 670 680 690 700
YVTIEGKKLS KSKGPVLPIE EVATNYGPDV GRFYITTCAE LPHDADVKFK
710 720 730 740 750
EMEHARDNLI RFYELATELK DTEKTITELS TIDKWLLHKV HSDLKIINES
760 770 780 790 800
YNEFQLRKIG TLFYGLTHNL KWYKRRGGNN NQLLKYVVEI WTKVLAPITP
810 820 830 840 850
HLCEEIWEMF GYNKNNNYIS NETFPQLDNS YINENCELGE EFIKNTMDDI
860 870 880 890 900
RNIINIANIA PKTIYLYTAD DWKFEVLKIM MENKGAPVNK MMPLIMKNAE
910 920 930 940 950
LRRYGKEIPK LINEIVKNGI SNPIDEENIL NDAKQFLENE FQCKIIVNGE
960
DIGNKKRFAI PNKVAIYIE
Length:969
Mass (Da):112,812
Last modified:August 21, 2007 - v1
Checksum:iBEF958BA8BD0A60F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA Translation: ABR55825.1
RefSeqiWP_011972957.1, NC_009635.1

Genome annotation databases

EnsemblBacteriaiABR55825; ABR55825; Maeo_0233
GeneIDi5326548
KEGGimae:Maeo_0233

Similar proteinsi

Entry informationi

Entry nameiSYL_META3
AccessioniPrimary (citable) accession number: A6UTK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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