Reviewed, UniProtKB/Swiss-Prot A6USF2 (APT2_METVS)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase 2
      Short name=APRT 2
    EC=2.4.2.7

Gene names

Name:	apt2
Ordered Locus Names:	Mevan_1531

Organism

Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]

Taxonomic identifier

406327 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Adenine phosphoribosyltransferase 2 HAMAP MF_00004		PRO_0000329378

Sequences

	Sequence		Length	Mass (Da)
	A6USF2-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: D6CE8FA5A5BE639D	FASTA	173	19,222
	10 20 30 40 50 60 MDLRKKIRII DDFPKKGISF KDVTPILKDP KSMKHTTKEI TKYLEDKNID VIVGPEARGF 70 80 90 100 110 120 LFGILVAQEL DLGFVPVRKP GKLPFKTFSV DYALEYGLDR LEIHSDSIEK GQNVAVVDDL 130 140 150 160 170 LATGGTVLGV TKLVEKIGGN VSALSFVIEL TNLNGRDKLK GYNVQSLVKY DDL

References

[1]

"Complete sequence of Methanococcus vannielii SB." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000742 Genomic DNA. Translation: ABR55424.1.
RefSeq	YP_001324036.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6USF2.
Genome annotation databases
GeneID	5325091.
GenomeReviews	Gene locus Mevan_1531 in contig CP000742_GR.
KEGG	mvn:Mevan_1531.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TIRYGSI.
Family and domain databases
HAMAP	MF_00004. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT2_METVS

Accession

Primary (citable) accession number: A6USF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)