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A6USJ5

- SYL_METVS

UniProt

A6USJ5 - SYL_METVS

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei647 – 6471ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN406327:GI04-1624-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mevan_1575
OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001107: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Leucine--tRNA ligasePRO_0000334846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi406327.Mevan_1575.

Structurei

3D structure databases

ProteinModelPortaliA6USJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi644 – 6485"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6USJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVENMETSFK SIDLIQIMDK WQRKWDESKI FETKHDNREK FFISAAFPYL
60 70 80 90 100
NGVLHAGHLR TFTIPETIAR YQRMKNKNVL WTFGFHVTGT PILGLANQIK
110 120 130 140 150
EKKEDIIWAY TNLHNIPMDE LLKLDTPEAI VECFSKKATD AFKKMGFSLD
160 170 180 190 200
WRRNFKTDDK VFSKFIEWQF YKLKDLGLIK KGSHPVRYCP KCENPVEDHD
210 220 230 240 250
LLHGEESTTV EYNLIKFTST FDEKDVIIPM ATLRPETVFG VTNAWVNPDE
260 270 280 290 300
IYVLAEVYDE IQKLDSEDVD LKYNGLWIVG KECADKLKEQ DKNIKILKEF
310 320 330 340 350
KGSELIGLKI KNPVTNLKVP IFPAEFVEMN IGTGCVMSVP AHAPYDYVAL
360 370 380 390 400
RDLEKVEEVG LISLIEIEGY GKYPAKEIVE KMNIKNQKDE ALLEEATSKI
410 420 430 440 450
YKDEFHKGKL NENCPEYKGT SVKDIKEKLI KDYMNFGISE IMYEFSEPKV
460 470 480 490 500
VCRCGEKCII KTVKGQWFIT YSDENWKRLA HECIDSMEFA PENLRHEFHN
510 520 530 540 550
KIDWMKDKAC ARRKGLGTKL PFDTNWMIES LSDSTIYMAY YTIARFINAG
560 570 580 590 600
INENQLTSEL FEYVFSGNGN LAEISNVSEV SIEIIEEMRK EFLYFYPLDW
610 620 630 640 650
RCSAKDLIPN HLSFMIFNHV ALFKKEHWPR GIEINGYVTI EGKKLSKSKG
660 670 680 690 700
PVLPVLEVSE TFGADVARFY ITTCAELPQD ADVKFKEMEK ARDNLIKLYE
710 720 730 740 750
LAVLVTKEGI IEKELSIIDK WLLHKTHSSI NFAEKAYEEF HLRKIGLMFY
760 770 780 790 800
ELINDLRWYK RRGGDNNGVL KEVVEIWTKL LSPVTPHLCE EIWELLGHNG
810 820 830 840 850
FISKEIFPNV KIEYINEELE LGEEFIRFTM EDIRNIKNVA KINPEKMYLY
860 870 880 890 900
TADDWKYELL EFMNKNSEKN VKELIPIVMK EERFKRHGKD VMKLINDLMK
910 920 930 940 950
VGVKKAIAEV EILENAKTFI EKEFECNVII GGEDFNGKKK FAIPYKPAIY

ME
Length:952
Mass (Da):111,051
Last modified:August 21, 2007 - v1
Checksum:i13D20D32E0B8A923
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA. Translation: ABR55467.1.
RefSeqiYP_001324079.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR55467; ABR55467; Mevan_1575.
GeneIDi5325458.
KEGGimvn:Mevan_1575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA. Translation: ABR55467.1 .
RefSeqi YP_001324079.1. NC_009634.1.

3D structure databases

ProteinModelPortali A6USJ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 406327.Mevan_1575.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR55467 ; ABR55467 ; Mevan_1575 .
GeneIDi 5325458.
KEGGi mvn:Mevan_1575.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci MVAN406327:GI04-1624-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB / ATCC 35089 / DSM 1224.

Entry informationi

Entry nameiSYL_METVS
AccessioniPrimary (citable) accession number: A6USJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3