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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei661 – 6611ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAEO419665:GHVZ-235-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Maeo_0233
OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001106: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 969969Leucine--tRNA ligasePRO_0000334843Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_0233.

Structurei

3D structure databases

ProteinModelPortaliA6UTK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionAdd
BLAST
Motifi658 – 6625"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiSEHFPKT.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6UTK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDFVKIAE KWQKRWEEDK IFENPSKLKY TEQEKKDKFF ITAAFPYLNG
60 70 80 90 100
VLHAGHLRTF TIPEITARYQ RMNNKTVLWT FGFHVSGTPI IGLAELLKKQ
110 120 130 140 150
APETIWAYNK LHNIPMGELQ TLTTPENIVN YFSKKATESF KKMGFALDWR
160 170 180 190 200
RNFKTDDETF KKFVEWQFLK LKEKNLIVKG SHPVRYCPSC DNPVEDHDLL
210 220 230 240 250
KGEEATLQEY ILLKFKTKLN IEIDGEDKEY ECIIPMATLR PETIYGVVNA
260 270 280 290 300
WINPNDTYHI IKVYDEVQSQ EEGSDEISLK YNGIWIVSKE ASDKLKNQDR
310 320 330 340 350
TVELIKEIKG EELVGKIVIN PVNNKEVPLY PADFVSSEMG TGCVMSVPAH
360 370 380 390 400
APKDFVALRD YYSSINKELT DDELISLIKI DGYGKYPAKE IVEKMGITNQ
410 420 430 440 450
KDEKLEDATH TIYKQEFHKG ILNENCGEYE GIAVRDIKDK LASDFINNNM
460 470 480 490 500
AETLQEFSIP EVVCRCGEKC IVKTVKGQWF ITYSDLEWKK KAHNWVDKMN
510 520 530 540 550
FVPETIRMDF HNKIDWMKDK ACARKKGLGT RFPFDKDWVI ESLSDSTLYM
560 570 580 590 600
AYYTVAKTIN TNNILPEQLI PELFDYVYYG KGDINEISNN TKIPVELINE
610 620 630 640 650
MRNEFEYYYP LDWRCSAKDL VPNHLTFMIF NHVALFDDEK YYPKGIVVNG
660 670 680 690 700
YVTIEGKKLS KSKGPVLPIE EVATNYGPDV GRFYITTCAE LPHDADVKFK
710 720 730 740 750
EMEHARDNLI RFYELATELK DTEKTITELS TIDKWLLHKV HSDLKIINES
760 770 780 790 800
YNEFQLRKIG TLFYGLTHNL KWYKRRGGNN NQLLKYVVEI WTKVLAPITP
810 820 830 840 850
HLCEEIWEMF GYNKNNNYIS NETFPQLDNS YINENCELGE EFIKNTMDDI
860 870 880 890 900
RNIINIANIA PKTIYLYTAD DWKFEVLKIM MENKGAPVNK MMPLIMKNAE
910 920 930 940 950
LRRYGKEIPK LINEIVKNGI SNPIDEENIL NDAKQFLENE FQCKIIVNGE
960
DIGNKKRFAI PNKVAIYIE
Length:969
Mass (Da):112,812
Last modified:August 21, 2007 - v1
Checksum:iBEF958BA8BD0A60F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR55825.1.
RefSeqiWP_011972957.1. NC_009635.1.
YP_001324437.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR55825; ABR55825; Maeo_0233.
GeneIDi5326548.
KEGGimae:Maeo_0233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000743 Genomic DNA. Translation: ABR55825.1.
RefSeqiWP_011972957.1. NC_009635.1.
YP_001324437.1. NC_009635.1.

3D structure databases

ProteinModelPortaliA6UTK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419665.Maeo_0233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR55825; ABR55825; Maeo_0233.
GeneIDi5326548.
KEGGimae:Maeo_0233.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiSEHFPKT.

Enzyme and pathway databases

BioCyciMAEO419665:GHVZ-235-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nankai-3 / ATCC BAA-1280.

Entry informationi

Entry nameiSYL_META3
AccessioniPrimary (citable) accession number: A6UTK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.