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A6USJ5

- SYL_METVS

UniProt

A6USJ5 - SYL_METVS

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Protein
Leucine--tRNA ligase
Gene
leuS, Mevan_1575
Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei647 – 6471ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN406327:GI04-1624-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Mevan_1575
OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001107: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Leucine--tRNA ligaseUniRule annotation
PRO_0000334846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi406327.Mevan_1575.

Structurei

3D structure databases

ProteinModelPortaliA6USJ5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotation
Add
BLAST
Motifi644 – 6485"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6USJ5-1 [UniParc]FASTAAdd to Basket

« Hide

MVENMETSFK SIDLIQIMDK WQRKWDESKI FETKHDNREK FFISAAFPYL    50
NGVLHAGHLR TFTIPETIAR YQRMKNKNVL WTFGFHVTGT PILGLANQIK 100
EKKEDIIWAY TNLHNIPMDE LLKLDTPEAI VECFSKKATD AFKKMGFSLD 150
WRRNFKTDDK VFSKFIEWQF YKLKDLGLIK KGSHPVRYCP KCENPVEDHD 200
LLHGEESTTV EYNLIKFTST FDEKDVIIPM ATLRPETVFG VTNAWVNPDE 250
IYVLAEVYDE IQKLDSEDVD LKYNGLWIVG KECADKLKEQ DKNIKILKEF 300
KGSELIGLKI KNPVTNLKVP IFPAEFVEMN IGTGCVMSVP AHAPYDYVAL 350
RDLEKVEEVG LISLIEIEGY GKYPAKEIVE KMNIKNQKDE ALLEEATSKI 400
YKDEFHKGKL NENCPEYKGT SVKDIKEKLI KDYMNFGISE IMYEFSEPKV 450
VCRCGEKCII KTVKGQWFIT YSDENWKRLA HECIDSMEFA PENLRHEFHN 500
KIDWMKDKAC ARRKGLGTKL PFDTNWMIES LSDSTIYMAY YTIARFINAG 550
INENQLTSEL FEYVFSGNGN LAEISNVSEV SIEIIEEMRK EFLYFYPLDW 600
RCSAKDLIPN HLSFMIFNHV ALFKKEHWPR GIEINGYVTI EGKKLSKSKG 650
PVLPVLEVSE TFGADVARFY ITTCAELPQD ADVKFKEMEK ARDNLIKLYE 700
LAVLVTKEGI IEKELSIIDK WLLHKTHSSI NFAEKAYEEF HLRKIGLMFY 750
ELINDLRWYK RRGGDNNGVL KEVVEIWTKL LSPVTPHLCE EIWELLGHNG 800
FISKEIFPNV KIEYINEELE LGEEFIRFTM EDIRNIKNVA KINPEKMYLY 850
TADDWKYELL EFMNKNSEKN VKELIPIVMK EERFKRHGKD VMKLINDLMK 900
VGVKKAIAEV EILENAKTFI EKEFECNVII GGEDFNGKKK FAIPYKPAIY 950
ME 952
Length:952
Mass (Da):111,051
Last modified:August 21, 2007 - v1
Checksum:i13D20D32E0B8A923
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR55467.1.
RefSeqiYP_001324079.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR55467; ABR55467; Mevan_1575.
GeneIDi5325458.
KEGGimvn:Mevan_1575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR55467.1 .
RefSeqi YP_001324079.1. NC_009634.1.

3D structure databases

ProteinModelPortali A6USJ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 406327.Mevan_1575.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR55467 ; ABR55467 ; Mevan_1575 .
GeneIDi 5325458.
KEGGi mvn:Mevan_1575.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci MVAN406327:GI04-1624-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB / ATCC 35089 / DSM 1224.

Entry informationi

Entry nameiSYL_METVS
AccessioniPrimary (citable) accession number: A6USJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi