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A6UTH4 (DAPF_META3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Diaminopimelate epimerase
Short name=DAP epimerase
EC=5.1.1.7
Gene names
Name:dapF
Ordered Locus Names:Maeo_0204
OrganismMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280) [Complete proteome] [HAMAP]
Taxonomic identifier419665 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. HAMAP MF_00197

Subcellular location

Cytoplasm By similarity HAMAP MF_00197.

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlysine biosynthetic process via diaminopimelate

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondiaminopimelate epimerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Diaminopimelate epimerase HAMAP MF_00197
PRO_1000011903

Sites

Active site781 By similarity
Active site2391 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6UTH4 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 5547FADE4D5EF07D

FASTA29532,981
        10         20         30         40         50         60 
MGLNFTKMHG LGNDYIVINE FDGEKIKEDE KAEFSKKICK RGFSIGADGV IFVQPATDEK 

        70         80         90        100        110        120 
YDIRFRIFNS DGSEAEMCGN GIRCFSKFVY ERVMQKNPLN VETMGGLRVS EMNIENNIVK 

       130        140        150        160        170        180 
SIKVFMGAPT FELKDIPMVV EGKSENDVFL DEEIELKNAL LNSVKLSVVN VGNPHAVIFM 

       190        200        210        220        230        240 
KDNNLKAPFI RTHLNILGKE IEHHSVFPEK INVHFVEIVN PQEIKIITWE RGAGYTTACG 

       250        260        270        280        290 
TGTTSSVIIA NKLGKTGNKV LAHLDGGDLE IEIKEDGVYM EGDAVIVYDG ELYQY

« Hide

References

[1]"Complete sequence of Methanococcus aeolicus Nankai-3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nankai-3 / ATCC BAA-1280.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000743 Genomic DNA. Translation: ABR55796.1.
RefSeqYP_001324408.1. NC_009635.1.

3D structure databases

ProteinModelPortalA6UTH4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6UTH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5326820.
GenomeReviewsGene locus Maeo_0204 in contig CP000743_GR.
KEGGmae:Maeo_0204.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG07445.
HOGENOMHBG399442.
OMAFMTGPAT.
ProtClustDBPRK00450.

Enzyme and pathway databases

BioCycMAEO419665:MAEO_0204-MONOMER.

Family and domain databases

HAMAPMF_00197. DAP_epimerase.
[Tree]
InterProIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
KOK01778.
PfamPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsTIGR00652. DapF. 1 hit.
PROSITEPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPF_META3
AccessionPrimary (citable) accession number: A6UTH4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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