Reviewed, UniProtKB/Swiss-Prot A6URY5 (MTD_METVS)

Names and origin

Protein names

Recommended name:
    F420-dependent methylenetetrahydromethanopterin dehydrogenase
      Short name=MTD
    EC=1.5.99.9
Alternative name(s):
    Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase

Gene names

Name:	mtd
Ordered Locus Names:	Mevan_1360

Organism

Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]

Taxonomic identifier

406327 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT By similarity.
Catalytic activity	5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420.
Pathway	One-carbon metabolism; methanogenesis from carbone dioxide; 5,10-methylene-H(4)MPT from 5,10-methenyl-H(4)MPT (cofactor F420 route): step 1/1.
Sequence similarities	Belongs to the MTD family.

Ontologies

Keywords
Biological process	Methanogenesis One-carbon metabolism
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro methylenetetrahydromethanopterin dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	F420-dependent methylenetetrahydromethanopterin dehydrogenase		PRO_1000007674

Sequences

	Sequence		Length	Mass (Da)
	A6URY5-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 1FBC53A1046AD27E	FASTA	276	29,964
	10 20 30 40 50 60 MVVKIGILKC GNIGMSPIID LCLDERADRN DIDVRVLGSG AKMNPDQVEE VSKKMVEEKP 70 80 90 100 110 120 DFIVYIGPNP AAPGPKKARE ILAASGIPSV IIGDAPGIKD KDAMAEQGLG YVLIKCDPMI 130 140 150 160 170 180 GARRQFLDPV EMAMFNADVI RVLAGTGALR VVQNAIDEMV FAVEEGKEIS LPKIVITEQK 190 200 210 220 230 240 AVDAMDFANP YAKAKAMAAF VMAEKTADID VKGCFMTKEM EKYIPIVASA HETIRYAAKM 250 260 270 VDEARELEKA TDAVSRKPHA GDGKILNKCK LMEKPE

References

[1]

"Complete sequence of Methanococcus vannielii SB." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000742 Genomic DNA. Translation: ABR55257.1.
RefSeq	YP_001323869.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5324853.
GenomeReviews	Gene locus Mevan_1360 in contig CP000742_GR.
KEGG	mvn:Mevan_1360.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00058. [Tree]
InterPro	IPR002844. Methylene_DHase. [Graphical view]
Pfam	PF01993. MTD. 1 hit. [Graphical view]
PIRSF	PIRSF005627. MTD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MTD_METVS

Accession

Primary (citable) accession number: A6URY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	November 25, 2008
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)