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A6UTK3 (SYL_META3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Maeo_0233
OrganismMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP]
Taxonomic identifier419665 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length969 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 969969Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334843

Regions

Motif46 – 5611"HIGH" region HAMAP-Rule MF_00049
Motif658 – 6625"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6611ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6UTK3 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: BEF958BA8BD0A60F

FASTA969112,812
        10         20         30         40         50         60 
MSVDFVKIAE KWQKRWEEDK IFENPSKLKY TEQEKKDKFF ITAAFPYLNG VLHAGHLRTF 

        70         80         90        100        110        120 
TIPEITARYQ RMNNKTVLWT FGFHVSGTPI IGLAELLKKQ APETIWAYNK LHNIPMGELQ 

       130        140        150        160        170        180 
TLTTPENIVN YFSKKATESF KKMGFALDWR RNFKTDDETF KKFVEWQFLK LKEKNLIVKG 

       190        200        210        220        230        240 
SHPVRYCPSC DNPVEDHDLL KGEEATLQEY ILLKFKTKLN IEIDGEDKEY ECIIPMATLR 

       250        260        270        280        290        300 
PETIYGVVNA WINPNDTYHI IKVYDEVQSQ EEGSDEISLK YNGIWIVSKE ASDKLKNQDR 

       310        320        330        340        350        360 
TVELIKEIKG EELVGKIVIN PVNNKEVPLY PADFVSSEMG TGCVMSVPAH APKDFVALRD 

       370        380        390        400        410        420 
YYSSINKELT DDELISLIKI DGYGKYPAKE IVEKMGITNQ KDEKLEDATH TIYKQEFHKG 

       430        440        450        460        470        480 
ILNENCGEYE GIAVRDIKDK LASDFINNNM AETLQEFSIP EVVCRCGEKC IVKTVKGQWF 

       490        500        510        520        530        540 
ITYSDLEWKK KAHNWVDKMN FVPETIRMDF HNKIDWMKDK ACARKKGLGT RFPFDKDWVI 

       550        560        570        580        590        600 
ESLSDSTLYM AYYTVAKTIN TNNILPEQLI PELFDYVYYG KGDINEISNN TKIPVELINE 

       610        620        630        640        650        660 
MRNEFEYYYP LDWRCSAKDL VPNHLTFMIF NHVALFDDEK YYPKGIVVNG YVTIEGKKLS 

       670        680        690        700        710        720 
KSKGPVLPIE EVATNYGPDV GRFYITTCAE LPHDADVKFK EMEHARDNLI RFYELATELK 

       730        740        750        760        770        780 
DTEKTITELS TIDKWLLHKV HSDLKIINES YNEFQLRKIG TLFYGLTHNL KWYKRRGGNN 

       790        800        810        820        830        840 
NQLLKYVVEI WTKVLAPITP HLCEEIWEMF GYNKNNNYIS NETFPQLDNS YINENCELGE 

       850        860        870        880        890        900 
EFIKNTMDDI RNIINIANIA PKTIYLYTAD DWKFEVLKIM MENKGAPVNK MMPLIMKNAE 

       910        920        930        940        950        960 
LRRYGKEIPK LINEIVKNGI SNPIDEENIL NDAKQFLENE FQCKIIVNGE DIGNKKRFAI 


PNKVAIYIE 

« Hide

References

[1]"Complete sequence of Methanococcus aeolicus Nankai-3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000743 Genomic DNA. Translation: ABR55825.1.
RefSeqYP_001324437.1. NC_009635.1.

3D structure databases

ProteinModelPortalA6UTK3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING419665.Maeo_0233.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR55825; ABR55825; Maeo_0233.
GeneID5326548.
KEGGmae:Maeo_0233.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000216620.
KOK01869.
OMAIMNDLRW.
ProtClustDBPRK12300.

Enzyme and pathway databases

BioCycMAEO419665:GHVZ-235-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_A. Leu_tRNA_synth_A.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_META3
AccessionPrimary (citable) accession number: A6UTK3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries