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A6USM7 (ASPD_METVS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase

EC=1.4.1.21
Gene names
Name:nadX
Ordered Locus Names:Mevan_1607
OrganismMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]
Taxonomic identifier406327 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP-Rule MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP-Rule MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP-Rule MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Probable L-aspartate dehydrogenase HAMAP-Rule MF_01265
PRO_1000067308

Sites

Active site2181 By similarity
Binding site1241NAD; via amide nitrogen By similarity
Binding site1901NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A6USM7 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: A12E6B40833F3490

FASTA26728,603
        10         20         30         40         50         60 
MLKVGIVGCG AVASLITKAL LSERIPKARV LAFYDVNYEK AKKLSEETGA ESCVSIDELV 

        70         80         90        100        110        120 
SKDLDLILEC ASVSAVEETV LKSILSGKDV IIMSVGAFAN KKLFLNLYKL AEEKNQKIYV 

       130        140        150        160        170        180 
PSGAVAGIDA IKAGSLGQIS DVTLTTTKPV MGLKDAILDL GLKPEEITEP KVVFEGNVFE 

       190        200        210        220        230        240 
AISKFPQNIN VSVVLSLASK YPAKVKIIAD PNLIVNRHEI LVKGSIGTIK TCVENNPCKD 

       250        260 
NPKTSALAAF SVMRLIKDLS EPIRIGT 

« Hide

References

[1]"Complete sequence of Methanococcus vannielii SB."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000742 Genomic DNA. Translation: ABR55499.1.
RefSeqYP_001324111.1. NC_009634.1.

3D structure databases

ProteinModelPortalA6USM7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING406327.Mevan_1607.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR55499; ABR55499; Mevan_1607.
GeneID5324920.
KEGGmvn:Mevan_1607.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1712.
HOGENOMHOG000206326.
KOK06989.
OMAECAGHSA.

Enzyme and pathway databases

BioCycMVAN406327:GI04-1657-MONOMER.
UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01265. NadX.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR022487. Asp_DH_NAD_synth_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
TIGRFAMsTIGR03855. NAD_NadX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD_METVS
AccessionPrimary (citable) accession number: A6USM7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways