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A6UTK3

- SYL_META3

UniProt

A6UTK3 - SYL_META3

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei661 – 6611ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMAEO419665:GHVZ-235-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Maeo_0233
    OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
    Taxonomic identifieri419665 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000001106: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 969969Leucine--tRNA ligasePRO_0000334843Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi419665.Maeo_0233.

    Structurei

    3D structure databases

    ProteinModelPortaliA6UTK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 5611"HIGH" regionAdd
    BLAST
    Motifi658 – 6625"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiIDKWLLH.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6UTK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVDFVKIAE KWQKRWEEDK IFENPSKLKY TEQEKKDKFF ITAAFPYLNG    50
    VLHAGHLRTF TIPEITARYQ RMNNKTVLWT FGFHVSGTPI IGLAELLKKQ 100
    APETIWAYNK LHNIPMGELQ TLTTPENIVN YFSKKATESF KKMGFALDWR 150
    RNFKTDDETF KKFVEWQFLK LKEKNLIVKG SHPVRYCPSC DNPVEDHDLL 200
    KGEEATLQEY ILLKFKTKLN IEIDGEDKEY ECIIPMATLR PETIYGVVNA 250
    WINPNDTYHI IKVYDEVQSQ EEGSDEISLK YNGIWIVSKE ASDKLKNQDR 300
    TVELIKEIKG EELVGKIVIN PVNNKEVPLY PADFVSSEMG TGCVMSVPAH 350
    APKDFVALRD YYSSINKELT DDELISLIKI DGYGKYPAKE IVEKMGITNQ 400
    KDEKLEDATH TIYKQEFHKG ILNENCGEYE GIAVRDIKDK LASDFINNNM 450
    AETLQEFSIP EVVCRCGEKC IVKTVKGQWF ITYSDLEWKK KAHNWVDKMN 500
    FVPETIRMDF HNKIDWMKDK ACARKKGLGT RFPFDKDWVI ESLSDSTLYM 550
    AYYTVAKTIN TNNILPEQLI PELFDYVYYG KGDINEISNN TKIPVELINE 600
    MRNEFEYYYP LDWRCSAKDL VPNHLTFMIF NHVALFDDEK YYPKGIVVNG 650
    YVTIEGKKLS KSKGPVLPIE EVATNYGPDV GRFYITTCAE LPHDADVKFK 700
    EMEHARDNLI RFYELATELK DTEKTITELS TIDKWLLHKV HSDLKIINES 750
    YNEFQLRKIG TLFYGLTHNL KWYKRRGGNN NQLLKYVVEI WTKVLAPITP 800
    HLCEEIWEMF GYNKNNNYIS NETFPQLDNS YINENCELGE EFIKNTMDDI 850
    RNIINIANIA PKTIYLYTAD DWKFEVLKIM MENKGAPVNK MMPLIMKNAE 900
    LRRYGKEIPK LINEIVKNGI SNPIDEENIL NDAKQFLENE FQCKIIVNGE 950
    DIGNKKRFAI PNKVAIYIE 969
    Length:969
    Mass (Da):112,812
    Last modified:August 21, 2007 - v1
    Checksum:iBEF958BA8BD0A60F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000743 Genomic DNA. Translation: ABR55825.1.
    RefSeqiWP_011972957.1. NC_009635.1.
    YP_001324437.1. NC_009635.1.

    Genome annotation databases

    EnsemblBacteriaiABR55825; ABR55825; Maeo_0233.
    GeneIDi5326548.
    KEGGimae:Maeo_0233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000743 Genomic DNA. Translation: ABR55825.1 .
    RefSeqi WP_011972957.1. NC_009635.1.
    YP_001324437.1. NC_009635.1.

    3D structure databases

    ProteinModelPortali A6UTK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419665.Maeo_0233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR55825 ; ABR55825 ; Maeo_0233 .
    GeneIDi 5326548.
    KEGGi mae:Maeo_0233.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi IDKWLLH.

    Enzyme and pathway databases

    BioCyci MAEO419665:GHVZ-235-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nankai-3 / ATCC BAA-1280.

    Entry informationi

    Entry nameiSYL_META3
    AccessioniPrimary (citable) accession number: A6UTK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3