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A6USJ5

- SYL_METVS

UniProt

A6USJ5 - SYL_METVS

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei647 – 6471ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMVAN406327:GI04-1624-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mevan_1575
    OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
    Taxonomic identifieri406327 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000001107: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 952952Leucine--tRNA ligasePRO_0000334846Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi406327.Mevan_1575.

    Structurei

    3D structure databases

    ProteinModelPortaliA6USJ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 5811"HIGH" regionAdd
    BLAST
    Motifi644 – 6485"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiIDKWLLH.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6USJ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVENMETSFK SIDLIQIMDK WQRKWDESKI FETKHDNREK FFISAAFPYL    50
    NGVLHAGHLR TFTIPETIAR YQRMKNKNVL WTFGFHVTGT PILGLANQIK 100
    EKKEDIIWAY TNLHNIPMDE LLKLDTPEAI VECFSKKATD AFKKMGFSLD 150
    WRRNFKTDDK VFSKFIEWQF YKLKDLGLIK KGSHPVRYCP KCENPVEDHD 200
    LLHGEESTTV EYNLIKFTST FDEKDVIIPM ATLRPETVFG VTNAWVNPDE 250
    IYVLAEVYDE IQKLDSEDVD LKYNGLWIVG KECADKLKEQ DKNIKILKEF 300
    KGSELIGLKI KNPVTNLKVP IFPAEFVEMN IGTGCVMSVP AHAPYDYVAL 350
    RDLEKVEEVG LISLIEIEGY GKYPAKEIVE KMNIKNQKDE ALLEEATSKI 400
    YKDEFHKGKL NENCPEYKGT SVKDIKEKLI KDYMNFGISE IMYEFSEPKV 450
    VCRCGEKCII KTVKGQWFIT YSDENWKRLA HECIDSMEFA PENLRHEFHN 500
    KIDWMKDKAC ARRKGLGTKL PFDTNWMIES LSDSTIYMAY YTIARFINAG 550
    INENQLTSEL FEYVFSGNGN LAEISNVSEV SIEIIEEMRK EFLYFYPLDW 600
    RCSAKDLIPN HLSFMIFNHV ALFKKEHWPR GIEINGYVTI EGKKLSKSKG 650
    PVLPVLEVSE TFGADVARFY ITTCAELPQD ADVKFKEMEK ARDNLIKLYE 700
    LAVLVTKEGI IEKELSIIDK WLLHKTHSSI NFAEKAYEEF HLRKIGLMFY 750
    ELINDLRWYK RRGGDNNGVL KEVVEIWTKL LSPVTPHLCE EIWELLGHNG 800
    FISKEIFPNV KIEYINEELE LGEEFIRFTM EDIRNIKNVA KINPEKMYLY 850
    TADDWKYELL EFMNKNSEKN VKELIPIVMK EERFKRHGKD VMKLINDLMK 900
    VGVKKAIAEV EILENAKTFI EKEFECNVII GGEDFNGKKK FAIPYKPAIY 950
    ME 952
    Length:952
    Mass (Da):111,051
    Last modified:August 21, 2007 - v1
    Checksum:i13D20D32E0B8A923
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000742 Genomic DNA. Translation: ABR55467.1.
    RefSeqiYP_001324079.1. NC_009634.1.

    Genome annotation databases

    EnsemblBacteriaiABR55467; ABR55467; Mevan_1575.
    GeneIDi5325458.
    KEGGimvn:Mevan_1575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000742 Genomic DNA. Translation: ABR55467.1 .
    RefSeqi YP_001324079.1. NC_009634.1.

    3D structure databases

    ProteinModelPortali A6USJ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 406327.Mevan_1575.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR55467 ; ABR55467 ; Mevan_1575 .
    GeneIDi 5325458.
    KEGGi mvn:Mevan_1575.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi IDKWLLH.

    Enzyme and pathway databases

    BioCyci MVAN406327:GI04-1624-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB / ATCC 35089 / DSM 1224.

    Entry informationi

    Entry nameiSYL_METVS
    AccessioniPrimary (citable) accession number: A6USJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3