A6USW4 (A6USW4_METVS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
EC=6.3.2.6 HAMAP MF_00137

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137
Ordered Locus Names:	Mevan_1694

Organism

Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]

Taxonomic identifier

406327 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137 RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137
Ligand	ATP-binding HAMAP MF_00137 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 EMBL ABR55586.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6USW4 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 27E2362F818773A3	FASTA	244	27,569
	10 20 30 40 50 60 MDYDILKIME KAPLYSGKAK SVYEIEGTDE VLVEFRDDIT AGNGLKHDVK SGKGYLNTII 70 80 90 100 110 120 SVELFKLLEE NGVQTHFIKY VEPSHMISKK VDIIPLEVIV RNVAAGSLCK KYPFESGKDL 130 140 150 160 170 180 ETPILQFDYK NDDYGDPMLN NEIAIALNLA TEEELAEIKK LALEVNTVLK NYFDTIGIIL 190 200 210 220 230 240 VDFKIEVGKT SDGKIIVADE ISPDTMRLWD KETKDVLDKD VFRKDLGDVL EKYRIVAKKI GCLK

References

[1]

"Complete sequence of Methanococcus vannielii SB." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000742 Genomic DNA. Translation: ABR55586.1.
RefSeq	YP_001324198.1. NC_009634.1.
3D structure databases
ProteinModelPortal	A6USW4.
SMR	A6USW4. Positions 1-243.
ModBase	Search...
Protein-protein interaction databases
STRING	A6USW4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5325209.
GenomeReviews	Gene locus Mevan_1694 in contig CP000742_GR.
KEGG	mvn:Mevan_1694.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05989.
HOGENOM	HBG306070.
OMA	YKDDALG.
ProtClustDB	PRK09362.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A6USW4_METVS

Accession

Primary (citable) accession number: A6USW4

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)