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A6UTH4

- DAPF_META3

UniProt

A6UTH4 - DAPF_META3

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Protein

Diaminopimelate epimerase

Gene
dapF, Maeo_0204
Organism
Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131Substrate By similarity
Binding sitei49 – 491Substrate By similarity
Binding sitei69 – 691Substrate By similarity
Active sitei78 – 781Proton donor/acceptor By similarity
Binding sitei173 – 1731Substrate By similarity
Sitei175 – 1751Important for catalytic activity By similarity
Binding sitei212 – 2121Substrate By similarity
Sitei230 – 2301Important for catalytic activity By similarity
Active sitei239 – 2391Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciMAEO419665:GHVZ-205-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:Maeo_0204
OrganismiMethanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280)
Taxonomic identifieri419665 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001106: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Diaminopimelate epimeraseUniRule annotationPRO_1000011903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 239UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi419665.Maeo_0204.

Structurei

3D structure databases

ProteinModelPortaliA6UTH4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 112Substrate binding By similarity
Regioni78 – 803Substrate binding By similarity
Regioni230 – 2312Substrate binding By similarity
Regioni240 – 2412Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiKHINREQ.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6UTH4-1 [UniParc]FASTAAdd to Basket

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MGLNFTKMHG LGNDYIVINE FDGEKIKEDE KAEFSKKICK RGFSIGADGV    50
IFVQPATDEK YDIRFRIFNS DGSEAEMCGN GIRCFSKFVY ERVMQKNPLN 100
VETMGGLRVS EMNIENNIVK SIKVFMGAPT FELKDIPMVV EGKSENDVFL 150
DEEIELKNAL LNSVKLSVVN VGNPHAVIFM KDNNLKAPFI RTHLNILGKE 200
IEHHSVFPEK INVHFVEIVN PQEIKIITWE RGAGYTTACG TGTTSSVIIA 250
NKLGKTGNKV LAHLDGGDLE IEIKEDGVYM EGDAVIVYDG ELYQY 295
Length:295
Mass (Da):32,981
Last modified:August 21, 2007 - v1
Checksum:i5547FADE4D5EF07D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR55796.1.
RefSeqiYP_001324408.1. NC_009635.1.

Genome annotation databases

EnsemblBacteriaiABR55796; ABR55796; Maeo_0204.
GeneIDi5326820.
KEGGimae:Maeo_0204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000743 Genomic DNA. Translation: ABR55796.1 .
RefSeqi YP_001324408.1. NC_009635.1.

3D structure databases

ProteinModelPortali A6UTH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419665.Maeo_0204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR55796 ; ABR55796 ; Maeo_0204 .
GeneIDi 5326820.
KEGGi mae:Maeo_0204.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi KHINREQ.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci MAEO419665:GHVZ-205-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nankai-3 / ATCC BAA-1280.

Entry informationi

Entry nameiDAPF_META3
AccessioniPrimary (citable) accession number: A6UTH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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