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Protein

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase

Gene

aroA'

Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.UniRule annotation

Catalytic activityi

L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + 2,3-dioxopropylaldehyde phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptorUniRule annotation
Active sitei153 – 1531Proton donorUniRule annotation
Active sitei184 – 1841Schiff-base intermediate with substrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciMVAN406327:GI04-1555-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthaseUniRule annotation (EC:2.2.1.10UniRule annotation)
Short name:
ADH synthaseUniRule annotation
Short name:
ADHSUniRule annotation
Short name:
ADTH synthaseUniRule annotation
Gene namesi
Name:aroA'UniRule annotation
Ordered Locus Names:Mevan_1506
OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2722722-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthasePRO_0000363666Add
BLAST

Interactioni

Subunit structurei

Homodecamer.UniRule annotation

Protein-protein interaction databases

STRINGi406327.Mevan_1506.

Structurei

3D structure databases

ProteinModelPortaliA6USC8.
SMRiA6USC8. Positions 1-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 375DKFP bindingUniRule annotation
Regioni153 – 1553DKFP bindingUniRule annotation
Regioni209 – 2102DKFP bindingUniRule annotation
Regioni237 – 2382DKFP bindingUniRule annotation

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04044. Archaea.
COG1830. LUCA.
HOGENOMiHOG000224790.
KOiK16306.
OMAiIVRHGHR.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00960. ADH_synthase.
InterProiIPR010210. ADH_synthase.
IPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01949. AroFGH_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A6USC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMFDNIKNV GKLIRLERIF DKKSEKTVII PMDHGVSSGP LEGIKDMRIA
60 70 80 90 100
TNAVADGGAN AVLGHKGLVR HGHRGYGRDI GLIVHMSAGT SISPDPNKKV
110 120 130 140 150
IVTTVEDALR MGADAVSLHV NVGAETDFEM YRDLGLISET CEYWGMPLIA
160 170 180 190 200
MMYPRGPKIK DERDPEVVAH AARLGAELGA DIIKTNYTGD IDSFKDVVKG
210 220 230 240 250
CPAPIVIAGG PKTNTDEEFL QMVKDAMHAG SAGVASGRNV FQHKDVRGIT
260 270
SAICKIVHED VEVKEALNEI KI
Length:272
Mass (Da):29,411
Last modified:August 21, 2007 - v1
Checksum:i11730AE95F916CAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA. Translation: ABR55400.1.
RefSeqiWP_012066314.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR55400; ABR55400; Mevan_1506.
GeneIDi5324658.
KEGGimvn:Mevan_1506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA. Translation: ABR55400.1.
RefSeqiWP_012066314.1. NC_009634.1.

3D structure databases

ProteinModelPortaliA6USC8.
SMRiA6USC8. Positions 1-271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi406327.Mevan_1506.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR55400; ABR55400; Mevan_1506.
GeneIDi5324658.
KEGGimvn:Mevan_1506.

Phylogenomic databases

eggNOGiarCOG04044. Archaea.
COG1830. LUCA.
HOGENOMiHOG000224790.
KOiK16306.
OMAiIVRHGHR.

Enzyme and pathway databases

BioCyciMVAN406327:GI04-1555-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00960. ADH_synthase.
InterProiIPR010210. ADH_synthase.
IPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01949. AroFGH_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB / ATCC 35089 / DSM 1224.

Entry informationi

Entry nameiADHS_METVS
AccessioniPrimary (citable) accession number: A6USC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 21, 2007
Last modified: May 11, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.